Key Event Relationships (KERs)

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Showing 3026 to 3050 of 3081 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
2155 1792: TLR4 activation 1283: Activation, TGF-beta pathway Jul 9, 2020 Jul 9, 2020 None
2251 1792: TLR4 activation 1793: AP-1 activation Dec 23, 2020 Dec 23, 2020 None
2542 1963: Torsades de Pointes 1964: Sudden cardiac death Dec 13, 2021 Dec 13, 2021
2852 1963: Torsades de Pointes 351: Increased Mortality Jan 29, 2023 Jan 29, 2023 None
3408 1963: Torsades de Pointes 2281: uncoordinated cardiac contraction Nov 20, 2024 Nov 20, 2024
1589 1438: Increased transcription of genes encoding acute phase proteins 1439: Systemic acute phase response Jun 29, 2017 Jan 17, 2025
1456 1354: Treat, carbamazepine 1353: Binding to VGSC Apr 14, 2017 Apr 14, 2017
3573 2341: TCA cycle, disrupted 40: Mitochondrial ATP production, decreased Aug 13, 2025 Aug 13, 2025
3581 2341: TCA cycle, disrupted 1477: OXPHOS, decreased Aug 15, 2025 Aug 15, 2025 None
3710 2341: TCA cycle, disrupted 178: Mitochondrial electron transport chain, disrupted Jan 7, 2026 Jan 7, 2026
1771 1223: Increased Airway Hyper-responsiveness,Cough, Dyspnea 1226: Respiratory irritability Sep 24, 2018 Sep 24, 2018 None
1275 1220: Excitation, Trigeminal nerve excitation 1221: Cough, Dyspnea, Sneezing, Acute respiratory effect Nov 29, 2016 Dec 3, 2016 None
1276 1220: Excitation, Trigeminal nerve excitation 1223: Increased Airway Hyper-responsiveness,Cough, Dyspnea Nov 29, 2016 Dec 3, 2016 None
1575 1220: Excitation, Trigeminal nerve excitation 1222: SP (Substance P) release, Local increase of SP Jun 23, 2017 Jun 23, 2017
1578 1220: Excitation, Trigeminal nerve excitation 1433: Increased CGRP Jun 23, 2017 Jun 23, 2017
1582 1220: Excitation, Trigeminal nerve excitation 1434: Irritation induced sneezing Jun 23, 2017 Jun 23, 2017
1583 1220: Excitation, Trigeminal nerve excitation 1435: Increased NKA Jun 23, 2017 Jun 23, 2017
1271 1215: TRPA1 activation, TRPA1 Receptor 1218: Opening of calcium channel, Calcium influx Nov 29, 2016 Nov 29, 2016
1284 1215: TRPA1 activation, TRPA1 Receptor 1235: Non-neuronal production of IL-8/CXCL1, Epithelial irritation Nov 29, 2016 Dec 3, 2016 None
1576 1215: TRPA1 activation, TRPA1 Receptor 1236: Generation of novel epitopes , Antigen presentation Jun 23, 2017 Jun 23, 2017 None
1281 1230: TRPV1 activation, TRPV1 1218: Opening of calcium channel, Calcium influx Nov 29, 2016 Nov 29, 2016 None
2028 1720: Inhibition, trypsin 1721: Increased monitor peptide Jan 8, 2020 Jan 8, 2020
1196 1150: Uncarboxylated osteocalcin not incorporated into bone matrix, decreasing bone strength, Imp 1151: Osteoporosis and vascular calcification, Bone deterioration Nov 29, 2016 Dec 3, 2016 None
1168 1122: Under carboxylated clotting factors will not assemble on cell surfaces to form clot, Failur 1130: Failure in vascular repair mechanisms, Unresolved blood loss (hemorrhage) Nov 29, 2016 Dec 3, 2016
1732 1512: Unfolded Protein Response 1513: General Apoptosis Apr 4, 2018 Apr 5, 2018