Prototypical Stressors

Showing 626 to 650 of 853 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

769	Polyethylene AS low Mol.Wt.	Polyethylene AS low Mol.Wt., CAS-RN: 9002-88-4, DTXSID8031946	505: Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway
331	Polymyxin B	Polymyxin B, CAS-RN: 1404-26-8, DTXSID1048467	257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
369	Polyoxin B	Polyoxin B, CAS-RN: 19396-06-6, DTXSID3058329	360: Chitin synthase 1 inhibition leading to mortality
593	Polyoxin D		360: Chitin synthase 1 inhibition leading to mortality
770	Polyvinyl chloride	Polyvinyl chloride, CAS-RN: 9002-86-2, DTXSID5025940	505: Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway
242	Ponasterone A	Ponasterone A, CAS-RN: 13408-56-5, DTXSID0040595	2 AOPs 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade
522	Porcupine		298: Increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer
455	Potassium bromate	Potassium bromate, CAS-RN: 7758-01-2, DTXSID6020195	296: Oxidative DNA damage leading to chromosomal aberrations and mutations
772	PPAR agonist		529: Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis
300	PPARalpha antagonists		2 AOPs 6: Antagonist binding to PPARα leading to body-weight loss 529: Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis
611	Pralnacasan (VX-740, HMR3480)		277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
608	Pralnacasan (VX-740)		None
487	Pralnacasan (VX-740) and Belnacasan (VX-765)		None
764	Preferred: Altered Gravity		None
702	Probucol	Probucol, CAS-RN: 23288-49-5, DTXSID2045440	None
705	Procainamide	Procainamide, CAS-RN: 51-06-9, DTXSID7023512	None
47	Prochloraz	Prochloraz, CAS-RN: 67747-09-5, DTXSID4024270	346: Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation
565	Procymidone	Procymidone, CAS-RN: 32809-16-8, DTXSID9033923	2 AOPs 344: Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring 477: Androgen receptor (AR) antagonism leading to hypospadias in male (mammalian) offspring
505	Progesterone,estrogen,melatonin,Letrozole		309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction
287	Propiconazole	Propiconazole, CAS-RN: 60207-90-1, DTXSID8024280	None
155	Propyl Acetate	Propyl acetate, CAS-RN: 109-60-4, DTXSID6021901	None
139	Propylene oxide		None
582	Propylpyrazoletriol		None
48	Propylthiouracil	6-Propyl-2-thiouracil, CAS-RN: 51-52-5, DTXSID5021209	5 AOPs 175: Thyroperoxidase inhibition leading to altered amphibian metamorphosis 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 271: Inhibition of thyroid peroxidase leading to impaired fertility in fish 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure
681	Prototypical stressor		211: Handbook development AOP