AOPs

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Showing 176 to 200 of 588 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
473 Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin Danielle Beaton BY-SA 1686: Deposition of Energy
472 DNA adduct formation leading to kidney failure Manoe Janssen BY-SA 373: Formation, Pro-mutagenic DNA Adducts 759: Increased, Kidney Failure
471 Neuron defect induced early behavioral change Woo-Keun Kim BY-SA 2195: Increase, CNS Neural cell death
470 Deposition of energy leads to abnormal vascular remodeling Vinita Chauhan BY-SA 1686: Deposition of Energy 2069: Occurrence, Abnormal Vascular Remodeling WPHA/WNT Endorsed 1.89
469 Reactive oxygen speicies overproduction leading to increased digestive morbidity and mortality in generation population Ruiyang Ding BY-SA None None
468 Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death) Laure-Alix Clerbaux BY-SA 1739: Binding to ACE2 1868: Hyperinflammation
467 Knickkopf leading to mortality Donggon Yoo BY-SA 2058: Decrease, 20-hydroxyecdysone None
466 Doda decarboxylase leading to mortality Donggon Yoo BY-SA 2051: Decrease, Tyrosine None
465 Alcohol dehydrogenase leading to reproductive dysfunction Donggon Yoo BY-SA 2045: Increase, Alcohol dehydrogenase None
464 Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits Julia Meerman BY-SA 896: Parkinsonian motor deficits
463 The AOP framwork on silica nanopariticles induced hepatoxicity Tianyu Li BY-SA None None
462 Activation of reactive oxygen species leading the atherosclerosis Hiromi Ohara BY-SA 1115: Increase, Reactive oxygen species None
461 Deposition of ionising energy leads to population decline via impaired oogenesis and spermatogenesis Knut Erik Tollefsen BY-SA None None
460 Antagonism of Smoothened receptor leading to orofacial clefting Jacob Reynolds BY-SA 2027: Antagonism, Smoothened receptor 2042: Increase, Orofacial clefting Under Review 1.101
459 AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals Prakash Patel Open for adoption 18: Activation, AhR 402: Cognitive function, decreased
458 AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals Prakash Patel Open for adoption 18: Activation, AhR 402: Cognitive function, decreased
457 Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine Simon Thomas Open for adoption 2118: Succinate dehydrogenase, inhibited 2119: Increase, Insulin resistance
456 Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity Prarthana Shankar BY-SA 18: Activation, AhR 947: Increase, Early Life Stage Mortality WPHA/WNT Endorsed 1.27
455 Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development Prarthana Shankar BY-SA 18: Activation, AhR WPHA/WNT Endorsed 1.27
454 PM2.5-related AOP frameworks on liver diseases Zhou Du BY-SA None None
453 Reactive oxygen species and subsequent oxidative stress lead to increased incidence of digestive morbidity and mortality in the general population Ruiyang Ding BY-SA None None
452 Adverse outcome pathway of PM-induced respiratory toxicity li qing BY-SA 2007: Non-coding RNA expression profile alteration 2008: Chronic obstructive pulmonary disease
451 Interaction with lung resident cell membrane components leads to lung cancer Penny Nymark BY-SA 1495: Substance interaction with the lung resident cell membrane components 1670: Lung cancer
450 Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality SAROJ AMAR BY-SA 12: Acetylcholinesterase (AchE) Inhibition
449 Ceramide synthase inhibition leading to neural tube defects Lola Bajard BY-SA 2023: Inhibition of Ceramide Synthase 1561: Neural tube defects