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Showing 1051 to 1075 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

659	663: Desensitization, Nicotinic acetylcholine receptor	386: Neuronal network function, Decreased	Nov 29, 2016	Dec 3, 2016	1 AOP 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2
1309	663: Desensitization, Nicotinic acetylcholine receptor	1243: Altered, Ca2+-calmodulin activated signal transduction	Nov 29, 2016	Dec 3, 2016	2 AOPs 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 88: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste
3381	2273: Dihydrotestosterone (DHT) levels, increased	2274: Androgen receptor activation, increased	Nov 2, 2024	Nov 24, 2024	None
973	944: dimerization, AHR/ARNT	945: reduced dimerization, ARNT/HIF1-alpha	Nov 29, 2016	Mar 23, 2018	2 AOPs 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF 151: AhR activation leading to preeclampsia
1350	944: dimerization, AHR/ARNT	1269: Increase, COX-2 expression	Feb 9, 2017	May 9, 2017	1 AOP 21: Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2
1996	944: dimerization, AHR/ARNT	1697: Increase, DNMT expression	Oct 30, 2019	Oct 30, 2019	1 AOP 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
2682	944: dimerization, AHR/ARNT	2020: Decrease, sox9 expression	Jun 30, 2022	Jun 30, 2022	None
2683	944: dimerization, AHR/ARNT	2021: Increase, slincR expression	Jun 30, 2022	Sep 8, 2022	2 AOPs 455: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
3466	944: dimerization, AHR/ARNT	2124: increased, Bax	Jan 4, 2025	May 27, 2025	1 AOP 563: Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis
3701	2396: Diminished differentiation of activated B lymphocytes	2398: Reduced antibody production	Dec 3, 2025	Dec 3, 2025	1 AOP 618: PPARgamma activation leads to a diminished vaccine response
3704	2395: Diminished proliferation of activated B lymphocytes	2396: Diminished differentiation of activated B lymphocytes	Dec 3, 2025	Dec 3, 2025	1 AOP 618: PPARgamma activation leads to a diminished vaccine response
2359	1869: Diminished Protective Response to ROS	1845: Coagulation	Apr 20, 2021	Jan 26, 2024	1 AOP 379: Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation
2413	1869: Diminished Protective Response to ROS	1895: inflammasome activity, increased	Jun 25, 2021	Jun 25, 2021	1 AOP 406: SARS-CoV-2 infection leading to hyperinflammation
3703	2394: Lower survival B lymphocytes	2395: Diminished proliferation of activated B lymphocytes	Dec 3, 2025	Dec 3, 2025	1 AOP 618: PPARgamma activation leads to a diminished vaccine response
2537	1958: Direct hERG channel blockage	1960: Inhibition of Ikr	Dec 13, 2021	Dec 13, 2021	None
3145	1260: Direct mitochondrial inhibition	177: Increase, Mitochondrial dysfunction	Mar 13, 2024	Mar 13, 2024	1 AOP 205: AOP from chemical insult to cell death
737	721: Disorganization, Meiotic Spindle	752: Altered, Meiotic chromosome dynamics	Nov 29, 2016	Dec 13, 2019	1 AOP 106: Chemical binding to tubulin in oocytes leading to aneuploid offspring
2249	1830: Displacement, Serum thyroxine (T4) from carrier protein	959: Increased, Free serum thyroxine (T4)	Dec 9, 2020	Dec 9, 2020	2 AOPs 366: Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis 367: Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis
2246	958: Displacement, Serum thyroxine (T4) from transthyretin	959: Increased, Free serum thyroxine (T4)	Dec 9, 2020	Dec 9, 2020	1 AOP 152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
3210	2225: Disrupted Lipid Storage	327: Accumulation, Fatty acid	May 8, 2024	May 28, 2024	1 AOP 529: Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis
3211	2225: Disrupted Lipid Storage	291: Accumulation, Triglyceride	May 8, 2024	May 29, 2024	1 AOP 529: Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis
3221	2227: Disrupted PPAR isoform nuclear signaling	2224: Dysregulation of transcriptional expression within PPAR signaling network	May 14, 2024	May 23, 2024	1 AOP 529: Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis
3222	2227: Disrupted PPAR isoform nuclear signaling	179: Decrease, Fatty acid β-oxidation	May 14, 2024	May 14, 2024	None
3599	2353: Disrupted, energy metabolism	2354: Activation, Apoptosis signaling	Aug 16, 2025	Aug 16, 2025	1 AOP 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis
2481	1882: Disrupted, meiotic initiation in oocyte	1883: Decreased, ovarian reserve	Sep 13, 2021	Dec 18, 2024	1 AOP 398: Decreased ALDH1A (RALDH) activity leading to decreased fertility via disrupted meiotic initiation of fetal oogonia

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