Key Event Relationships (KERs)

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Showing 2676 to 2700 of 3081 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
2806 388: Overactivation, NMDARs 2078: Loss of drebrin Dec 11, 2022 Jul 17, 2024 None
3038 388: Overactivation, NMDARs 1527: Increase, Cell membrane depolarization Sep 14, 2023 Sep 14, 2023
3068 388: Overactivation, NMDARs 12: AchE Inhibition Oct 17, 2023 Oct 17, 2023
3069 388: Overactivation, NMDARs 618: Decreased, Neuronal network function in adult brain Oct 17, 2023 Oct 17, 2023
3071 388: Overactivation, NMDARs 188: Neuroinflammation Oct 17, 2023 Oct 17, 2023
2404 1886: Overexpression of rasl11b 1821: Decrease, Cell proliferation May 28, 2021 Dec 12, 2021
661 664: Overwhelmed, Mitochondrial DNA repair mechanisms 570: Accumulation, Damaged mitochondrial DNA Nov 29, 2016 Dec 3, 2016
1852 1596: Oxidation of DNA 1599: Inflammatory events Feb 4, 2019 Feb 4, 2019 None
1850 1594: Oxidation of membrane lipids 1599: Inflammatory events Feb 4, 2019 Jul 9, 2019
954 926: Oxidation, Glutathione 927: S-Glutathionylation, eNOS Nov 29, 2016 Sep 28, 2017 None
2459 926: Oxidation, Glutathione 1115: Increase, ROS Aug 5, 2021 Aug 5, 2021
864 844: Oxidation, Uroporphyrinogen 846: Accumulation, Highly carboxylated porphyrins Nov 29, 2016 Nov 29, 2016 None
865 844: Oxidation, Uroporphyrinogen 845: Inhibition, UROD Nov 29, 2016 May 30, 2018
1851 1595: Oxidation/denatuation of membrane proteins 1599: Inflammatory events Feb 4, 2019 Jul 9, 2019
1669 1477: OXPHOS, decreased 40: Mitochondrial ATP production, decreased Oct 10, 2017 Oct 10, 2017
1810 1477: OXPHOS, decreased 1562: Decreased Na/K ATPase activity Dec 20, 2018 Dec 20, 2018
2095 1477: OXPHOS, decreased 1771: Decrease, ATP pool Apr 30, 2020 Apr 30, 2020
2346 1477: OXPHOS, decreased 1808: Decrease, ATP synthase activity Apr 11, 2021 Apr 11, 2021 None
2713 1477: OXPHOS, decreased 1392: Increase, Oxidative Stress Jul 25, 2022 Jul 25, 2022 None
1282 1231: Oxidization of biomolecules, Lipid bilayer and cellular proteins 1215: TRPA1 activation, TRPA1 Receptor Nov 29, 2016 Dec 3, 2016 None
1285 1231: Oxidization of biomolecules, Lipid bilayer and cellular proteins 1236: Generation of novel epitopes , Antigen presentation Nov 29, 2016 Dec 3, 2016 None
1286 1231: Oxidization of biomolecules, Lipid bilayer and cellular proteins 1234: Production of nerve growth factor , Epithelial irritation Nov 29, 2016 Dec 3, 2016 None
1711 1504: p21 (CDKN1A) expression, increase 1505: Cell cycle, disrupted Jan 21, 2018 Jul 25, 2018 None
3083 896: Parkinsonian motor deficits 350: Increase, Mortality Oct 17, 2023 Oct 17, 2023
236 209: Peptide Oxidation 134: Increase, Kupffer cell activation Nov 29, 2016 Dec 3, 2016 None