Prototypical Stressors

Showing 376 to 400 of 853 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

373	Glibenclamide		None
506	glucocorticoids		309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction
837	Gluten		524: Gluten-driven immune activation leading to celiac disease in genetically predisposed individuals
578	Glycyrrhizin	Glycyrrhizin, CAS-RN: 1405-86-3, DTXSID8047006	348: Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory
724	Gold	Gold, CAS-RN: 7440-57-5, DTXSID3064697	None
712	Gold nanoparticles		None
482	GOLPH3		None
530	Gossypol	Gossypol, CAS-RN: 303-45-7, DTXSID5023110	154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
255	Graphene oxide nanoparticles		2 AOPs 210: Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building 237: Substance interaction with lung resident cell membrane components leading to atherosclerosis
151	GW6471		6: Antagonist binding to PPARα leading to body-weight loss
239	Halofenozide	Halofenozide, CAS-RN: 112226-61-6, DTXSID4032619	2 AOPs 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade
788	Halogenated Hydrocarbons		519: Cardiac ion channels blockade leading to increased incidence of cardiovascular morbidity and mortality
160	Halogenated phenols		152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
178	Haloperidol	Haloperidol, CAS-RN: 52-86-8, DTXSID4034150	2 AOPs 170: Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat 555: Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure
351	Halothane	Halothane, CAS-RN: 151-67-7, DTXSID4025371	260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
620	HCoV-NL63		2 AOPs 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality 430: Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation
675	Heavy metals (cadmium, lead, copper, iron, nickel)		7 AOPs 499: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis 521: Essential element imbalance leads to reproductive failure via oxidative stress 324: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and cell death 325: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and reduced cell growth 326: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and reduced cell proliferation 539: Decreased Sodium/Potassium ATPase activity leads to Heart failure
276	Helicobacter pylori		217: Gastric ulcer formation
299	Helicobacter pylori infection		229: Helicobacter pylori to gastric ulcer
344	Heptachlor	Heptachlor, CAS-RN: 76-44-8, DTXSID3020679	10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
150	Hexachlorobenzene	Hexachlorobenzene, CAS-RN: 118-74-1, DTXSID2020682	131: Aryl hydrocarbon receptor activation leading to uroporphyria
500	High aspect ratio material		2 AOPs 303: Frustrated phagocytosis-induced lung cancer 409: Frustrated phagocytosis leads to malignant mesothelioma
646	high fat diet		403: combined unhealthy lifestyle factors leading to metabolic syndrome
503	High LET Ra		None
504	High LET Radiation		None