Key Event Relationships (KERs)

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Showing 2951 to 2975 of 3119 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
1648 495: Repressed expression of steroidogenic enzymes 413: Reduction, Testosterone synthesis in Leydig cells Aug 11, 2017 Aug 11, 2017
3615 495: Repressed expression of steroidogenic enzymes 1690: Decrease, circulating testosterone levels Sep 3, 2025 Sep 3, 2025
3623 495: Repressed expression of steroidogenic enzymes 3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells Sep 3, 2025 Sep 3, 2025 None
2436 1902: Repression of Gbx2 expression 1903: foxi1 expression, increased Jul 14, 2021 Aug 13, 2021
433 445: Respiratory distress/arrest 351: Increased Mortality Nov 29, 2016 Dec 20, 2019
592 445: Respiratory distress/arrest 590: N/A, hypoxia Nov 29, 2016 Dec 3, 2016
378 397: Response, Keratinocytes 398: Activation, Dendritic Cells Nov 29, 2016 Nov 29, 2016 None
380 397: Response, Keratinocytes 272: Activation/Proliferation, T-cells Nov 29, 2016 Dec 3, 2016 None
1915 1637: Retinaldehyde dehydrogenase 1641: retinoic acid May 22, 2019 May 22, 2019
3036 2186: Activation, RyR 1350: Increased, glutamate Sep 8, 2023 Sep 8, 2023
2052 1738: SARS-CoV-2 cell entry 1496: Increased proinflammatory mediators Mar 1, 2020 Mar 1, 2020 None
2302 1738: SARS-CoV-2 cell entry 1848: TLR Activation/Dysregulation Mar 29, 2021 Mar 29, 2021 None
2310 1738: SARS-CoV-2 cell entry 1847: SARS-CoV-2 production Mar 30, 2021 Feb 7, 2023
2314 1738: SARS-CoV-2 cell entry 1858: Increased viral transcription and replication Apr 9, 2021 Apr 9, 2021 None
2361 1738: SARS-CoV-2 cell entry 1870: Sustentacular cells, decrease Apr 26, 2021 Apr 26, 2021 None
2496 1738: SARS-CoV-2 cell entry 1901: IFN-I response, antagonized Oct 24, 2021 Dec 12, 2023
2510 1738: SARS-CoV-2 cell entry 1913: Endothelial cell dysfunction Oct 28, 2021 Oct 28, 2021 None
2661 2006: Secondary genotoxicity 1669: Increased, DNA damage and mutation May 25, 2022 May 25, 2022
1588 1437: Sensing of the stressor 1438: Increased transcription of genes encoding acute phase proteins Jun 29, 2017 Jun 29, 2017 None
2657 1583: Sensory axonal peripheral neuropathy 351: Increased Mortality May 16, 2022 May 16, 2022
3066 1583: Sensory axonal peripheral neuropathy 618: Decreased, Neuronal network function in adult brain Oct 17, 2023 Oct 17, 2023
3067 1583: Sensory axonal peripheral neuropathy 388: Overactivation, NMDARs Oct 17, 2023 Oct 17, 2023 None
1571 1431: Serotonin 1A Receptor Agonism 1426: Release of G Proteins Jun 23, 2017 Jun 23, 2017
1499 1390: Sexual behavior, decreased 1141: Decreased, Reproductive Success May 8, 2017 May 8, 2017
3562 2329: SIX1 gene expression, increased 2330: SIX1 protein expression, increased Aug 5, 2025 Sep 18, 2025