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Showing 3026 to 3050 of 3164 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1772	1222: SP (Substance P) release, Local increase of SP	1226: Respiratory irritability	Sep 24, 2018	Sep 24, 2018	1 AOP 196: Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
1734	1515: Spermatocyte depletion	1506: Testicular atrophy	May 22, 2018	Jul 28, 2021	1 AOP 212: Histone deacetylase inhibition leading to testicular atrophy
1024	1000: stabilization, PPAR alpha co-repressor	858: Decreased, PPARalpha transactivation of gene expression	Nov 29, 2016	Jun 11, 2018	1 AOP 6: Antagonist binding to PPARα leading to body-weight loss
2141	1788: Status epilepticus	388: Overactivation, NMDARs	May 21, 2020	May 21, 2020	None
2782	1788: Status epilepticus	1350: Increased, glutamate	Oct 12, 2022	Sep 3, 2023	1 AOP 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration
2783	1788: Status epilepticus	389: Increased, Intracellular Calcium overload	Oct 12, 2022	Jul 24, 2023	1 AOP 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration
2017	1706: Stimulation of TLR7/8	1707: Increase of IL-23	Dec 27, 2019	Dec 27, 2019	1 AOP 313: Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease
3207	2226: Binding PPAR isoforms	2224: Dysregulation of transcriptional expression within PPAR signaling network	May 8, 2024	May 8, 2024	None
3208	2226: Binding PPAR isoforms	179: Decrease, Fatty acid β-oxidation	May 8, 2024	May 8, 2024	None
3220	2226: Binding PPAR isoforms	2227: Disrupted PPAR isoform nuclear signaling	May 14, 2024	May 23, 2024	1 AOP 529: Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis
3399	2279: Structural changes in lamin A/C	2066: Altered Signaling	Nov 20, 2024	Nov 20, 2024	1 AOP 550: Increased LMNA gene mutation leading to heart failure
1968	1671: Substance - LS interaction	1672: Inhibition of LS function.	Jul 3, 2019	Jul 3, 2019	None
1702	1495: Interaction with the lung cell membrane	1496: Increased proinflammatory mediators	Jan 5, 2018	Jun 22, 2026	3 AOPs 173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis 451: Interaction with lung resident cell membrane components leads to lung cancer 237: Substance interaction with lung resident cell membrane components leading to atherosclerosis via acute phase response
2662	1495: Interaction with the lung cell membrane	1115: Increase, ROS	May 25, 2022	May 25, 2022	1 AOP 451: Interaction with lung resident cell membrane components leads to lung cancer
2663	1495: Interaction with the lung cell membrane	1669: Increased, DNA damage and mutation	May 25, 2022	May 25, 2022	1 AOP 451: Interaction with lung resident cell membrane components leads to lung cancer
2958	1495: Interaction with the lung cell membrane	1438: Increased transcription of genes encoding acute phase proteins	Jul 4, 2023	Jan 20, 2025	1 AOP 237: Substance interaction with lung resident cell membrane components leading to atherosclerosis via acute phase response
2959	1495: Interaction with the lung cell membrane	1439: Systemic acute phase response	Jul 4, 2023	Jan 20, 2025	1 AOP 237: Substance interaction with lung resident cell membrane components leading to atherosclerosis via acute phase response
2960	1495: Interaction with the lung cell membrane	1443: Atherosclerosis	Jul 4, 2023	Feb 19, 2025	1 AOP 237: Substance interaction with lung resident cell membrane components leading to atherosclerosis via acute phase response
3303	2243: Succinate Accumulation	1619: Increase, DNMT inhibition	Jul 18, 2024	Jul 18, 2024	1 AOP 474: Succinate dehydrogenase inactivation leads to cancer by promoting EMT
3304	2243: Succinate Accumulation	798: Inhibition, Prolyl hydroxylases	Jul 18, 2024	Jul 18, 2024	1 AOP 546: Succinate dehydrogenase inactivation leads to cancer through hypoxic-like mechanisms
2866	2118: SDH, inhibited	2120: Superoxide generation, increased	Apr 3, 2023	May 4, 2023	1 AOP 457: Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine
3233	2118: SDH, inhibited	1446: Decrease, Coupling of OXPHOS	May 28, 2024	May 28, 2024	1 AOP 534: Succinate dehydrogenase (SDH) inhibition leads to oxidative stress
3302	2118: SDH, inhibited	2243: Succinate Accumulation	Jul 18, 2024	Jul 18, 2024	2 AOPs 474: Succinate dehydrogenase inactivation leads to cancer by promoting EMT 546: Succinate dehydrogenase inactivation leads to cancer through hypoxic-like mechanisms
3554	2118: SDH, inhibited	177: Increase, Mitochondrial dysfunction	Aug 1, 2025	Aug 1, 2025	1 AOP 588: Inhibition of the mitochondrial complex II of nigro-striatal neurons leads to parkinsonian motor deficits
3273	2120: Superoxide generation, increased	1392: Increase, Oxidative Stress	Jul 4, 2024	Jul 4, 2024	1 AOP 457: Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine

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