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Showing 2901 to 2925 of 3119 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

94	78: Reduction, Cumulative fecundity and spawning	360: Decrease, Population growth rate	Nov 29, 2016	Mar 20, 2017	12 AOPs 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 30: Estrogen receptor antagonism leading to reproductive dysfunction 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 289: Inhibition of 5α-reductase leading to impaired fecundity in female fish 216: Deposition of energy leading to population decline via DNA strand breaks and follicular atresia 238: Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis
2142	78: Reduction, Cumulative fecundity and spawning	361: Decline, Population	May 25, 2020	May 25, 2020	None
2924	78: Reduction, Cumulative fecundity and spawning	442: Decreased, Population trajectory	May 22, 2023	May 22, 2023	2 AOPs 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish
3228	1610: Reduction, DHEA	1690: Decrease, circulating testosterone levels	May 24, 2024	Apr 8, 2025	1 AOP 288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)
123	106: Reduction, Eggshell thickness	253: N/A, Reproductive failure	Nov 29, 2016	Dec 3, 2016	1 AOP 28: Cyclooxygenase inhibition leading reproductive failure
460	446: Reduction of testosterone	414: Increase, Luteinizing hormone (LH)	Nov 29, 2016	Dec 3, 2016	None
608	446: Reduction of testosterone	348: Malformation, Male reproductive tract	Nov 29, 2016	Dec 2, 2016	None
1649	446: Reduction of testosterone	520: Decreased sperm quantity or quality in the adult, Decreased fertility	Aug 11, 2017	Aug 11, 2017	None
143	129: Reduction, Gonadotropins, circulating concentrations	274: Reduction, Testosterone synthesis by ovarian theca cells	Nov 29, 2016	Mar 20, 2017	1 AOP 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
667	64: Reduction, Ionotropic GABA receptor chloride channel conductance	669: Reduction, Neuronal synaptic inhibition	Nov 29, 2016	Apr 29, 2019	1 AOP 10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
683	669: Reduction, Neuronal synaptic inhibition	682: Generation, Amplified excitatory postsynaptic potential (EPSP)	Nov 29, 2016	May 15, 2018	1 AOP 10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
1018	981: Reduction, NFAT/AP-1 complex formation	982: Suppression, Suppression in mixed lymphocyte reaction (MLR)	Nov 29, 2016	Dec 3, 2016	None
1019	981: Reduction, NFAT/AP-1 complex formation	983: Suppression, Suppression of T-cell dependent antibody response (TDAR)	Nov 29, 2016	Dec 3, 2016	None
1020	981: Reduction, NFAT/AP-1 complex formation	984: Impairment, T-cell dependent antibody response	Nov 29, 2016	Dec 3, 2016	None
1021	981: Reduction, NFAT/AP-1 complex formation	985: Relief, Relief of atopic dermatitis	Nov 29, 2016	Dec 3, 2016	None
1022	981: Reduction, NFAT/AP-1 complex formation	986: Impairment of TDAR	Nov 29, 2016	Dec 3, 2016	None
1256	981: Reduction, NFAT/AP-1 complex formation	1203: Suppression, Suppression of production of cytotoxic T-cells	Nov 29, 2016	Dec 3, 2016	None
1257	981: Reduction, NFAT/AP-1 complex formation	1204: Suppression, Suppression of T-cell dependent antibody production	Nov 29, 2016	Dec 3, 2016	None
1509	981: Reduction, NFAT/AP-1 complex formation	1202: Suppression, IL-2 and IL-4 production	May 19, 2017	Jun 27, 2021	1 AOP 154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
252	219: Reduction, Plasma 17beta-estradiol concentrations	285: Reduction, Vitellogenin synthesis in liver	Nov 29, 2016	Mar 20, 2017	5 AOPs 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
253	219: Reduction, Plasma 17beta-estradiol concentrations	309: Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development	Nov 29, 2016	Nov 29, 2016	None
392	219: Reduction, Plasma 17beta-estradiol concentrations	405: disrupted, ovarian cycle	Nov 29, 2016	Dec 3, 2016	1 AOP 7: Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female
1386	219: Reduction, Plasma 17beta-estradiol concentrations	221: Reduction, Plasma vitellogenin concentrations	Mar 17, 2017	Oct 18, 2018	7 AOPs 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 25: Aromatase inhibition leading to reproductive dysfunction 271: Inhibition of thyroid peroxidase leading to impaired fertility in fish 289: Inhibition of 5α-reductase leading to impaired fecundity in female fish 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish
2922	219: Reduction, Plasma 17beta-estradiol concentrations	2139: Reduction, the ratio of E2/11-KT in plasma	May 22, 2023	May 22, 2023	1 AOP 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish）
255	221: Reduction, Plasma vitellogenin concentrations	309: Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development	Nov 29, 2016	Mar 20, 2017	9 AOPs 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 25: Aromatase inhibition leading to reproductive dysfunction 30: Estrogen receptor antagonism leading to reproductive dysfunction 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production 549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish

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