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Showing 876 to 900 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

537	482: Decreased, DHB4/HSD17B4	451: Inhibition, Mitochondrial fatty acid beta-oxidation	Nov 29, 2016	Dec 3, 2016	1 AOP 61: NFE2L2/FXR activation leading to hepatic steatosis
1121	1083: Decreased, Dopaminergic activity	1084: Increased, prolactin secretion	Nov 29, 2016	Dec 3, 2016	1 AOP 170: Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
3254	2233: Decreased, ERαβ heterodimers	1262: Apoptosis	Jun 19, 2024	Jun 19, 2024	1 AOP 535: Binding and activation of GPER leading to learning and memory impairments
1435	1347: Decreased, extracellular serotonin	1326: Increased, 5-HT3	Apr 14, 2017	Apr 14, 2017	1 AOP 214: Network of SSRIs (selective serotonin reuptake inhibitors)
1436	1347: Decreased, extracellular serotonin	1328: Inactivated, 5-HTR	Apr 14, 2017	Apr 14, 2017	5 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 222: Mental stress to agitation 225: Serotonin transporter activation to agitation 224: Serotonin transporter activation to depression
1437	1347: Decreased, extracellular serotonin	1336: Activation, 5-HT2A	Apr 14, 2017	Apr 14, 2017	1 AOP 214: Network of SSRIs (selective serotonin reuptake inhibitors)
1519	1347: Decreased, extracellular serotonin	1325: Decreased, synaptic release	May 30, 2017	May 30, 2017	None
2377	1878: Decreased, Eye size	1643: Altered, Visual function	May 11, 2021	Jan 7, 2022	2 AOPs 399: Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos) 364: Thyroperoxidase inhibition leading to altered visual function via decreased eye size
2406	1878: Decreased, Eye size	351: Increased Mortality	May 28, 2021	May 28, 2021	None
2292	406: decreased, Fertility	360: Decrease, Population growth rate	Mar 26, 2021	Mar 26, 2021	3 AOPs 348: Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory 349: Inhibition of 11β-hydroxylase leading to decresed population trajectory 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis
2387	406: decreased, Fertility	1696: Decrease of egg production and cummulative fecundity	May 12, 2021	May 12, 2021	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
1552	1414: Decreased, GABA	1415: Reduced, GABA-A receptor activation	Jun 2, 2017	Jun 2, 2017	1 AOP 231: presynaptic neuron 2 repression to epilepsy
1245	1179: Decreased, GABA release	1178: Decreased, Chloride conductance	Nov 29, 2016	Dec 3, 2016	None
1188	1145: Decreased, gametogenesis	1141: Decreased, Reproductive Success	Nov 29, 2016	Dec 3, 2016	None
829	819: Decreased, Glomerular filtration	814: Occurrence, Kidney toxicity	Nov 29, 2016	Dec 3, 2016	1 AOP 128: Kidney dysfunction by decreased thyroid hormone
576	578: Decreased, Glucose oxidase enzyme activity	579: Decreased, Hydrogen peroxide production	Nov 29, 2016	Dec 3, 2016	1 AOP 86: Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure
3596	2350: Decreased, Glycolysis	2351: Increased, OXPHOS	Aug 16, 2025	Aug 16, 2025	1 AOP 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis
3465	530: Decreased, GnRH pulsatility/release	531: Decreased, LH Surge	Jan 3, 2025	Jan 3, 2025	1 AOP 566: Decreased, GnRH pulsatility/release leading to estradiol availability, increased via impaired ovulation
3648	530: Decreased, GnRH pulsatility/release	1075: prolonged, estrus cycle	Oct 2, 2025	Jan 28, 2026	1 AOP 609: Activation, estrogen receptor alpha leads to prolonged estrus cycle via decreased kisspeptin release
1108	1071: Decreased, GnRH pulsatility/release in hypothalamus	1072: Decreased, LH Surge from anterior pituitary	Nov 29, 2016	Dec 3, 2016	2 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
2629	1986: Decreased, Gonadotropins	1987: Decreased , Androgen and Progestin	Apr 5, 2022	Apr 5, 2022	1 AOP 445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
3649	1986: Decreased, Gonadotropins	1075: prolonged, estrus cycle	Oct 2, 2025	Jan 28, 2026	1 AOP 609: Activation, estrogen receptor alpha leads to prolonged estrus cycle via decreased kisspeptin release
154	140: Decreased, HSD17B10 expression	8: Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity	Nov 29, 2016	Dec 3, 2016	1 AOP 36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
577	579: Decreased, Hydrogen peroxide production	580: Reduced, Antiseptic incorporated in food	Nov 29, 2016	Dec 3, 2016	1 AOP 86: Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure
3366	2268: Decreased, INSIG1 protein activity	2269: Increased, SREBP2 protein expression	Oct 22, 2024	Feb 10, 2025	2 AOPs 545: Activation, Pregnane-X receptor, NR1l2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased cholesterol synthesis 548: Activation, Pregnane-X receptor, NR1l2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased PCSK9 protein expression

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