AOPs

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Showing 301 to 325 of 579 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
328 Excessive reactive oxygen species production leading to mortality (2) You Song BY-SA 1115: Increase, Reactive oxygen species 350: Increase, Mortality
327 Excessive reactive oxygen species production leading to mortality (1) You Song BY-SA 1115: Increase, Reactive oxygen species 350: Increase, Mortality
326 Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and reduced cell proliferation You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
325 Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and reduced cell growth You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
324 Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and cell death You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
323 PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone Jennifer Olker BY-SA 227: Activation, PPARα
322 Alkylation of DNA leading to reduced sperm count Carole Yauk BY-SA 97: Alkylation, DNA 1757: Reduce, Sperm count
321 Reduced environmental pH leading to thinner shells in Mytilus edulis James Ducker BY-SA None None
320 Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality Young Jun Kim BY-SA 1739: Binding to ACE2 351: Increased Mortality Under Development 1.96
319 Binding to ACE2 leading to lung fibrosis Young Jun Kim BY-SA 1740: Induced dysregulation of ACE2 1276: Lung fibrosis Under Development 1.96
318 Glucocorticoid Receptor activation leading to hepatic steatosis Chander K. Negi BY-SA 122: Increase, Glucocorticoid receptor activation 459: Increase, Liver steatosis
316 Trypsin inhibition leading to pancreatic acinar cell tumors Shigeru Hisada BY-SA 1720: Trypsin inhibition 1725: Pancreatic acinar cell tumors Under Development 1.60
315 Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response Yasuhiro Yoshida BY-SA 1715: Inhibition of JAK3 1719: Impairment of T-cell dependent antibody response Under Development 1.74
314 Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE) Yasuharu Otsubo BY-SA 1710: Binding to estrogen receptor (ER)-α in immune cells 1714: Exacerbation of systemic lupus erythematosus (SLE) Under Development 1.73
313 Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease Hiroyuki Komatsu BY-SA 1706: Stimulation, TLR7/8 1709: Psoriatic skin disease Under Development 1.75
312 Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement​ Kristie Sullivan BY-SA 12: Acetylcholinesterase (AchE) Inhibition
311 Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis You Song BY-SA 1686: Deposition of Energy
310 Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR Jon Doering BY-SA 18: Activation, AhR
309 Luteinizing hormone receptor antagonism leading to reproductive dysfunction Young Jun Kim BY-SA 1691: Antagonism,LH receptor 679: Decline, Population trajectory
307 Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen BY-SA None 1688: anogenital distance (AGD), decreased Under Review 1.90
306 Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen BY-SA 26: Antagonism, Androgen receptor 1688: anogenital distance (AGD), decreased Under Review 1.90
305 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen BY-SA 1617: Inhibition, 5α-reductase 1688: anogenital distance (AGD), decreased Under Review 1.90
304 TBX1 inhibition leading to congenital cardiac conotruncal anomalies Jinsoo Lee All rights reserved 1680: Inhibition, TBX1 1685: Anomalies, Congenital cardiac conotruncal
303 Frustrated phagocytosis-induced lung cancer Carole Seidel BY-SA 1668: Frustrated phagocytosis 1670: Lung cancer Under Development 1.86
302 Lung surfactant function inhibition leading to decreased lung function Jorid Birkelund Sørli BY-SA 1672: Inhibition of lung surfactant function 1250: Decrease, Lung function Under Development 1.87