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Showing 701 to 725 of 3119 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3349	1690: Decrease, circulating testosterone levels	1688: AGD, decreased	Oct 1, 2024	May 6, 2025	1 AOP 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring
3350	1690: Decrease, circulating testosterone levels	2082: Hypospadias	Oct 1, 2024	Apr 7, 2026	1 AOP 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring
3486	1690: Decrease, circulating testosterone levels	1786: nipple retention, increased	Jan 30, 2025	Mar 20, 2026	1 AOP 575: Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring
3620	1690: Decrease, circulating testosterone levels	1758: Impaired, Spermatogenesis	Sep 3, 2025	Sep 3, 2025	1 AOP 595: Emerging OPFRS reproductive outcome pathway
1600	1446: Decrease, Coupling of OXPHOS	40: Mitochondrial ATP production, decreased	Jun 29, 2017	Jun 29, 2017	None
2175	1446: Decrease, Coupling of OXPHOS	1808: Decrease, ATP synthase activity	Nov 2, 2020	Nov 2, 2020	None
2182	1446: Decrease, Coupling of OXPHOS	1811: Increase, Complex III dysfunction	Nov 2, 2020	Nov 2, 2020	None
2188	1446: Decrease, Coupling of OXPHOS	1813: Increase, Complex I dysfunction	Nov 2, 2020	Nov 2, 2020	None
2203	1446: Decrease, Coupling of OXPHOS	1771: Decrease, ATP pool	Nov 12, 2020	Jul 6, 2022	11 AOPs 263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation 264: Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death 266: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity 324: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and cell death 325: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and reduced cell growth 326: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and reduced cell proliferation 331: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 332: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and reduced cell growth 333: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and reduced cell proliferation 596: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death 612: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced adenosine triphosphate
2219	1446: Decrease, Coupling of OXPHOS	1826: Increase, Oxygen consumption	Dec 4, 2020	Dec 4, 2020	None
2763	1446: Decrease, Coupling of OXPHOS	2064: Increase, Cytosolic Ca	Sep 13, 2022	Sep 13, 2022	1 AOP 265: Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium
2793	1446: Decrease, Coupling of OXPHOS	2070: Increase, Glycolysis	Nov 1, 2022	Nov 1, 2022	1 AOP 267: Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion
2796	1446: Decrease, Coupling of OXPHOS	2072: Increase, Mitochondrial swelling	Nov 1, 2022	Nov 1, 2022	1 AOP 268: Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling
3495	1446: Decrease, Coupling of OXPHOS	1115: Increase, ROS	Feb 25, 2025	Feb 25, 2025	2 AOPs 534: Succinate dehydrogenase (SDH) inhibition leads to oxidative stress 613: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via increased reactive oxygen species production
1743	1523: Decrease, Cuticular chitin content	1524: Increase, Premature molting	May 24, 2018	Feb 17, 2021	3 AOPs 360: Chitin synthase 1 inhibition leading to mortality 361: Sulfonylureareceptor binding leading to mortality 606: Ecdysone receptor antagonism leading to mortality via inhibition of chitin synthase 1
1011	996: Decrease, Digestion of old cuticle	990: Increase, Incomplete ecdysis	Nov 29, 2016	Dec 3, 2016	None
2171	996: Decrease, Digestion of old cuticle	1524: Increase, Premature molting	Oct 21, 2020	Oct 21, 2020	2 AOPs 358: Chitinase inhibition leading to mortality 359: Chitobiase inhibition leading to mortality
1881	1613: Decrease, DHT level	219: Reduction, Plasma 17beta-estradiol concentrations	Apr 18, 2019	Apr 18, 2019	1 AOP 289: Inhibition of 5α-reductase leading to impaired fecundity in female fish
1935	1613: Decrease, DHT level	1614: Decrease, AR activation	Jun 3, 2019	Mar 20, 2026	4 AOPs 288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) 305: 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring 571: 5α-reductase inhibition leading to hypospadias in male (mammalian) offspring 576: 5α-reductase inhibition leading to increased nipple retention (NR) in male (rodent) offspring
3172	1613: Decrease, DHT level	2213: Impaired, urethral tube closure	Mar 20, 2024	Dec 3, 2024	1 AOP 527: Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Hypospadias, increased
2745	2052: Decrease, dopa decarboxylase	2053: Increase, Defects in tanning of new cuticle	Aug 28, 2022	Aug 28, 2022	1 AOP 466: Doda decarboxylase leading to mortality
1087	1056: Decrease, E2 blood concentrations at hypothalamus	1047: Increased, secretion of GnRH from hypothalamus	Nov 29, 2016	Dec 3, 2016	1 AOP 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
1348	1267: Decrease, Ecdysis motor program activity	1268: Decrease, Excitatory postsynaptic potential	Feb 9, 2017	Feb 9, 2017	None
3639	1267: Decrease, Ecdysis motor program activity	993: Decrease, Abdominal muscle contraction	Sep 29, 2025	Sep 29, 2025	3 AOPs 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade 343: Ecdysone receptor antagonism leading to mortality via mis-timed ecdysone receptor-responsive nuclear receptor cascade
3059	2196: Decrease, elavl3	352: N/A, Neurodegeneration	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Neuron defect induced early behavioral change

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