AOP-Wiki

API

All Key Events

Showing 1201 to 1225 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1663	Increased brain Homocysteine level Short Name brain Homocysteine level increases	0	Organ	Jun 14, 2019	Jun 14, 2019	None
1664	Induce Neuronal dysfunctions Short Name Neuronal dysfunctions induction	0	Individual	Jun 14, 2019	Jun 14, 2019	None
1665	Increased, Plasma HCY level Short Name Plasma HCY level	0	Tissue	Jul 3, 2019	Jul 3, 2019	301: Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis
1666	Induced, dysfunction of microcirculation Short Name dysfunction of microcirculation	0	Organ	Jul 3, 2019	Jul 3, 2019	2 AOPs 301: Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis 426: SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction.
1667	Impaired,anterior-posterior axis development Short Name anterior-posterior axis development	0	Individual	Jul 3, 2019	Jul 3, 2019	301: Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis
1668	Frustrated phagocytosis Short Name Frustrated phagocytosis	1	Cellular	Jul 3, 2019	Sep 16, 2022	2 AOPs 303: Frustrated phagocytosis-induced lung cancer 409: Frustrated phagocytosis leads to malignant mesothelioma
1669	Increased, DNA damage and mutation Short Name Increased, DNA damage and mutation	5	Cellular	Jul 3, 2019	Aug 13, 2019	6 AOPs 303: Frustrated phagocytosis-induced lung cancer 409: Frustrated phagocytosis leads to malignant mesothelioma 416: Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway 417: Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway 443: DNA damage and mutations leading to Metastatic Breast Cancer 451: Interaction with lung resident cell membrane components leads to lung cancer
1670	Lung cancer Short Name Lung cancer	2	Organ	Jul 3, 2019	Aug 13, 2019	5 AOPs 303: Frustrated phagocytosis-induced lung cancer 416: Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway 417: Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway 420: Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway 451: Interaction with lung resident cell membrane components leads to lung cancer
1671	Substance - lung surfactant interaction Short Name Substance - LS interaction	0	Molecular	Jul 3, 2019	Jul 3, 2019	None
1672	Inhibition of lung surfactant function Short Name Inhibition of LS function.	0	Molecular	Jul 3, 2019	Oct 27, 2021	302: Lung surfactant function inhibition leading to decreased lung function
1673	Alveolar collapse Short Name Alveolar collapse	0	Cellular	Jul 3, 2019	Oct 27, 2021	302: Lung surfactant function inhibition leading to decreased lung function
1674	Alveolar reopening Short Name Alveolar reopening	0	Tissue	Jul 3, 2019	Jul 3, 2019	None
1675	Loss of barrier function Short Name Loss of barrier function	0	Tissue	Jul 3, 2019	Jul 3, 2019	None
1676	Blood extravasation into the lungs Short Name Blood extravasation into the lungs	0	Organ	Jul 3, 2019	Jul 3, 2019	None
1677	Reduced tidal volume Short Name Reduced tidal volume	0	Organ	Jul 3, 2019	Feb 16, 2021	302: Lung surfactant function inhibition leading to decreased lung function
1678	Impaired oxygenation of the blood Short Name Impaired oxygenation of the blood	0	Organ	Jul 3, 2019	Jul 3, 2019	None
1679	Acute inhalation toxicity Short Name Acute inhalation toxicity	0	Individual	Jul 3, 2019	Jul 3, 2019	None
1680	Inhibition, TBX1 Short Name Inhibition, TBX1	0	Molecular	Aug 13, 2019	Aug 13, 2019	304: TBX1 inhibition leading to congenital cardiac conotruncal anomalies
1681	Disruption, Neural crest cell migration Short Name Disruption, Neural crest cell migration	0	Cellular	Aug 13, 2019	Aug 13, 2019	304: TBX1 inhibition leading to congenital cardiac conotruncal anomalies
1682	Disruption, Progenitor cells of second heart field Short Name	0	Cellular	Aug 13, 2019	Feb 15, 2022	2 AOPs 304: TBX1 inhibition leading to congenital cardiac conotruncal anomalies 436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
1683	Impairment, Fourth pharyngeal arch development Short Name	0	Tissue	Aug 13, 2019	Aug 13, 2019	304: TBX1 inhibition leading to congenital cardiac conotruncal anomalies
1684	Abnormalities, Cardiac outflow tract formation Short Name	0	Organ	Aug 13, 2019	Aug 13, 2019	304: TBX1 inhibition leading to congenital cardiac conotruncal anomalies
1685	Anomalies, Congenital cardiac conotruncal Short Name	0	Individual	Aug 13, 2019	Aug 13, 2019	304: TBX1 inhibition leading to congenital cardiac conotruncal anomalies
1686	Deposition of Energy Short Name Energy Deposition	1	Molecular	Aug 22, 2019	Aug 23, 2024	17 AOPs 272: Deposition of energy leading to lung cancer 432: Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction 388: Deposition of ionising energy leading to population decline via programmed cell death 435: Deposition of ionising energy leads to population decline via pollen abnormal 216: Deposition of energy leading to population decline via DNA strand breaks and follicular atresia 238: Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia 441: Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability 470: Deposition of energy leads to abnormal vascular remodeling 473: Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin 478: Deposition of energy leading to occurrence of cataracts 482: Deposition of energy leading to occurrence of bone loss 483: Deposition of Energy Leading to Learning and Memory Impairment
1688	anogenital distance (AGD), decreased Short Name AGD, decreased	1	Tissue	Aug 30, 2019	Dec 22, 2022	4 AOPs 305: 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring 306: Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring 476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity