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Showing 701 to 725 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2763	1446: Decrease, Coupling of OXPHOS	2064: Increase, Cytosolic Ca	Sep 13, 2022	Sep 13, 2022	1 AOP 265: Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium
2793	1446: Decrease, Coupling of OXPHOS	2070: Increase, Glycolysis	Nov 1, 2022	Nov 1, 2022	1 AOP 267: Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion
2796	1446: Decrease, Coupling of OXPHOS	2072: Increase, Mitochondrial swelling	Nov 1, 2022	Nov 1, 2022	1 AOP 268: Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling
3495	1446: Decrease, Coupling of OXPHOS	1115: Increase, ROS	Feb 25, 2025	Feb 25, 2025	2 AOPs 534: Succinate dehydrogenase (SDH) inhibition leads to cancer through oxidative stress 613: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via increased reactive oxygen species production
1743	1523: Decrease, Cuticular chitin content	1524: Increase, Premature molting	May 24, 2018	Feb 17, 2021	3 AOPs 360: Chitin synthase 1 inhibition leading to mortality 361: Sulfonylureareceptor binding leading to mortality 606: Ecdysone receptor antagonism leading to mortality via inhibition of chitin synthase 1
1011	996: Decrease, Digestion of old cuticle	990: Increase, Incomplete ecdysis	Nov 29, 2016	Dec 3, 2016	None
2171	996: Decrease, Digestion of old cuticle	1524: Increase, Premature molting	Oct 21, 2020	Oct 21, 2020	2 AOPs 358: Chitinase inhibition leading to mortality 359: Chitobiase inhibition leading to mortality
1881	1613: Decrease, DHT level	219: Reduction, Plasma 17beta-estradiol concentrations	Apr 18, 2019	Apr 18, 2019	1 AOP 289: Inhibition of 5α-reductase leading to impaired fecundity in female fish
1935	1613: Decrease, DHT level	1614: Decrease, AR activation	Jun 3, 2019	Apr 5, 2024	4 AOPs 288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) 305: 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring 571: 5α-reductase inhibition leading to hypospadias in male (mammalian) offspring 576: 5α-reductase inhibition leading to increased nipple retention (NR) in male (rodent) offspring
3172	1613: Decrease, DHT level	2213: Impaired, urethral tube closure	Mar 20, 2024	Dec 3, 2024	1 AOP 527: Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Hypospadias, increased
2745	2052: Decrease, dopa decarboxylase	2053: Increase, Defects in tanning of new cuticle	Aug 28, 2022	Aug 28, 2022	1 AOP 466: Doda decarboxylase leading to mortality
1087	1056: Decrease, E2 blood concentrations at hypothalamus	1047: Increased, secretion of GnRH from hypothalamus	Nov 29, 2016	Dec 3, 2016	1 AOP 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
1348	1267: Decrease, Ecdysis motor program activity	1268: Decrease, Excitatory postsynaptic potential	Feb 9, 2017	Feb 9, 2017	None
3639	1267: Decrease, Ecdysis motor program activity	993: Decrease, Abdominal muscle contraction	Sep 29, 2025	Sep 29, 2025	3 AOPs 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade 343: Ecdysone receptor antagonism leading to mortality via mis-timed ecdysone receptor-responsive nuclear receptor cascade
3059	2196: Decrease, elavl3	352: N/A, Neurodegeneration	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Neuron defect induced early behavioral change
1349	1268: Decrease, Excitatory postsynaptic potential	993: Decrease, Abdominal muscle contraction	Feb 9, 2017	Feb 9, 2017	None
1995	1699: Decease, expression of GnRHR	3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells	Oct 30, 2019	Oct 30, 2019	1 AOP 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
2726	2041: Decrease, facial prominence outgrowth	2042: orofacial cleft	Jul 28, 2022	May 22, 2023	2 AOPs 460: Antagonism of Smoothened receptor leading to orofacial clefting 491: Decrease, GLI1/2 target gene expression leads to orofacial clefting
190	179: Decrease, Fatty acid β-oxidation	327: Accumulation, Fatty acid	Nov 29, 2016	Dec 3, 2016	2 AOPs 36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
617	179: Decrease, Fatty acid β-oxidation	459: Increase, Liver steatosis	Nov 29, 2016	Dec 3, 2016	None
2931	179: Decrease, Fatty acid β-oxidation	1816: Mitochondrial dysfunction EMPTY	May 25, 2023	May 25, 2023	None
3159	179: Decrease, Fatty acid β-oxidation	177: Increase, Mitochondrial dysfunction	Mar 13, 2024	Mar 13, 2024	1 AOP 497: ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome
3209	179: Decrease, Fatty acid β-oxidation	2225: Disrupted Lipid Storage	May 8, 2024	May 28, 2024	1 AOP 529: Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis
3635	179: Decrease, Fatty acid β-oxidation	1771: Decrease, ATP pool	Sep 8, 2025	Sep 8, 2025	3 AOPs 599: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death 600: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth 601: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation
2208	1824: Decrease, FAO	1771: Decrease, ATP pool	Nov 25, 2020	Nov 25, 2020	None

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