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Showing 3126 to 3150 of 3164 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1144	560: Abnormal, Foraging activity and behavior	1107: Weakened, Colony	Nov 29, 2016	Dec 3, 2016	5 AOPs 77: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 88: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste 180: Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure 182: Weather event contributes abnormal foraging leading to colony loss/failure 183: Nosema infection increases energetic demands leading to colony loss/failure
1148	560: Abnormal, Foraging activity and behavior	564: Abnormal, Roll change within caste	Nov 29, 2016	Dec 3, 2016	None
1150	560: Abnormal, Foraging activity and behavior	1108: Abnormal, Role change within caste	Nov 29, 2016	Dec 3, 2016	2 AOPs 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure
3459	2301: Abnormal, Behavior	566: impaired, Larval development	Dec 24, 2024	Dec 24, 2024	1 AOP 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.
2997	2166: Abnormal expression of NO	1928: increased，Vascular endothelial dysfunction	Aug 20, 2023	Aug 20, 2023	1 AOP 510: Demethylation of PPAR promotor leading to vascular disrupting effects
3122	2208: Aberrant, synaptic formation and plasticity	386: Neuronal network function, Decreased	Jan 25, 2024	Jan 25, 2024	1 AOP 522: Estrogen antagonism leading to increased risk of autism-like behavior
3253	2208: Aberrant, synaptic formation and plasticity	341: Impairment, Learning and memory	Jun 19, 2024	Jun 19, 2024	1 AOP 535: Binding and activation of GPER leading to learning and memory impairments
356	382: Aberrant, Dendritic morphology	385: Synaptogenesis, Decreased	Nov 29, 2016	Nov 29, 2016	1 AOP 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
1495	1387: 7α-hydroxypregnenolone synthesis in the brain, decreased	1389: Locomotor activity, decreased	May 2, 2017	May 17, 2017	1 AOP 218: Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity
1496	1387: 7α-hydroxypregnenolone synthesis in the brain, decreased	1388: Dopamine release in the brain, decreased	May 2, 2017	May 25, 2017	2 AOPs 218: Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity 219: Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior
1498	1387: 7α-hydroxypregnenolone synthesis in the brain, decreased	1390: Sexual behavior, decreased	May 3, 2017	May 17, 2017	1 AOP 219: Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior
3464	2250: HSD17B2 inhibition	2251: Increased E2 availability	Jan 2, 2025	Jan 2, 2025	1 AOP 565: 17β-Hydroxysteroid dehydrogenase 2, inhibition leading to activation, estrogen receptor alpha
2158	1796: 11β-hydroxylase inhibition	1756: Decreased, 11KT	Jul 13, 2020	Oct 3, 2025	None
2275	1796: 11β-hydroxylase inhibition	1835: Cortisol and 11β-(OH) testosterone decreased	Feb 9, 2021	Feb 9, 2021	1 AOP 349: Inhibition of 11β-hydroxylase leading to decresed population trajectory
312	281: T4 in serum, Decreased	280: T4 in neuronal tissue, Decreased	Nov 29, 2016	Apr 4, 2019	7 AOPs 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 65: XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 134: Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 8: Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
403	281: T4 in serum, Decreased	402: Cognitive function, decreased	Nov 29, 2016	Apr 27, 2026	4 AOPs 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 65: XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 134: Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
1039	281: T4 in serum, Decreased	1007: Reduced, Anterior swim bladder inflation	Nov 29, 2016	Oct 10, 2022	1 AOP 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation
1143	281: T4 in serum, Decreased	1093: Decreased, Thyroxine (T4) in tissues	Nov 29, 2016	Sep 3, 2020	None
1387	281: T4 in serum, Decreased	756: Hippocampal gene expression, Altered	Mar 24, 2017	Aug 11, 2018	1 AOP 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
1388	281: T4 in serum, Decreased	757: Hippocampal anatomy, Altered	Mar 24, 2017	Aug 11, 2018	1 AOP 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
1389	281: T4 in serum, Decreased	758: Hippocampal Physiology, Altered	Mar 24, 2017	Aug 11, 2018	1 AOP 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
2038	281: T4 in serum, Decreased	1003: Decreased, Triiodothyronine (T3)	Feb 19, 2020	Oct 10, 2022	4 AOPs 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure 364: Thyroperoxidase inhibition leading to altered visual function via decreased eye size 365: Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning
2168	281: T4 in serum, Decreased	1101: Altered, Amphibian metamorphosis	Aug 25, 2020	Aug 25, 2020	8 AOPs 175: Thyroperoxidase inhibition leading to altered amphibian metamorphosis 176: Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis 194: Hepatic nuclear receptor activation leading to altered amphibian metamorphosis 366: Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis 367: Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis 188: Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis 192: Pendrin inhibition leading to altered amphibian metamorphosis 193: Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis
2420	281: T4 in serum, Decreased	753: Increase, Thyroid-stimulating hormone (TSH)	Jul 7, 2021	Jul 7, 2021	None
2422	281: T4 in serum, Decreased	1023: Increased, Thyroid-stimulating hormone (TSH)	Jul 7, 2021	Jul 7, 2021	3 AOPs 162: Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse 110: Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) 119: Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse)

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