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All Key Events

Showing 1526 to 1550 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

773	Increase, Endometrial adenocarcinomas Short Name Increase, Endometrial adenocarcinomas	2	Tissue	Nov 29, 2016	Sep 16, 2017	112: Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat)
772	Increase, Hyperplasia (glandular epithelial cells of endometrium) Short Name	2	Cellular	Nov 29, 2016	Sep 18, 2025	3 AOPs 112: Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat) 503: Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation 167: Early-life estrogen receptor agonism leading to endometrial adenosquamous carcinoma via promotion of sine oculis homeobox 1 progenitor cells
771	Decrease, Serum thyroid hormone (T4/T3) Short Name Decrease, Serum thyroid hormone (T4/T3)	1	Tissue	Nov 29, 2016	Sep 16, 2017	402: Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain
770	Increase, Cytotoxicity (club cells) Short Name Increase, Cytotoxicity (club cells)	1	Cellular	Nov 29, 2016	Sep 16, 2017	109: Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)
769	Increase, Oxidative metabolism Short Name Increase, Oxidative metabolism	1	Cellular	Nov 29, 2016	Dec 3, 2016	108: Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat)
768	Increase, Cytotoxicity Short Name Increase, Cytotoxicity	2	Cellular	Nov 29, 2016	Sep 16, 2017	3 AOPs 108: Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat) 136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors 284: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease
767	Increase, Hyperplasia (renal tubular cells) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	105: Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
766	Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme Short Name	1	Molecular	Nov 29, 2016	Dec 3, 2016	114: HPPD inhibition leading to corneal papillomas and carcinomas (in rat)
765	Decreased, population 1 Short Name Decreased, population 1	1	Population	Nov 29, 2016	Dec 3, 2016	113: Glutamate-gated chloride channel activation leading to acute mortality
764	N/A, Ataxia, paralysis, or hyperactivity Short Name	3	Organ	Nov 29, 2016	Sep 16, 2017	113: Glutamate-gated chloride channel activation leading to acute mortality
763	hyperpolarisation, neuron Short Name hyperpolarisation, neuron	1	Cellular	Nov 29, 2016	Sep 16, 2017	3 AOPs 113: Glutamate-gated chloride channel activation leading to acute mortality 233: Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening 235: Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening
762	Activation, ionotropic GABA Receptor chloride channel Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	160: Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality
761	Increased, Chloride conductance Short Name Increased, Chloride conductance	1	Cellular	Nov 29, 2016	Sep 16, 2017	3 AOPs 113: Glutamate-gated chloride channel activation leading to acute mortality 160: Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality 161: Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality
760	Activation, Glutamate-gated chloride channel Short Name	1	Molecular	Nov 29, 2016	Dec 3, 2016	113: Glutamate-gated chloride channel activation leading to acute mortality
759	Increased, Kidney Failure Short Name Increased, Kidney Failure	1	Population	Nov 29, 2016	Jan 16, 2019	6 AOPs 33: Kidney toxicity induced by activation of 5HT2C 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 413: Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways 622: Calcineurin inhibitor induced nephrotoxicity leading to kidney failure 472: DNA adduct formation leading to kidney failure
758	Hippocampal Physiology, Altered Short Name Hippocampal Physiology, Altered	1	Tissue	Nov 29, 2016	Jul 24, 2024	9 AOPs 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 8: Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 134: Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity 300: Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 442: Binding to voltage gate sodium channels during development leads to cognitive impairment
757	Hippocampal anatomy, Altered Short Name Hippocampal anatomy, Altered	1	Tissue	Nov 29, 2016	Jul 24, 2024	6 AOPs 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 8: Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 134: Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity 300: Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 442: Binding to voltage gate sodium channels during development leads to cognitive impairment
756	Hippocampal gene expression, Altered Short Name Hippocampal gene expression, Altered	1	Tissue	Nov 29, 2016	Aug 11, 2018	7 AOPs 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 8: Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 134: Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity 300: Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
754	Increased, Luteinizing hormone (LH) Short Name Increased, Luteinizing hormone (LH)	1	Tissue	Nov 29, 2016	Sep 16, 2017	111: Decrease in androgen receptor activity leading to Leydig cell tumors (in rat)
753	Increase, Thyroid-stimulating hormone (TSH) Short Name	2	Tissue	Nov 29, 2016	Sep 16, 2017	None
752	Altered, Meiotic chromosome dynamics Short Name Altered, Meiotic chromosome dynamics	1	Cellular	Nov 29, 2016	May 27, 2019	3 AOPs 106: Chemical binding to tubulin in oocytes leading to aneuploid offspring 396: Deposition of ionizing energy leads to population decline via impaired meiosis 435: Deposition of ionising energy leads to population decline via pollen abnormal
749	Decreased, Progesterone from corpus luteum Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	112: Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat)
748	Increased, Estrogen receptor (ER) activity Short Name	1	Molecular	Nov 29, 2016	Dec 3, 2016	465: Alcohol dehydrogenase leading to reproductive dysfunction
747	Decreased, Prolactin Short Name Decreased, Prolactin	1	Tissue	Nov 29, 2016	Sep 16, 2017	112: Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat)
746	Increase, Dopaminergic activity Short Name Increase, Dopaminergic activity	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 112: Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat) 611: Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes