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Showing 701 to 725 of 3164 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3169	1690: Decrease, circulating testosterone levels	2212: Epididymal agenesis	Mar 20, 2024	Dec 3, 2024	1 AOP 526: Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Impaired, Spermatogenesis
3202	1690: Decrease, circulating testosterone levels	809: malformed, Male reproductive tract	Apr 25, 2024	Apr 25, 2024	1 AOP 124: HMG-CoA reductase inhibition leading to decreased fertility
3205	1690: Decrease, circulating testosterone levels	348: Malformation, Male reproductive tract	May 1, 2024	May 1, 2024	1 AOP 18: PPARα activation in utero leading to impaired fertility in males
3206	1690: Decrease, circulating testosterone levels	414: Increase, Luteinizing hormone (LH)	May 1, 2024	May 1, 2024	1 AOP 51: PPARα activation leading to impaired fertility in adult male rodents
3213	1690: Decrease, circulating testosterone levels	219: Reduction, Plasma 17beta-estradiol concentrations	May 8, 2024	May 8, 2024	1 AOP 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish）
3214	1690: Decrease, circulating testosterone levels	2139: Reduction, the ratio of E2/11-KT in plasma	May 8, 2024	May 8, 2024	1 AOP 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish）
3225	1690: Decrease, circulating testosterone levels	520: Decreased sperm quantity or quality in the adult, Decreased fertility	May 24, 2024	May 24, 2024	1 AOP 64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility
3227	1690: Decrease, circulating testosterone levels	791: Increased, Leutinizing hormone (LH)	May 24, 2024	May 24, 2024	1 AOP 120: Inhibition of 5α-reductase leading to Leydig cell tumors (in rat)
3349	1690: Decrease, circulating testosterone levels	1688: AGD, decreased	Oct 1, 2024	May 6, 2025	1 AOP 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring
3350	1690: Decrease, circulating testosterone levels	2082: Hypospadias	Oct 1, 2024	Apr 7, 2026	1 AOP 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring
3486	1690: Decrease, circulating testosterone levels	1786: nipple retention, increased	Jan 30, 2025	Mar 20, 2026	1 AOP 575: Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring
3620	1690: Decrease, circulating testosterone levels	1758: Impaired, Spermatogenesis	Sep 3, 2025	Sep 3, 2025	1 AOP 595: Emerging OPFRS reproductive outcome pathway
1600	1446: Decrease, Coupling of OXPHOS	40: Mitochondrial ATP production, decreased	Jun 29, 2017	Jun 29, 2017	None
2175	1446: Decrease, Coupling of OXPHOS	1808: Decrease, ATP synthase activity	Nov 2, 2020	Nov 2, 2020	None
2182	1446: Decrease, Coupling of OXPHOS	1811: Increase, Complex III dysfunction	Nov 2, 2020	Nov 2, 2020	None
2188	1446: Decrease, Coupling of OXPHOS	1813: Increase, Complex I dysfunction	Nov 2, 2020	Nov 2, 2020	None
2203	1446: Decrease, Coupling of OXPHOS	1771: Decrease, ATP pool	Nov 12, 2020	Jul 6, 2022	9 AOPs 263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation 264: Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death 266: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity 331: Reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 596: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death 612: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced adenosine triphosphate 326: Reactive oxygen species leading to growth inhibition via lipid peroxidation and decreased cell proliferation 332: Reactive oxygen species leading to growth inhibition via protein oxidation and decreased cell proliferation 333: Reactive oxygen species leading to growth inhibition via protein oxidation and cell death
2219	1446: Decrease, Coupling of OXPHOS	1826: Increase, Oxygen consumption	Dec 4, 2020	Dec 4, 2020	None
2763	1446: Decrease, Coupling of OXPHOS	2064: Increase, Cytosolic Ca	Sep 13, 2022	Sep 13, 2022	1 AOP 265: Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium
2793	1446: Decrease, Coupling of OXPHOS	2070: Increase, Glycolysis	Nov 1, 2022	Nov 1, 2022	1 AOP 267: Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion
2796	1446: Decrease, Coupling of OXPHOS	2072: Increase, Mitochondrial swelling	Nov 1, 2022	Nov 1, 2022	1 AOP 268: Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling
3495	1446: Decrease, Coupling of OXPHOS	1115: Increase, ROS	Feb 25, 2025	Feb 25, 2025	2 AOPs 534: Succinate dehydrogenase (SDH) inhibition leads to oxidative stress 613: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via increased reactive oxygen species production
1743	1523: Decrease, Cuticular chitin content	1524: Increase, Premature molting	May 24, 2018	Feb 17, 2021	3 AOPs 360: Chitin synthase 1 inhibition leading to mortality 361: Sulfonylureareceptor binding leading to mortality 606: Ecdysone receptor antagonism leading to mortality via inhibition of chitin synthase 1
1011	996: Decrease, Digestion of old cuticle	990: Increase, Incomplete ecdysis	Nov 29, 2016	Dec 3, 2016	None
2171	996: Decrease, Digestion of old cuticle	1524: Increase, Premature molting	Oct 21, 2020	Oct 21, 2020	2 AOPs 358: Chitinase inhibition leading to mortality 359: Chitobiase inhibition leading to mortality

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