Prototypical Stressors

Showing 401 to 425 of 853 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

610	HMR3480		None
623	Hy		None
446	Hydralazine hydrochloride	Hydralazine hydrochloride, CAS-RN: 304-20-1, DTXSID1044645	2 AOPs 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
132	Hydrocarbons, various		None
454	Hydrogen peroxide	Hydrogen peroxide, CAS-RN: 7722-84-1, DTXSID2020715	2 AOPs 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 615: Suppression of Keap1 cysteine oxidation leading to liver inflammation
514	Hydroquinone	Hydroquinone, CAS-RN: 123-31-9, DTXSID7020716	296: Oxidative DNA damage leading to chromosomal aberrations and mutations
82	Ibuprofen	Ibuprofen, CAS-RN: 15687-27-1, DTXSID5020732	177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
614	iguratimod	Iguratimod, CAS-RN: 123663-49-0, DTXSID0048971	277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
489	IL-1 receptor antagonist（IL-1Ra）(Anakinra)		277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
438	IL-1 receptor antagonist（IL-1Ra）(Anakinra), anti-IL-1b antibody (Canakinumab), soluble IL-1R (Rilonacept)		None
519	Imiquimod	Imiquimod, CAS-RN: 99011-02-6, DTXSID7041047	313: Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease
119	Immepip		None
678	Impregnation products		None
272	Increase cortisone levels (induced by stress)		3 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 222: Mental stress to agitation
158	Indole	Indole, CAS-RN: 120-72-9, DTXSID0020737	None
27	Indomethacin	1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-Indole-3-acetic acid, CAS-RN: 53-86-1, DTXSID9020740	177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
699	Influenza Virus		506: Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation
613	inguratimod		None
246	Inokosterone	Inokosterone, CAS-RN: 15130-85-5, DTXSID40164756	4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1
377	Insoluble nano-sized particles		237: Substance interaction with lung resident cell membrane components leading to atherosclerosis
508	Interleukin-6	Interleukin-6, CAS-RN: 308067-66-5, DTXSID6041050	309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction
269	Iodine deficiency		None
451	Ionizing Radiation		19 AOPs 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 272: Deposition of energy leading to lung cancer 298: Increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer 216: Deposition of energy leading to population decline via DNA strand breaks and follicular atresia 238: Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction 388: Deposition of ionising energy leading to population decline via programmed cell death 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia 396: Deposition of ionizing energy leads to population decline via impaired meiosis 432: Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia 441: Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation 470: Deposition of energy leads to abnormal vascular remodeling 483: Deposition of Energy Leading to Learning and Memory Impairment 482: Deposition of energy leading to occurrence of bone loss 478: Deposition of energy leading to occurrence of cataracts 550: Increased LMNA gene mutation leading to heart failure
212	iopanoic acid	Iopanoic acid, CAS-RN: 96-83-3, DTXSID6023159	155: Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation
617	IRAK4 inhibitors		277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response