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Showing 2976 to 3000 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2927	1702: Suppression of T cell activation	1700: Impaired IL-1R1 signaling	May 24, 2023	May 24, 2023	None
2928	1702: Suppression of T cell activation	984: Impairment, T-cell dependent antibody response	May 24, 2023	May 25, 2023	1 AOP 277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
2027	1718: Suppression of IL-4 production	1719: Impairment, TDAR	Jan 5, 2020	Apr 4, 2021	1 AOP 315: Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response
3684	2385: Suppression of Keap1 cysteine oxidation	1417: NFE2/Nrf2 repression	Nov 4, 2025	Nov 4, 2025	1 AOP 615: Suppression of Keap1 cysteine oxidation leading to liver inflammation
2026	1717: Suppression of STAT5 binding to cytokine gene promoters	1718: Suppression of IL-4 production	Jan 5, 2020	Mar 30, 2021	1 AOP 315: Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response
476	456: Suppression, Constitutive androstane receptor, NR1l3	167: Activation, LXR	Nov 29, 2016	Dec 3, 2016	1 AOP 58: NR1I3 (CAR) suppression leading to hepatic steatosis
477	456: Suppression, Constitutive androstane receptor, NR1l3	228: demethylation, PPARg promoter	Nov 29, 2016	Dec 3, 2016	1 AOP 58: NR1I3 (CAR) suppression leading to hepatic steatosis
1086	1046: Suppression, Estrogen receptor (ER) activity	1056: Decrease, E2 blood concentrations at hypothalamus	Nov 29, 2016	Dec 3, 2016	1 AOP 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
2580	1046: Suppression, Estrogen receptor (ER) activity	1047: Increased, secretion of GnRH from hypothalamus	Feb 26, 2022	Mar 1, 2022	1 AOP 440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
1255	1202: Suppression, IL-2 and IL-4 production	979: Interference, nuclear localization of NFAT	Nov 29, 2016	Dec 3, 2016	None
1510	1202: Suppression, IL-2 and IL-4 production	984: Impairment, T-cell dependent antibody response	May 19, 2017	Jun 27, 2021	1 AOP 154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
570	403: Suppression, Immune system	576: Increased, Viral susceptibility	Nov 29, 2016	Dec 3, 2016	2 AOPs 84: Suppression of immune system contributes to impaired development and leads to colony loss/failure 85: Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure
388	152: Suppression, Inflammatory cytokines	168: Decreased, Lymphocytes	Nov 29, 2016	Dec 3, 2016	1 AOP 14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
1258	1203: Suppression, Suppression of production of cytotoxic T-cells	984: Impairment, T-cell dependent antibody response	Nov 29, 2016	Dec 3, 2016	None
1260	1203: Suppression, Suppression of production of cytotoxic T-cells	986: Impairment of TDAR	Nov 29, 2016	Dec 3, 2016	None
1259	1204: Suppression, Suppression of T-cell dependent antibody production	986: Impairment of TDAR	Nov 29, 2016	Dec 3, 2016	None
1823	983: Suppression, Suppression of T-cell dependent antibody response (TDAR)	986: Impairment of TDAR	Dec 25, 2018	Dec 25, 2018	None
2362	1870: Sustentacular cells, decrease	1871: olfacotry neurons, decrease	Apr 26, 2021	Apr 26, 2021	1 AOP 394: SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia)
2365	1870: Sustentacular cells, decrease	1873: anosmia	Apr 26, 2021	Apr 26, 2021	1 AOP 394: SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia)
2504	1944: Dysfunctional synapses	386: Neuronal network function, Decreased	Oct 26, 2021	Oct 26, 2021	2 AOPs 429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
2808	1944: Dysfunctional synapses	341: Impairment, Learning and memory	Dec 11, 2022	Dec 11, 2022	None
3065	1944: Dysfunctional synapses	1582: Impaired axonial transport	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Neuron defect induced early behavioral change
3078	1944: Dysfunctional synapses	637: impaired, Learning and memory	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Neuron defect induced early behavioral change
110	89: Synthesis, De Novo Fatty Acid (FA)	291: Accumulation, Triglyceride	Nov 29, 2016	Mar 29, 2024	2 AOPs 34: LXR activation leading to hepatic steatosis 518: Liver X Receptor (LXR) activation leads to liver steatosis
1590	1439: Systemic acute phase response	1440: HDL-SAA formation	Jun 29, 2017	Jun 29, 2017	None

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