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All KERs

Showing 1426 to 1450 of 3164 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2609	185: Increase, Mutations	1980: Increase,miRNA levels	Mar 22, 2022	Aug 27, 2023	1 AOP 443: DNA damage and mutations leading to Metastatic Breast Cancer
1485	1373: Increase, mucous	1380: Activate, mucosal defense	Apr 17, 2017	Apr 17, 2017	1 AOP 217: Gastric ulcer formation
1486	1374: Increase, mucosal blood flow	1380: Activate, mucosal defense	Apr 17, 2017	Apr 17, 2017	1 AOP 217: Gastric ulcer formation
991	962: Increase, Mucin production	943: Hypersecretion, Mucus	Nov 29, 2016	Nov 29, 2016	None
1315	962: Increase, Mucin production	1251: Chronic, Mucus hypersecretion	Nov 29, 2016	Aug 30, 2021	None
2859	962: Increase, Mucin production	1250: Decreased lung function	Mar 15, 2023	Mar 16, 2023	1 AOP 148: EGFR Activation Leading to Decreased Lung Function
198	350: Increase, Mortality	328: Decrease, Fecundity	Nov 29, 2016	Dec 3, 2016	None
199	350: Increase, Mortality	361: Decline, Population	Nov 29, 2016	Dec 3, 2016	None
1004	350: Increase, Mortality	765: Decreased, population 1	Nov 29, 2016	Dec 3, 2016	None
1013	350: Increase, Mortality	997: Decreased, Population size	Nov 29, 2016	Dec 3, 2016	None
2463	350: Increase, Mortality	360: Decrease, Population growth rate	Aug 5, 2021	Aug 5, 2021	None
2797	2072: Increase, Mitochondrial swelling	55: Cell injury/death	Nov 1, 2022	Nov 1, 2022	1 AOP 268: Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling
363	177: Increase, Mitochondrial dysfunction	55: Cell injury/death	Nov 29, 2016	Nov 29, 2016	4 AOPs 144: Endocytic lysosomal uptake leading to liver fibrosis 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 530: Endocytotic lysosomal uptake leads to intestinal barrier disruption 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction
582	177: Increase, Mitochondrial dysfunction	386: Neuronal network function, Decreased	Nov 29, 2016	Dec 3, 2016	1 AOP 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1
660	177: Increase, Mitochondrial dysfunction	664: Overwhelmed, Mitochondrial DNA repair mechanisms	Nov 29, 2016	Dec 3, 2016	1 AOP 80: Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
664	177: Increase, Mitochondrial dysfunction	583: impaired, Thoracic shivering	Nov 29, 2016	Dec 3, 2016	None
904	177: Increase, Mitochondrial dysfunction	889: Proteostasis, impaired	Nov 29, 2016	Oct 3, 2025	2 AOPs 3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits 273: Mitochondrial complex inhibition leading to liver injury
908	177: Increase, Mitochondrial dysfunction	890: Degeneration of dopaminergic neurons of the nigrostriatal pathway	Nov 29, 2016	Oct 3, 2025	4 AOPs 3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits 587: Inhibition of the mitochondrial complex III of nigro-striatal neurons leads to parkinsonian motor deficits 588: Inhibition of the mitochondrial complex II of nigro-striatal neurons leads to parkinsonian motor deficits 589: Inhibition of the mitochondrial complex IV of nigro-striatal neurons leads to parkinsonian motor deficits
1152	177: Increase, Mitochondrial dysfunction	568: impaired, Hive thermoregulation	Nov 29, 2016	Dec 3, 2016	1 AOP 79: Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure
1154	177: Increase, Mitochondrial dysfunction	1107: Weakened, Colony	Nov 29, 2016	Dec 3, 2016	1 AOP 178: Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure
1311	177: Increase, Mitochondrial dysfunction	1243: Altered, Ca2+-calmodulin activated signal transduction	Nov 29, 2016	Dec 3, 2016	2 AOPs 77: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure
1684	177: Increase, Mitochondrial dysfunction	1392: Increase, Oxidative Stress	Nov 9, 2017	Nov 9, 2017	2 AOPs 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits 479: Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress
2228	177: Increase, Mitochondrial dysfunction	1771: Decrease, ATP pool	Dec 4, 2020	Dec 4, 2020	None
2822	177: Increase, Mitochondrial dysfunction	40: Mitochondrial ATP production, decreased	Jan 5, 2023	Jan 5, 2023	2 AOPs 480: Mitochondrial complexes inhibition leading to heart failure via decreased ATP production 258: Renal protein alkylation leading to kidney toxicity
3131	177: Increase, Mitochondrial dysfunction	1365: Increase, Apoptosis	Feb 21, 2024	Feb 21, 2024	2 AOPs 509: Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways

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