Key Event Relationships (KERs)

API

Fulltext search has been disabled for Key Event Relationships (KERs) at this time. If you need this feature, send an email to aopwiki@googlegroups.com

Queries Key Event Relationship (KER) titles
Filter by Upstream Key Event title
Filter by Downstream Key Event title
Filter by AOP title
Clear All Filters

Showing 2926 to 2950 of 3081 KERs

Clear Table Filters
ID Upstream Event Downstream Event Creation Date Last Updated AOPs
2314 1738: SARS-CoV-2 cell entry 1858: Increased viral transcription and replication Apr 9, 2021 Apr 9, 2021 None
2361 1738: SARS-CoV-2 cell entry 1870: Sustentacular cells, decrease Apr 26, 2021 Apr 26, 2021 None
2496 1738: SARS-CoV-2 cell entry 1901: IFN-I response, antagonized Oct 24, 2021 Dec 12, 2023
2510 1738: SARS-CoV-2 cell entry 1913: Endothelial cell dysfunction Oct 28, 2021 Oct 28, 2021 None
2661 2006: Secondary genotoxicity 1669: Increased, DNA damage and mutation May 25, 2022 May 25, 2022
1588 1437: Sensing of the stressor 1438: Increased transcription of genes encoding acute phase proteins Jun 29, 2017 Jun 29, 2017 None
2657 1583: Sensory axonal peripheral neuropathy 351: Increased Mortality May 16, 2022 May 16, 2022
3066 1583: Sensory axonal peripheral neuropathy 618: Decreased, Neuronal network function in adult brain Oct 17, 2023 Oct 17, 2023
3067 1583: Sensory axonal peripheral neuropathy 388: Overactivation, NMDARs Oct 17, 2023 Oct 17, 2023 None
1571 1431: Serotonin 1A Receptor Agonism 1426: Release of G Proteins Jun 23, 2017 Jun 23, 2017
1499 1390: Sexual behavior, decreased 1141: Decreased, Reproductive Success May 8, 2017 May 8, 2017
3562 2329: SIX1 gene expression, increased 2330: SIX1 protein expression, increased Aug 5, 2025 Sep 18, 2025
3563 2330: SIX1 protein expression, increased 1066: Promotion, SIX1 positive progenitor cells in endometrium Aug 5, 2025 Sep 18, 2025
2438 1904: six1b expression, increased 1905: eya1 expression, inhibited Jul 14, 2021 Aug 13, 2021
3434 2291: Bradycardia 2292: Altered Cardiac Electrical Conduction Nov 22, 2024 Nov 22, 2024
1279 1222: SP (Substance P) release, Local increase of SP 1224: Non-neuronal production of TNF, Epithelial irritation Nov 29, 2016 Nov 29, 2016 None
1574 1222: SP (Substance P) release, Local increase of SP 1223: Increased Airway Hyper-responsiveness,Cough, Dyspnea Jun 23, 2017 Jun 23, 2017 None
1577 1222: SP (Substance P) release, Local increase of SP 1225: Leukocyte infiltration Jun 23, 2017 Jun 23, 2017 None
1772 1222: SP (Substance P) release, Local increase of SP 1226: Respiratory irritability Sep 24, 2018 Sep 24, 2018
1734 1515: Spermatocyte depletion 1506: Testicular atrophy May 22, 2018 Jul 28, 2021
1024 1000: stabilization, PPAR alpha co-repressor 858: Decreased, PPARalpha transactivation of gene expression Nov 29, 2016 Jun 11, 2018
2141 1788: Status epilepticus 388: Overactivation, NMDARs May 21, 2020 May 21, 2020 None
2782 1788: Status epilepticus 1350: Increased, glutamate Oct 12, 2022 Sep 3, 2023
2783 1788: Status epilepticus 389: Increased, Intracellular Calcium overload Oct 12, 2022 Jul 24, 2023
2017 1706: Stimulation of TLR7/8 1707: Increase of IL-23 Dec 27, 2019 Dec 27, 2019