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All Key Events

Showing 1076 to 1100 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1532	Decrease, Cardiac contractility Short Name Decrease, Cardiac contractility	0	Organ	Jun 19, 2018	Jun 19, 2018	6 AOPs 261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility 479: Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress 480: Mitochondrial complexes inhibition leading to heart failure via decreased ATP production 553: Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure 556: Decreased Na/K ATPase activity leading to heart failure 558: Phosphodiesterase inhibition leading to heart failure
1533	Decrease, Cardiac ejection fraction Short Name Decrease, Cardiac ejection fraction	0	Organ	Jun 19, 2018	Jun 19, 2018	261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
1534	Decrease, Blood pressure Short Name Decrease, Blood pressure	0	Individual	Jun 19, 2018	Jun 19, 2018	None
1535	Heart failure Short Name Heart failure	1	Organ	Jun 19, 2018	Dec 3, 2024	11 AOPs 261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 426: SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction. 427: ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure. 539: Decreased Sodium/Potassium ATPase activity leads to Heart failure 550: Increased LMNA gene mutation leading to heart failure 553: Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure 555: Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure 556: Decreased Na/K ATPase activity leading to heart failure 558: Phosphodiesterase inhibition leading to heart failure 552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP)
1536	Disruption, Intracellular calcium mobilization Short Name	0	Cellular	Jun 21, 2018	Jun 21, 2018	261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
1537	Disruption, Sarcomere assembly Short Name Disruption, Sarcomere assembly	0	Cellular	Jun 21, 2018	Jun 21, 2018	261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
1538	Decreased protection against oxidative stress Short Name	0	Cellular	Sep 13, 2018	Jul 15, 2022	2 AOPs 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 284: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease
1539	Endocytotic lysosomal uptake Short Name Endocytosis	1	Molecular	Nov 6, 2018	Aug 29, 2024	2 AOPs 144: Endocytic lysosomal uptake leading to liver fibrosis 530: Endocytotic lysosomal uptake leads to intestinal barrier disruption
1540	lysosomal disruption EMPTY Short Name lysosomal EMPTY	0	Molecular	Nov 12, 2018	Apr 17, 2024	None
1541	Mitochondrial Complex I inhibition Short Name Mitochondrial Complex I inhibition	0	Molecular	Dec 19, 2018	Dec 19, 2018	564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.
1542	Inhibition, Mitochondrial complex III Short Name Inhibition, Mitochondrial complex III	1	Molecular	Dec 19, 2018	Oct 3, 2025	4 AOPs 273: Mitochondrial complex inhibition leading to liver injury 286: Mitochondrial complex III antagonism leading to growth inhibition (1) 287: Mitochondrial complex III antagonism leading to growth inhibition (2) 587: Inhibition of the mitochondrial complex III of nigro-striatal neurons leads to parkinsonian motor deficits
1543	Mitochondrial Complex IV inhibition Short Name Mitochondrial Complex IV inhibition	0	Molecular	Dec 19, 2018	Mar 7, 2019	2 AOPs 273: Mitochondrial complex inhibition leading to liver injury 589: Inhibition of the mitochondrial complex IV of nigro-striatal neurons leads to parkinsonian motor deficits
1544	Mitochondrial Complex V inhibition Short Name Mitochondrial Complex V inhibition	0	Molecular	Dec 19, 2018	Mar 7, 2019	273: Mitochondrial complex inhibition leading to liver injury
1545	Decreased, mitochondrial oxidative phosphorylation Short Name	0	Cellular	Dec 19, 2018	Feb 4, 2026	2 AOPs 273: Mitochondrial complex inhibition leading to liver injury 567: Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition
1547	Mitochondrial Injury Short Name Mitochondrial Injury	0	Cellular	Dec 19, 2018	Dec 19, 2018	2 AOPs 273: Mitochondrial complex inhibition leading to liver injury 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
1548	Necrotic Tissue Short Name Necrotic Tissue	0	Tissue	Dec 19, 2018	Mar 7, 2019	2 AOPs 273: Mitochondrial complex inhibition leading to liver injury 278: IKK complex inhibition leading to liver injury
1549	Liver Injury Short Name Liver Injury	0	Organ	Dec 19, 2018	Mar 7, 2019	3 AOPs 273: Mitochondrial complex inhibition leading to liver injury 278: IKK complex inhibition leading to liver injury 285: Inhibition of N-linked glycosylation leads to liver injury
1550	Deposition of Ionizing Energy Short Name Ionizing Energy	0	Molecular	Dec 19, 2018	Dec 13, 2021	396: Deposition of ionizing energy leads to population decline via impaired meiosis
1552	Inadequate DNA repair (deprecated, please use https://aopwiki.org/events/155) Short Name DNA repair	0	Molecular	Dec 19, 2018	Jan 25, 2019	None
1553	Increase mutations Short Name Increase mutations	0	Molecular	Dec 19, 2018	Dec 19, 2018	534: Succinate dehydrogenase (SDH) inhibition leads to cancer through oxidative stress
1554	Increase Chromosomal Aberrations Short Name Increase chromosomal aberrations	0	Molecular	Dec 19, 2018	Aug 27, 2023	443: DNA damage and mutations leading to Metastatic Breast Cancer
1555	Increase cell proliferation Short Name Increase cell proliferation	0	Cellular	Dec 19, 2018	Dec 19, 2018	393: AOP for thyroid disorder caused by triphenyl phosphate via TRβ activation
1556	Increase, lung cancer Short Name Increase, lung cancer	0	Organ	Dec 19, 2018	Jan 10, 2023	272: Deposition of energy leading to lung cancer
1557	Neural crest cell migration, reduced Short Name Reduced neural crest cell migration	0	Cellular	Dec 20, 2018	Dec 20, 2018	2 AOPs 274: Histone deacetylase inhibition leads to impeded craniofacial development 436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
1558	Collagen production, reduced Short Name Reduced collagen production	0	Tissue	Dec 20, 2018	Dec 20, 2018	274: Histone deacetylase inhibition leads to impeded craniofacial development