Key Event Relationships (KERs)

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Showing 2951 to 2975 of 3081 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
3207 2226: Binding PPAR isoforms 2224: Dysregulation of transcriptional expression within PPAR signaling network May 8, 2024 May 8, 2024 None
3208 2226: Binding PPAR isoforms 179: Decrease, Fatty acid β-oxidation May 8, 2024 May 8, 2024 None
3220 2226: Binding PPAR isoforms 2227: Disrupted PPAR isoform nuclear signaling May 14, 2024 May 23, 2024
3399 2279: Structural changes in lamin A/C 2066: Altered Signaling Nov 20, 2024 Nov 20, 2024
1968 1671: Substance - LS interaction 1672: Inhibition of LS function. Jul 3, 2019 Jul 3, 2019 None
1702 1495: Interaction with the lung cell membrane 1496: Increased proinflammatory mediators Jan 5, 2018 Feb 20, 2025
2662 1495: Interaction with the lung cell membrane 1115: Increase, ROS May 25, 2022 May 25, 2022
2663 1495: Interaction with the lung cell membrane 1669: Increased, DNA damage and mutation May 25, 2022 May 25, 2022
2958 1495: Interaction with the lung cell membrane 1438: Increased transcription of genes encoding acute phase proteins Jul 4, 2023 Jan 20, 2025
2959 1495: Interaction with the lung cell membrane 1439: Systemic acute phase response Jul 4, 2023 Jan 20, 2025
2960 1495: Interaction with the lung cell membrane 1443: Atherosclerosis Jul 4, 2023 Feb 19, 2025
3303 2243: Succinate Accumulation 1619: Increase, DNMT inhibition Jul 18, 2024 Jul 18, 2024
3304 2243: Succinate Accumulation 798: Inhibition, Prolyl hydroxylases Jul 18, 2024 Jul 18, 2024
2866 2118: SDH, inhibited 2120: Superoxide generation, increased Apr 3, 2023 May 4, 2023
3233 2118: SDH, inhibited 1446: Decrease, Coupling of OXPHOS May 28, 2024 May 28, 2024
3302 2118: SDH, inhibited 2243: Succinate Accumulation Jul 18, 2024 Jul 18, 2024
3554 2118: SDH, inhibited 177: Increase, Mitochondrial dysfunction Aug 1, 2025 Aug 1, 2025
3273 2120: Superoxide generation, increased 1392: Increase, Oxidative Stress Jul 4, 2024 Jul 4, 2024
1817 1565: Suppressed AP-1 1567: Suppressed DC activation Dec 25, 2018 Dec 25, 2018 None
1819 1567: Suppressed DC activation 1568: Impaired antigen presentation Dec 25, 2018 Dec 25, 2018 None
1826 1573: Suppressed MyD88 986: Impairment of TDAR Jan 6, 2019 Jan 6, 2019 None
1870 1573: Suppressed MyD88 202: Inhibition, Nuclear factor kappa B (NF-kB) Mar 12, 2019 Mar 12, 2019 None
1818 1566: Suppressed NF-kB 1567: Suppressed DC activation Dec 25, 2018 Dec 25, 2018 None
2001 1702: Suppression of T cell activation 202: Inhibition, Nuclear factor kappa B (NF-kB) Nov 17, 2019 Nov 17, 2019 None
2004 1702: Suppression of T cell activation 986: Impairment of TDAR Nov 17, 2019 Mar 2, 2023 None