AOPs

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Showing 376 to 400 of 595 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
267 Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion You Song BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
266 Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity You Song BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
265 Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium You Song BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
264 Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death You Song BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
263 Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation You Song BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth WPHA/WNT Endorsed 1.92
262 L-type calcium channel blockade leading to the disruption of cardiac electrophysiology Luigi Margiotta-Casaluci BY-SA None None Under Development 1.45
261 L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility Luigi Margiotta-Casaluci BY-SA 1529: Blockade, L-Type Calcium Channels 1535: Heart failure Under Development 1.45
260 CYP2E1 activation and formation of protein adducts leading to neurodegeneration Jelle Broeders BY-SA 1514: Neurodegeneration
259 Sensitization induction of the intestinal tract by food proteins Erwin L Roggen BY-SA None None
258 Renal protein alkylation leading to kidney toxicity Angela Mally BY-SA 244: Alkylation, Protein 814: Occurrence, Kidney toxicity Under Development 1.43
257 Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity Angela Mally BY-SA 1486: Binding of substrate, endocytic receptor 814: Occurrence, Kidney toxicity Under Development 1.43
256 Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity Angela Mally BY-SA 1481: Inhibition of mitochondrial DNA polymerase gamma (Pol gamma) 814: Occurrence, Kidney toxicity Under Development 1.43
245 Reduction in photophosphorylation leading to growth inhibition in aquatic plants Knut Erik Tollefsen BY-SA 1471: Increase, Uncoupling of photophosphorylation 1521: Decrease, Growth
242 Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity Stefan Scholz Open for adoption 1462: Thiol group of chemicals interact with sulfuhydryl groups of proteins to form thiol adducts
241 Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis Marvin Martens BY-SA 1468: Activation, Latent Transforming Growth Factor Beta 1 1458: Pulmonary fibrosis
240 DNA Adducts Leading to Liver Hemangiosarcoma Undefined BY-SA None None
239 Oxidative Stress Leading to ILC2-mediated Respiratory Epithelial Remodeling Undefined BY-SA None None
238 Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis Knut Erik Tollefsen BY-SA 1686: Deposition of Energy
237 Substance interaction with lung resident cell membrane components leading to atherosclerosis via acute phase response Ulla Vogel BY-SA 1495: Substance interaction with the lung resident cell membrane components 1443: Atherosclerosis Under Development 1.55
236 Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition Timothy Allen BY-SA 1431: Serotonin 1A Receptor Agonism 1432: Anti-depressant Activity
235 Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening Timothy Allen BY-SA 1431: Serotonin 1A Receptor Agonism 1432: Anti-depressant Activity
234 Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition Timothy Allen BY-SA 1425: Mu Opioid Receptor Agonism 1428: Analgesia
233 Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening Timothy Allen BY-SA 1425: Mu Opioid Receptor Agonism 1428: Analgesia
232 NFE2/Nrf2 repression to steatosis Lyle Burgoon Open for adoption 1417: NFE2/Nrf2 repression 459: Increase, Liver steatosis
231 presynaptic neuron 2 repression to epilepsy Lyle Burgoon Open for adoption 1413: Reduced, presynaptic neuron 2 activity 1363: Increased, epilepsy