Key Event Relationships (KERs)

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Showing 2551 to 2575 of 3081 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
2715 1547: Mitochondrial Injury 1825: Increase, Cell death Jul 25, 2022 Jul 25, 2022 None
3049 1547: Mitochondrial Injury 1812: Increase, Cyt c release Sep 14, 2023 Sep 14, 2023
603 598: modulation, sodium channel 599: prolonged, Depolarization of neuronal membrane Nov 29, 2016 Dec 3, 2016
802 801: modulation, Unknown 802: Increased, HIF-1 alpha transcription Nov 29, 2016 Dec 3, 2016
2448 1912: Motile Cilia Number/Length, Decreased 1908: CBF, Decreased Jul 23, 2021 Sep 28, 2021
1563 1425: Mu Opioid Receptor Agonism 1426: Release of G Proteins Jun 8, 2017 Jun 8, 2017
2443 1909: MCC, Decreased 1250: Decreased lung function Jul 19, 2021 Mar 24, 2023
2445 1910: Mucus Viscosity, Increased 1908: CBF, Decreased Jul 19, 2021 Aug 2, 2021 None
2446 1910: Mucus Viscosity, Increased 1909: MCC, Decreased Jul 19, 2021 Aug 2, 2021 None
757 764: N/A, Ataxia, paralysis, or hyperactivity 351: Increased Mortality Nov 29, 2016 Dec 3, 2016
88 75: N/A, Covalent binding to protein, possibly lysine residue 151: Activation, Inflammatory cytokines, chemokines, cytoprotective gene pathways Nov 29, 2016 Sep 24, 2020 None
1700 75: N/A, Covalent binding to protein, possibly lysine residue 398: Activation, Dendritic Cells Dec 7, 2017 Sep 24, 2020 None
136 119: N/A, Gap 49: Reduction, Ca and HCO3 transport to shell gland Nov 29, 2016 Dec 3, 2016
996 139: N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects 854: Alterations, Cellular proliferation / hyperplasia Nov 29, 2016 Dec 2, 2016
593 590: N/A, hypoxia 591: Increased, amputations Nov 29, 2016 Dec 3, 2016
3307 590: N/A, hypoxia 1376: Increase, angiogenesis Jul 18, 2024 Jul 18, 2024 None
3370 590: N/A, hypoxia 885: Increase, Cancer Oct 25, 2024 Oct 25, 2024
168 158: N/A, Interferences with SH-/selen-proteins 130: Depletion, GSH Nov 29, 2016 Dec 3, 2016 None
2889 345: N/A, Liver Steatosis 55: Cell injury/death Apr 13, 2023 Apr 13, 2023 None
182 173: N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number 321: N/A, Cyanosis occurs Nov 29, 2016 Dec 3, 2016
207 352: N/A, Neurodegeneration 188: Neuroinflammation Nov 29, 2016 Jun 13, 2018
368 352: N/A, Neurodegeneration 386: Neuronal network function, Decreased Nov 29, 2016 Dec 3, 2016 None
647 352: N/A, Neurodegeneration 618: Decreased, Neuronal network function in adult brain Nov 29, 2016 Nov 29, 2016
1069 352: N/A, Neurodegeneration 341: Impairment, Learning and memory Nov 29, 2016 Apr 11, 2024
2287 352: N/A, Neurodegeneration 1841: Encephalitis Feb 23, 2021 Feb 23, 2021