Prototypical Stressors

Showing 451 to 475 of 871 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

82	Ibuprofen	Ibuprofen, CAS-RN: 15687-27-1, DTXSID5020732	177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
514	Hydroquinone	Hydroquinone, CAS-RN: 123-31-9, DTXSID7020716	296: Oxidative DNA damage leading to chromosomal aberrations and mutations
454	Hydrogen peroxide	Hydrogen peroxide, CAS-RN: 7722-84-1, DTXSID2020715	8 AOPs 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 615: Suppression of Keap1 cysteine oxidation leading to liver inflammation 324: Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell cycle disruption 325: Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell death 326: Reactive oxygen species leading to growth inhibition via lipid peroxidation and decreased cell proliferation 331: Reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 332: Reactive oxygen species leading to growth inhibition via protein oxidation and decreased cell proliferation 333: Reactive oxygen species leading to growth inhibition via protein oxidation and cell death
132	Hydrocarbons, various		None
446	Hydralazine hydrochloride	Hydralazine hydrochloride, CAS-RN: 304-20-1, DTXSID1044645	2 AOPs 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
623	Hy		None
610	HMR3480		None
504	High LET Radiation		None
503	High LET Ra		None
646	high fat diet		403: combined unhealthy lifestyle factors leading to metabolic syndrome
500	High aspect ratio material		2 AOPs 303: Frustrated phagocytosis-induced lung cancer 409: Frustrated phagocytosis leads to malignant mesothelioma
150	Hexachlorobenzene	Hexachlorobenzene, CAS-RN: 118-74-1, DTXSID2020682	131: Aryl hydrocarbon receptor activation leading to uroporphyria
344	Heptachlor	Heptachlor, CAS-RN: 76-44-8, DTXSID3020679	10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
299	Helicobacter pylori infection		229: Helicobacter pylori to gastric ulcer
276	Helicobacter pylori		217: Gastric ulcer formation
675	Heavy metals (cadmium, lead, copper, iron, nickel)		10 AOPs 499: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis 521: Essential element imbalance leads to reproductive failure via oxidative stress 326: Reactive oxygen species leading to growth inhibition via lipid peroxidation and decreased cell proliferation 539: Decreased Sodium/Potassium ATPase activity leads to Heart failure 325: Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell death 324: Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell cycle disruption 331: Reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 332: Reactive oxygen species leading to growth inhibition via protein oxidation and decreased cell proliferation 333: Reactive oxygen species leading to growth inhibition via protein oxidation and cell death
620	HCoV-NL63		2 AOPs 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality 430: Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation
351	Halothane	Halothane, CAS-RN: 151-67-7, DTXSID4025371	260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
178	Haloperidol	Haloperidol, CAS-RN: 52-86-8, DTXSID4034150	2 AOPs 170: Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat 555: Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure
160	Halogenated phenols		152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
788	Halogenated Hydrocarbons		519: Cardiac ion channels blockade leading to increased incidence of cardiovascular morbidity and mortality
239	Halofenozide	Halofenozide, CAS-RN: 112226-61-6, DTXSID4032619	2 AOPs 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade
151	GW6471		6: Antagonist binding to PPARα leading to body-weight loss
255	Graphene oxide nanoparticles		2 AOPs 210: Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building 237: Substance interaction with lung resident cell membrane components leading to atherosclerosis via acute phase response
530	Gossypol	Gossypol, CAS-RN: 303-45-7, DTXSID5023110	154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response