AOP-Wiki

API

All KERs

Showing 2951 to 2975 of 3164 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1103	1065: Activation, ERα	1066: Promotion, SIX1 positive progenitor cells in endometrium	Nov 29, 2016	Dec 3, 2016	None
2665	1065: Activation, ERα	1985: Increased Kisspeptin levels in AVPV	Jun 6, 2022	Jun 2, 2026	5 AOPs 445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle
2666	1065: Activation, ERα	1986: Decreased, Gonadotropins	Jun 6, 2022	Aug 15, 2022	1 AOP 445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
2730	1065: Activation, ERα	1991: Impaired, Reproduction	Aug 15, 2022	Aug 15, 2022	1 AOP 445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
2969	1065: Activation, ERα	2152: Epigenetic modification process	Jul 27, 2023	Apr 28, 2025	1 AOP 503: Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation
3646	1065: Activation, ERα	968: Decreased, release of kisspeptin from AVPV neurons	Oct 2, 2025	Jun 2, 2026	1 AOP 609: Activation, estrogen receptor alpha leads to prolonged estrus cycle via decreased kisspeptin release
3773	1065: Activation, ERα	2417: Increased, differentiation to ovaries	Apr 17, 2026	Jun 24, 2026	1 AOP 641: Activation, estrogen receptor alpha leads to increased, phenotypic female-biased sex ratio via increased, differentiation to ovaries
936	913: Activation, Epidermal Growth Factor Receptor	914: Decreased ciliated cell apoptosis	Nov 29, 2016	Dec 3, 2016	None
939	913: Activation, Epidermal Growth Factor Receptor	923: Increased goblet cell proliferation	Nov 29, 2016	Dec 3, 2016	None
942	913: Activation, Epidermal Growth Factor Receptor	919: Occurrence, Transdifferentiation of ciliated epithelial cells	Nov 29, 2016	Nov 29, 2016	None
946	913: Activation, Epidermal Growth Factor Receptor	924: Activation, Sp1	Nov 29, 2016	Dec 3, 2016	None
962	941: Activation, EGFR	914: Decreased ciliated cell apoptosis	Nov 29, 2016	Aug 27, 2021	None
964	941: Activation, EGFR	924: Activation, Sp1	Nov 29, 2016	Aug 11, 2021	None
965	941: Activation, EGFR	919: Occurrence, Transdifferentiation of ciliated epithelial cells	Nov 29, 2016	Aug 25, 2021	None
970	941: Activation, EGFR	923: Increased goblet cell proliferation	Nov 29, 2016	Aug 27, 2021	None
986	941: Activation, EGFR	962: Increase, Mucin production	Nov 29, 2016	Mar 9, 2023	1 AOP 148: EGFR Activation Leading to Decreased Lung Function
2469	941: Activation, EGFR	920: Goblet cell metaplasia	Aug 25, 2021	Aug 27, 2021	None
2857	941: Activation, EGFR	2117: Increase, goblet cell number	Mar 15, 2023	Mar 16, 2023	1 AOP 148: EGFR Activation Leading to Decreased Lung Function
2987	2164: Activation, Dll4-Notch pathway	1928: increased，Vascular endothelial dysfunction	Aug 20, 2023	Aug 20, 2023	2 AOPs 508: Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
3011	2164: Activation, Dll4-Notch pathway	2161: Increase, Vascular disrupting effects	Aug 21, 2023	Aug 21, 2023	None
379	398: Activation, Dendritic Cells	272: Activation/Proliferation, T-cells	Nov 29, 2016	Aug 22, 2022	2 AOPs 40: Covalent Protein binding leading to Skin Sensitisation 39: Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response
711	715: Activation, Constitutive androstane receptor	716: Increase, cell proliferation (hepatocytes)	Nov 29, 2016	Dec 3, 2016	None
1268	715: Activation, Constitutive androstane receptor	1214: Altered expression of hepatic CAR-dependent genes	Nov 29, 2016	Dec 21, 2018	1 AOP 107: Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat
77	66: Activation, ChREBP	89: Synthesis, De Novo Fatty Acid (FA)	Nov 29, 2016	Dec 3, 2016	1 AOP 34: LXR activation leading to hepatic steatosis
483	66: Activation, ChREBP	458: Increased, De Novo FA synthesis	Nov 29, 2016	Dec 3, 2016	1 AOP 58: NR1I3 (CAR) suppression leading to hepatic steatosis

Key Event Relationships (KERs)

All KERs