AOP-Wiki

All AOPs

Showing 151 to 175 of 574 AOPs

ID	Title	Point of Contact	License	MIE	AO	OECD Status	OECD Project

185	Queen egg-laying decrease leads to colony loss/failure	Carlie LaLone	BY-SA	None	563: Death/Failure, Colony
186	unknown MIE leading to renal failure and mortality	Kellie Fay	BY-SA	1114: Unknown, MIE	351: Increased Mortality
187	Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage	Undefined	BY-SA	3 MIEs 1134: Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone 1138: Uncoupling of oxidative phosphorylation, Reduced ability to generate ATP 1169: Anticoagulant rodenticide interferes with carboxylation of Gla proteins in bone, Impairment of post-translational modification (carboxylation) of osteocalcin	1136: Impaired recruitment , Population trajectory	Under Development	1.31
188	Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis	Jonathan Haselman	BY-SA	1152: Inhibition, Iodotyrosine deiodinase (IYD)	1101: Altered, Amphibian metamorphosis
189	Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis	Jonathan Haselman	BY-SA	1009: Inhibition, Deiodinase 1	1101: Altered, Amphibian metamorphosis
190	Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis	Jonathan Haselman	BY-SA	1002: Inhibition, Deiodinase 2	1101: Altered, Amphibian metamorphosis
191	Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis	Jonathan Haselman	BY-SA	1153: Inhibition, Deiodinase 3	1101: Altered, Amphibian metamorphosis
192	Pendrin inhibition leading to altered amphibian metamorphosis	Jonathan Haselman	BY-SA	1155: Inhibition, Pendrin	1101: Altered, Amphibian metamorphosis
193	Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis	Jonathan Haselman	BY-SA	1156: Inhibition, Dual oxidase	1101: Altered, Amphibian metamorphosis
194	Hepatic nuclear receptor activation leading to altered amphibian metamorphosis	Jonathan Haselman	BY-SA	1157: Activation, Hepatic nuclear receptor(s)	1101: Altered, Amphibian metamorphosis
195	5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase	Kellie Fay	BY-SA	619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)	1164: Increased, Population
196	Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation	Jeanelle Martinez	BY-SA	1215: TRPA1 activation, TRPA1 Receptor	3 AOs 1223: Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea 1434: Irritation of nasal mucosa inducing sneeze reflex 1226: Increased Respiratory irritability and Chronic Cough,
197	Sodium channel (Nav1.1) inhibition leading to population decline	Kellie Fay	BY-SA	584: Inhibition, sodium channel	None
199	ER mediated breast cancer AOP	Molly M Morgan	BY-SA	None	None
200	Estrogen receptor activation leading to breast cancer	Molly M Morgan	Open for adoption	111: Agonism, Estrogen receptor	1193: N/A, Breast Cancer
201	Juvenile hormone receptor agonism leading to male offspring induction associated population decline	Knut Erik Tollefsen	BY-SA	1205: Activation, Juvenile hormone receptor	3 AOs 1208: Increased, Male offspring 361: Decline, Population 1210: Alteration, Food-web structures
202	Inhibitor binding to topoisomerase II leading to infant leukaemia	Andrea Terron	BY-SA	1252: Binding to (interferes with) topoisomerase II enzyme	1254: Infant leukaemia	WPHA/WNT Endorsed	1.53
203	5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline	Kellie Fay	BY-SA	619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)	2 AOs 1141: Decreased, Reproductive Success 360: Decrease, Population growth rate
204	5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase	Kellie Fay	BY-SA	619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)	2 AOs 1163: Increased, Reproductive Success 1164: Increased, Population
205	AOP from chemical insult to cell death	Mathieu Vinken	BY-SA	3 MIEs 1258: Decompartmentalization 1260: Direct mitochondrial inhibition 1259: narcosis	2 AOs 1262: Apoptosis 1263: Necrosis
206	Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis	Jinhee Choi	All rights reserved	1270: Inactivation of PPARγ	1276: Lung fibrosis	Under Development	1.54
207	NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans	Jinhee Choi	All rights reserved	1174: Activation, NADPH Oxidase	1277: Reproductive failure
208	Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure	Jinhee Choi	All rights reserved	None	1277: Reproductive failure
209	Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP	Jinhee Choi	All rights reserved	None	1291: Hepatotoxicity
210	Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building	Jinhee Choi	All rights reserved	None	1277: Reproductive failure