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Showing 1701 to 1725 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2465	1607: Increase, Necrosis	759: Increased, Kidney Failure	Aug 11, 2021	Aug 11, 2021	1 AOP 413: Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure
726	733: Increase, Necrosis (terminal bronchiolar cells)	734: Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 109: Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)
1344	1264: Increase, E75b expression	1265: Decrease, Ftz-f1 expression	Feb 9, 2017	Feb 9, 2017	1 AOP 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1
2104	1775: Increase, Oocyte apoptosis	1366: Decrease, Oogenesis	Apr 30, 2020	Apr 30, 2020	5 AOPs 336: DNA methyltransferase inhibition leading to population decline (1) 338: DNA methyltransferase inhibition leading to population decline (3) 238: Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis 396: Deposition of ionizing energy leads to population decline via impaired meiosis 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis
2386	1775: Increase, Oocyte apoptosis	406: decreased, Fertility	May 12, 2021	May 12, 2021	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
2400	1775: Increase, Oocyte apoptosis	1696: Decrease of egg production and cummulative fecundity	May 18, 2021	May 18, 2021	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
2113	1780: Increase, Oocyte apoptosis (F3)	1782: Decrease, Oogenesis (F3)	Apr 30, 2020	Apr 30, 2020	1 AOP 340: DNA methyltransferase inhibition leading to transgenerational effects (1)
1747	1526: Increase, Opening of voltage-dependent calcium channel	1523: Decrease, Cuticular chitin content	May 24, 2018	May 24, 2018	1 AOP 361: Sulfonylureareceptor binding leading to mortality
2107	1777: Increase, Ovarian follicle breakdown	1366: Decrease, Oogenesis	Apr 30, 2020	Apr 30, 2020	1 AOP 337: DNA methyltransferase inhibition leading to population decline (2)
2560	1777: Increase, Ovarian follicle breakdown	328: Decrease, Fecundity	Feb 4, 2022	Feb 4, 2022	None
2118	1784: Increase, Ovarian follicle breakdown (F3)	1782: Decrease, Oogenesis (F3)	Apr 30, 2020	Apr 30, 2020	1 AOP 341: DNA methyltransferase inhibition leading to transgenerational effects (2)
2106	1776: Increase, Ovarian somatic cell apoptosis	1777: Increase, Ovarian follicle breakdown	Apr 30, 2020	Apr 30, 2020	1 AOP 337: DNA methyltransferase inhibition leading to population decline (2)
2117	1783: Increase, Ovarian somatic cell apoptosis (F3)	1784: Increase, Ovarian follicle breakdown (F3)	Apr 30, 2020	Apr 30, 2020	1 AOP 341: DNA methyltransferase inhibition leading to transgenerational effects (2)
1909	1634: Increase, Oxidative DNA damage	155: Inadequate DNA repair	May 19, 2019	Mar 8, 2024	3 AOPs 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 478: Deposition of energy leading to occurrence of cataracts 602: Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage
1913	1634: Increase, Oxidative DNA damage	1635: Increase, DNA strand breaks	May 19, 2019	Dec 17, 2024	2 AOPs 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 478: Deposition of energy leading to occurrence of cataracts
1914	1634: Increase, Oxidative DNA damage	185: Increase, Mutations	May 19, 2019	Jan 9, 2023	1 AOP 296: Oxidative DNA damage leading to chromosomal aberrations and mutations
2591	1634: Increase, Oxidative DNA damage	1444: Increase, Follicular atresia	Mar 1, 2022	Mar 1, 2022	1 AOP 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia
2592	1634: Increase, Oxidative DNA damage	1775: Increase, Oocyte apoptosis	Mar 1, 2022	Mar 1, 2022	1 AOP 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis
3230	1634: Increase, Oxidative DNA damage	1461: Increase, DSB	May 27, 2024	May 27, 2024	1 AOP 330: Excessive reactive oxygen species production leading to mortality (4)
3232	1634: Increase, Oxidative DNA damage	1365: Increase, Apoptosis	May 27, 2024	May 27, 2024	None
3359	1634: Increase, Oxidative DNA damage	55: Cell injury/death	Oct 8, 2024	Oct 8, 2024	None
3362	1634: Increase, Oxidative DNA damage	1505: Cell cycle, disrupted	Oct 8, 2024	Oct 8, 2024	None
3570	1634: Increase, Oxidative DNA damage	1262: Apoptosis	Aug 13, 2025	Aug 13, 2025	None
763	769: Increase, Oxidative metabolism	209: Peptide Oxidation	Nov 29, 2016	Dec 3, 2016	1 AOP 108: Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat)
1513	1392: Increase, Oxidative Stress	1393: Hepatocytotoxicity	May 30, 2017	Jun 19, 2021	1 AOP 220: Cyp2E1 Activation Leading to Liver Cancer

Key Event Relationships (KERs)

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