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All KERs

Showing 251 to 275 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

516	167: Activation, LXR	470: Up Regulation, Acetyl-CoA carboxylase-1 (ACC-1)	Nov 29, 2016	Dec 3, 2016	1 AOP 58: NR1I3 (CAR) suppression leading to hepatic steatosis
3103	167: Activation, LXR	2199: Increased, Expression of LXR activated genes	Dec 7, 2023	Mar 29, 2024	1 AOP 518: Liver X Receptor (LXR) activation leads to liver steatosis
1606	483: Activation, LXR alpha	458: Increased, De Novo FA synthesis	Jul 18, 2017	Jul 18, 2017	1 AOP 61: NFE2L2/FXR activation leading to hepatic steatosis
3376	1198: Activation, Macrophages	1442: Foam cell formation	Oct 30, 2024	Oct 30, 2024	1 AOP 462: Activation of reactive oxygen species leading the atherosclerosis
3588	2345: Activation, MAPK	1293: Activation, FOXO	Aug 16, 2025	Aug 16, 2025	1 AOP 591: DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration
3589	2345: Activation, MAPK	291: Accumulation, Triglyceride	Aug 16, 2025	Aug 16, 2025	1 AOP 591: DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration
2862	1998: Microglia activation	188: Neuroinflammation	Apr 3, 2023	Apr 3, 2023	1 AOP 490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms
3543	2331: Activation, MR	291: Accumulation, Triglyceride	Jul 25, 2025	Jul 25, 2025	1 AOP 580: Mineralocorticoid Receptor Activation Leading to Increased Body Mass Index
3549	2331: Activation, MR	2336: Increase, SREBF1	Jul 25, 2025	Jul 25, 2025	1 AOP 580: Mineralocorticoid Receptor Activation Leading to Increased Body Mass Index
1395	1300: Activation, mTORC1	1302: Activation, L-FABP	Apr 12, 2017	Apr 12, 2017	None
1396	1300: Activation, mTORC1	1303: Activation, HSD17B4	Apr 12, 2017	Apr 12, 2017	None
1399	1300: Activation, mTORC1	1301: Activation, SREBP-1	Apr 12, 2017	Apr 12, 2017	None
1392	1298: Activation, mTORC2	1299: Activation, AKT	Apr 12, 2017	Apr 12, 2017	None
1393	1298: Activation, mTORC2	1300: Activation, mTORC1	Apr 12, 2017	Apr 12, 2017	None
1235	1174: Activation, NADPH Oxidase	209: Peptide Oxidation	Nov 29, 2016	Dec 3, 2016	None
3511	1174: Activation, NADPH Oxidase	1115: Increase, ROS	Apr 3, 2025	Apr 3, 2025	1 AOP 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
581	559: Activation, Nicotinic acetylcholine receptor	177: Increase, Mitochondrial dysfunction	Nov 29, 2016	Dec 3, 2016	5 AOPs 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure 77: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 80: Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure 79: Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1
658	559: Activation, Nicotinic acetylcholine receptor	663: Desensitization, Nicotinic acetylcholine receptor	Nov 29, 2016	Jun 7, 2018	3 AOPs 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 88: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2
1146	559: Activation, Nicotinic acetylcholine receptor	341: Impairment, Learning and memory	Nov 29, 2016	Dec 3, 2016	4 AOPs 77: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure 88: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure
1147	559: Activation, Nicotinic acetylcholine receptor	560: Abnormal, Foraging activity and behavior	Nov 29, 2016	Dec 3, 2016	None
533	479: Activation, NR1H4	480: Activation, SHP	Nov 29, 2016	Dec 3, 2016	1 AOP 61: NFE2L2/FXR activation leading to hepatic steatosis
534	479: Activation, NR1H4	227: Activation, PPARα	Nov 29, 2016	Dec 3, 2016	1 AOP 61: NFE2L2/FXR activation leading to hepatic steatosis
532	478: Activation, NRF2	479: Activation, NR1H4	Nov 29, 2016	Dec 3, 2016	1 AOP 61: NFE2L2/FXR activation leading to hepatic steatosis
1406	478: Activation, NRF2	1304: Activation, FXR	Apr 12, 2017	Apr 12, 2017	None
2719	2030: PARP1	177: Increase, Mitochondrial dysfunction	Jul 28, 2022	Jul 28, 2022	1 AOP 423: Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway

Key Event Relationships (KERs)

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