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Showing 1626 to 1650 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1599	1445: Increase, LPO	1446: Decrease, Coupling of OXPHOS	Jun 29, 2017	Jun 29, 2017	3 AOPs 331: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 332: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and reduced cell growth 333: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and reduced cell proliferation
2097	1445: Increase, LPO	1772: Decrease, TAG	Apr 30, 2020	Apr 30, 2020	1 AOP 329: Excessive reactive oxygen species production leading to mortality (3)
2210	1445: Increase, LPO	1365: Increase, Apoptosis	Nov 25, 2020	Nov 25, 2020	None
2222	1445: Increase, LPO	1825: Increase, Cell death	Dec 4, 2020	Dec 4, 2020	None
2464	1445: Increase, LPO	1607: Increase, Necrosis	Aug 11, 2021	Aug 11, 2021	1 AOP 413: Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure
2879	1445: Increase, LPO	406: decreased, Fertility	Apr 5, 2023	Sep 14, 2023	1 AOP 492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress
3117	1445: Increase, LPO	2206: Increased, histomorphological alteration of testis	Jan 24, 2024	Apr 11, 2024	1 AOP 521: Essential element imbalance leads to reproductive failure via oxidative stress
3360	1445: Increase, LPO	55: Cell injury/death	Oct 8, 2024	Oct 8, 2024	None
3364	1445: Increase, LPO	1505: Cell cycle, disrupted	Oct 8, 2024	Oct 8, 2024	None
3569	1445: Increase, LPO	1994: Ferroptosis	Aug 13, 2025	Aug 13, 2025	None
3713	1445: Increase, LPO	902: Inflammation, Liver	Jan 19, 2026	Jan 19, 2026	1 AOP 615: Suppression of Keap1 cysteine oxidation leading to liver inflammation
169	161: Increase, Liver and splenic hemosiderosis	173: N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number	Nov 29, 2016	Dec 3, 2016	1 AOP 31: Oxidation of iron in hemoglobin leading to hematotoxicity
3729	344: Increase, Liver fibrosis	2406: Increase, Regenerative nodule formation	Feb 10, 2026	Feb 10, 2026	6 AOPs 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
1695	459: Increase, Liver steatosis	1115: Increase, ROS	Nov 14, 2017	Nov 14, 2017	1 AOP 213: Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH)
3218	459: Increase, Liver steatosis	55: Cell injury/death	May 14, 2024	Jan 30, 2025	1 AOP 494: AhR activation leading to liver fibrosis
3592	459: Increase, Liver steatosis	2019: Non-alcoholic fatty liver disease	Aug 16, 2025	Aug 16, 2025	1 AOP 591: DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration
3724	459: Increase, Liver steatosis	2405: Increase, Hepatocellular lipotoxicity	Feb 10, 2026	Feb 10, 2026	6 AOPs 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
461	414: Increase, Luteinizing hormone (LH)	416: Increase proliferation, Leydig cell	Nov 29, 2016	Dec 3, 2016	1 AOP 51: PPARα activation leading to impaired fertility in adult male rodents
3461	2302: Increase, Malformations	351: Increased Mortality	Dec 24, 2024	Dec 24, 2024	1 AOP 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.
3641	2373: Increase, Mis-timed EcR-responsive NR cascade	988: Decrease, Circulating ETH	Sep 29, 2025	Sep 29, 2025	1 AOP 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade
2119	1785: Increase, Mitochondrial ATP synthase antagonism	1477: OXPHOS, decreased	May 8, 2020	May 8, 2020	None
2229	1785: Increase, Mitochondrial ATP synthase antagonism	1771: Decrease, ATP pool	Dec 4, 2020	Dec 4, 2020	2 AOPs 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
2183	1811: Increase, Complex III dysfunction	1812: Increase, Cyt c release	Nov 2, 2020	Nov 2, 2020	None
363	177: Increase, Mitochondrial dysfunction	55: Cell injury/death	Nov 29, 2016	Nov 29, 2016	4 AOPs 144: Endocytic lysosomal uptake leading to liver fibrosis 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 530: Endocytotic lysosomal uptake leads to intestinal barrier disruption 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction
582	177: Increase, Mitochondrial dysfunction	386: Neuronal network function, Decreased	Nov 29, 2016	Dec 3, 2016	1 AOP 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1

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