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Showing 1926 to 1950 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1953	1661: Homocysteine increases	1662: plasma homocysteine increases	Jun 14, 2019	Jun 14, 2019	None
1959	1661: Homocysteine increases	1665: Plasma HCY level	Jul 3, 2019	Jul 3, 2019	1 AOP 301: Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis
2062	1750: Increased inflammatory immune responses	1748: Increase, the risk of acute respiratory failure	Mar 10, 2020	Mar 10, 2020	1 AOP 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality
2513	1750: Increased inflammatory immune responses	1934: Heart attack	Oct 28, 2021	Oct 28, 2021	None
2029	1721: Increased monitor peptide	1722: Increased blood CCK level	Jan 8, 2020	Jan 8, 2020	1 AOP 316: Trypsin inhibition leading to pancreatic acinar cell tumors
2940	2149: Increased intracelluar Iron	191: Neuronal dysfunction	Jun 15, 2023	Jun 15, 2023	1 AOP 498: Increased LCN2/iron complex leading to neurological disorders
3313	2149: Increased intracelluar Iron	1392: Increase, Oxidative Stress	Jul 23, 2024	Jul 23, 2024	1 AOP 501: Excessive iron accumulation leading to neurological disorders
2627	1985: Increased Kisspeptin levels in AVPV	1986: Decreased, Gonadotropins	Apr 5, 2022	Aug 15, 2022	1 AOP 445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
3714	1985: Increased Kisspeptin levels in AVPV	1047: Increased, secretion of GnRH from hypothalamus	Jan 29, 2026	Feb 10, 2026	1 AOP 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release
2939	2148: Increased LCN2/iron complex	2149: Increased intracelluar Iron	Jun 15, 2023	Jun 15, 2023	1 AOP 498: Increased LCN2/iron complex leading to neurological disorders
2900	2130: increased lipid accumulation	2125: Increased fat mass	May 4, 2023	May 4, 2023	1 AOP 493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
3398	2278: LMNA Mutation	2279: Structural changes in lamin A/C	Nov 20, 2024	Nov 20, 2024	1 AOP 550: Increased LMNA gene mutation leading to heart failure
1322	1256: increased mantel display	1257: Induced parturition	Jan 13, 2017	Jan 13, 2017	2 AOPs 203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline 204: 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase
2610	1980: Increase,miRNA levels	1981: Decrease,SIRT1(sirtuin 1) levels	Mar 22, 2022	Aug 27, 2023	1 AOP 443: DNA damage and mutations leading to Metastatic Breast Cancer
2816	2081: Modified Proteins	2083: Cataracts	Dec 18, 2022	Mar 8, 2024	1 AOP 478: Deposition of energy leading to occurrence of cataracts
200	351: Increased Mortality	361: Decline, Population	Nov 29, 2016	Dec 3, 2016	None
428	351: Increased Mortality	442: Decreased, Population trajectory	Nov 29, 2016	Dec 20, 2019	None
756	351: Increased Mortality	765: Decreased, population 1	Nov 29, 2016	Dec 3, 2016	1 AOP 113: Glutamate-gated chloride channel activation leading to acute mortality
1191	351: Increased Mortality	997: Decreased, Population size	Nov 29, 2016	Dec 3, 2016	None
2013	351: Increased Mortality	360: Decrease, Population growth rate	Dec 20, 2019	Jul 8, 2022	14 AOPs 312: Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement 16: Acetylcholinesterase inhibition leading to acute mortality 155: Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation 156: Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation 157: Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation 158: Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure 364: Thyroperoxidase inhibition leading to altered visual function via decreased eye size 365: Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning 399: Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos) 410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear 536: Estrogen receptor agonism leading to reduced survival and population growth due to renal failure 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.
2486	351: Increased Mortality	679: Decline, Population trajectory	Oct 8, 2021	Oct 8, 2021	None
1858	1602: Activation, Muscarinic Acetylcholine Receptors	1350: Increased, glutamate	Feb 13, 2019	Feb 13, 2019	None
1889	1602: Activation, Muscarinic Acetylcholine Receptors	1623: Occurrence, Focal Seizure	Apr 22, 2019	Sep 3, 2023	1 AOP 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration
3402	1602: Activation, Muscarinic Acetylcholine Receptors	1098: Increased, blood potassium concentration	Nov 20, 2024	Nov 20, 2024	1 AOP 551: Increased Muscarinic M2 Receptor leading to Arrhythmia
3431	1602: Activation, Muscarinic Acetylcholine Receptors	698: Altered, Action Potential	Nov 22, 2024	Nov 22, 2024	1 AOP 559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias

Key Event Relationships (KERs)

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