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All Key Events

Showing 1676 to 1700 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

559	Activation, Nicotinic acetylcholine receptor Short Name	1	Molecular	Nov 29, 2016	Jun 7, 2018	9 AOPs 77: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 79: Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure 88: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 80: Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure 178: Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure
543	Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis Short Name	2	Individual	Nov 29, 2016	Dec 3, 2016	74: Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis
541	Decreased testosterone by the fetal Leydig cells, Decreased COUP-TFII stem Leydig cells Short Name	2	Cellular	Nov 29, 2016	Dec 3, 2016	74: Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis
540	Decreased testosterone by the fetal Leydig cells, Dysgensis of fetal Leydig cells Short Name	2	Organ	Nov 29, 2016	Dec 3, 2016	74: Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis
536	Altered, Chromosome number (polyploid) zygote Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 73: Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity 126: Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
535	Abnormal, Sperm penetration (polyspermy) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 73: Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity 126: Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
534	Altered, Formation of cortical envelope Short Name Altered, Formation of cortical envelope	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 73: Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity 126: Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
533	Decreased, Cortical granule release/distribution upon fertilization Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 73: Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity 126: Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
532	Delayed, Ovulation Short Name Delayed, Ovulation	1	Individual	Nov 29, 2016	Dec 3, 2016	2 AOPs 73: Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity 126: Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
531	Decreased, LH Surge Short Name Decreased, LH Surge	2	Cellular	Nov 29, 2016	Jan 13, 2025	4 AOPs 73: Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity 126: Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation 512: Reduced availability of GnRH leading to uterine adenocarcinoma via increased estrogen availability at target organ level 566: Decreased, GnRH pulsatility/release leading to estradiol availability, increased via impaired ovulation
530	Decreased, GnRH pulsatility/release Short Name Decreased, GnRH pulsatility/release	1	Cellular	Nov 29, 2016	Jan 28, 2026	4 AOPs 73: Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity 126: Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation 566: Decreased, GnRH pulsatility/release leading to estradiol availability, increased via impaired ovulation 609: Activation, estrogen receptor alpha leads to prolonged estrus cycle via decreased kisspeptin release
529	Decreased, GnRH cfos activity Short Name Decreased, GnRH cfos activity	1	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 73: Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity 126: Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
528	Decreased, Synthesis of NE Short Name Decreased, Synthesis of NE	1	Cellular	Nov 29, 2016	Sep 16, 2017	73: Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity
527	Decreased, Decreased fecundity Short Name Decreased, Decreased fecundity	2	Individual	Nov 29, 2016	Dec 3, 2016	2 AOPs 73: Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity 126: Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
526	Inhibition, Inhibition of Dopamine-beta-hydroxylase Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	73: Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity
525	Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells Short Name	2	Cellular	Nov 29, 2016	Sep 16, 2017	71: Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation
520	Decreased sperm quantity or quality in the adult, Decreased fertility Short Name	4	Individual	Nov 29, 2016	Dec 3, 2016	5 AOPs 70: Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell 71: Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation 64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility 476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity 595: Emerging OPFRS reproductive outcome pathway
505	Decreased sperm quantity / quality in the adult, Decreased fertility Short Name	2	Individual	Nov 29, 2016	Dec 3, 2016	3 AOPs 66: Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis 67: Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis 68: Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome
496	Increased apoptosis, decreased fetal/adult Leydig Cells Short Name Decreased Leydig Cells	1	Cellular	Nov 29, 2016	May 17, 2023	2 AOPs 64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility 476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity
495	Repressed expression of steroidogenic enzymes Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility 595: Emerging OPFRS reproductive outcome pathway
494	Glucocorticoid Receptor Agonist, Activation Short Name GR Agonist, Activation	1	Molecular	Nov 29, 2016	Sep 16, 2017	64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility
493	Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	46: AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
491	Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF) Short Name	1	Organ	Nov 29, 2016	Sep 16, 2017	46: AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
488	Decrease, Ovulation Short Name Decrease, Ovulation	1	Organ	Nov 29, 2016	Sep 16, 2017	63: Cyclooxygenase inhibition leading to reproductive dysfunction
486	systemic inflammation leading to hepatic steatosis Short Name inflammation	1	Organ	Nov 29, 2016	Feb 24, 2017	62: AKT2 activation leading to hepatic steatosis