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Showing 1451 to 1475 of 3164 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3132	177: Increase, Mitochondrial dysfunction	1928: increased，Vascular endothelial dysfunction	Feb 21, 2024	Feb 21, 2024	2 AOPs 509: Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
3134	177: Increase, Mitochondrial dysfunction	709: Increase, Cytotoxicity (renal tubular cell)	Feb 28, 2024	Mar 6, 2024	2 AOPs 256: Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity 437: Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity
3136	177: Increase, Mitochondrial dysfunction	1585: Proteasomal dysfunction	Feb 29, 2024	Feb 29, 2024	1 AOP 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
3141	177: Increase, Mitochondrial dysfunction	1115: Increase, ROS	Mar 6, 2024	Apr 11, 2024	3 AOPs 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis 273: Mitochondrial complex inhibition leading to liver injury 472: DNA adduct formation leading to kidney failure
3146	177: Increase, Mitochondrial dysfunction	1262: Apoptosis	Mar 13, 2024	Mar 13, 2024	3 AOPs 205: AOP from chemical insult to cell death 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans 595: Emerging OPFRS reproductive outcome pathway
3149	177: Increase, Mitochondrial dysfunction	1263: Necrosis	Mar 13, 2024	Mar 13, 2024	1 AOP 205: AOP from chemical insult to cell death
3150	177: Increase, Mitochondrial dysfunction	1762: cell injury	Mar 13, 2024	Mar 13, 2024	1 AOP 335: AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment
3152	177: Increase, Mitochondrial dysfunction	1817: Apoptotic cell death	Mar 13, 2024	Mar 13, 2024	1 AOP 362: Immune mediated hepatitis
3153	177: Increase, Mitochondrial dysfunction	1815: Increase, ER stress	Mar 13, 2024	Mar 13, 2024	1 AOP 362: Immune mediated hepatitis
3155	177: Increase, Mitochondrial dysfunction	833: Occurrence, Cytoplasmic vacuolization (hepatocyte)	Mar 13, 2024	Mar 13, 2024	1 AOP 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
3156	177: Increase, Mitochondrial dysfunction	835: Occurrence, Ballooning degeneration (hepatocyte)	Mar 13, 2024	Mar 13, 2024	1 AOP 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
3157	177: Increase, Mitochondrial dysfunction	837: Occurrence, Cytoplasmic vacuolization (kupffer cell)	Mar 13, 2024	Mar 13, 2024	1 AOP 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
3158	177: Increase, Mitochondrial dysfunction	836: Occurrence, Cytoplasmic vacuolization (Bile duct cell)	Mar 13, 2024	Mar 13, 2024	1 AOP 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
3161	177: Increase, Mitochondrial dysfunction	2144: Impaired insulin signaling	Mar 13, 2024	Mar 13, 2024	1 AOP 497: ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome
3164	177: Increase, Mitochondrial dysfunction	1917: Altered expression of NRF2 pathway-dependent genes	Mar 14, 2024	Mar 14, 2024	1 AOP 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
3165	177: Increase, Mitochondrial dysfunction	202: Inhibition, Nuclear factor kappa B (NF-kB)	Mar 14, 2024	Mar 14, 2024	1 AOP 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
3767	177: Increase, Mitochondrial dysfunction	188: Neuroinflammation	Apr 2, 2026	Apr 2, 2026	1 AOP 636: Increase in reactive oxygen species (ROS) leading to human amyotrophic lateral sclerosis (ALS)
2183	1811: Increase, Complex III dysfunction	1812: Increase, Cyt c release	Nov 2, 2020	Nov 2, 2020	None
2119	1785: Increase, Mitochondrial ATP synthase antagonism	1477: OXPHOS, decreased	May 8, 2020	May 8, 2020	None
2229	1785: Increase, Mitochondrial ATP synthase antagonism	1771: Decrease, ATP pool	Dec 4, 2020	Dec 4, 2020	2 AOPs 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
3641	2373: Increase, Mis-timed EcR-responsive NR cascade	988: Decrease, Circulating ETH	Sep 29, 2025	Sep 29, 2025	1 AOP 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade
3461	2302: Increase, Malformations	351: Increased Mortality	Dec 24, 2024	Dec 24, 2024	1 AOP 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.
461	414: Increase, Luteinizing hormone (LH)	416: Increase proliferation, Leydig cell	Nov 29, 2016	Dec 3, 2016	1 AOP 51: PPARα activation leading to impaired fertility in adult male rodents
1695	459: Increase, Liver steatosis	1115: Increase, ROS	Nov 14, 2017	Nov 14, 2017	1 AOP 213: Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH)
3218	459: Increase, Liver steatosis	55: Cell injury/death	May 14, 2024	Jan 30, 2025	1 AOP 494: AhR activation leading to liver fibrosis

Key Event Relationships (KERs)

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