AOPs

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Showing 401 to 425 of 574 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
461 Deposition of ionising energy leads to population decline via impaired oogenesis and spermatogenesis Knut Erik Tollefsen BY-SA None None
462 Activation of reactive oxygen species leading the atherosclerosis Hiromi Ohara BY-SA 1115: Increase, Reactive oxygen species None
463 The AOP framwork on silica nanopariticles induced hepatoxicity Tianyu Li BY-SA None None
464 Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits Julia Meerman All rights reserved 896: Parkinsonian motor deficits
465 Alcohol dehydrogenase leading to reproductive dysfunction Donggon Yoo BY-SA 2045: Increase, Alcohol dehydrogenase None
466 Doda decarboxylase leading to mortality Donggon Yoo BY-SA 2051: Decrease, Tyrosine None
467 Knickkopf leading to mortality Donggon Yoo BY-SA 2058: Decrease, 20-hydroxyecdysone None
468 Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death) Laure-Alix Clerbaux BY-SA 1739: Binding to ACE2 1868: Hyperinflammation
469 Reactive oxygen speicies overproduction leading to increased digestive morbidity and mortality in generation population Ruiyang Ding BY-SA None None
470 Deposition of energy leads to abnormal vascular remodeling Vinita Chauhan BY-SA 1686: Deposition of Energy 2069: Occurrence, Abnormal Vascular Remodeling WPHA/WNT Endorsed 1.89
471 Neuron defect induced early behavioral change Woo-Keun Kim BY-SA 2195: Increase, CNS Neural cell death
472 DNA adduct formation leading to kidney failure Manoe Janssen BY-SA None None
473 Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin Danielle Beaton BY-SA 1686: Deposition of Energy
474 Succinate dehydrogenase inactivation leads to cancer by promoting EMT Sylvie Bortoli BY-SA 2118: Succinate dehydrogenase, inhibited 885: Increase, Cancer Under Development 1.106
475 Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons Shihori Tanabe All rights reserved 875: Binding of agonist, Ionotropic glutamate receptors 341: Impairment, Learning and memory Under Development 1.107
476 Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity Yue Zhang All rights reserved
477 Androgen receptor (AR) antagonism leading to hypospadias in male (mammalian) offspring Terje Svingen BY-SA 26: Antagonism, Androgen receptor 2082: Hypospadias, increased
478 Deposition of energy leading to occurrence of cataracts Vinita Chauhan BY-SA 1686: Deposition of Energy 2083: Occurrence of Cataracts WPHA/WNT Endorsed 1.89
479 Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress Sivakumar Murugadoss BY-SA 105: Inhibition, Mitochondrial Electron Transport Chain Complexes 2215: Decrease Left Ventricular function Under Development 1.102
480 Mitochondrial complexes inhibition leading to heart failure via decreased ATP production Alexandra Schaffert BY-SA 105: Inhibition, Mitochondrial Electron Transport Chain Complexes 2215: Decrease Left Ventricular function Under Development 1.102
481 AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases. Hailin Xu BY-SA 1115: Increase, Reactive oxygen species
482 Deposition of energy leading to occurrence of bone loss Vinita Chauhan BY-SA 1686: Deposition of Energy 2091: Occurrence, Bone Loss WPHA/WNT Endorsed 1.89
483 Deposition of Energy Leading to Learning and Memory Impairment Vinita Chauhan BY-SA 1686: Deposition of Energy 341: Impairment, Learning and memory WPHA/WNT Endorsed 1.89
484 Bisphenol A analogs induce cellular dysfunction in human trophoblast cells in a thyroid hormone receptor-dependent manner: in silico and in vitro analyses Xiaoyun Wu BY-SA None None
485 Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition Eliska Kuchovska BY-SA 1656: Antagonism, Thyroid Receptor 402: Cognitive function, decreased