API

Relationship: 1490

Title

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Altered, Cardiovascular development/function leads to Increased, Mortality

Upstream event

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Altered, Cardiovascular development/function

Downstream event

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Increased, Mortality

Key Event Relationship Overview

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AOPs Referencing Relationship

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AOP Name Adjacency Weight of Evidence Quantitative Understanding
AhR activation leading to early life stage mortality adjacent High Moderate

Taxonomic Applicability

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Term Scientific Term Evidence Link
Atlantic killifish Fundulus heteroclitus Moderate NCBI
zebrafish Danio rerio High NCBI
rainbow trout Oncorhynchus mykiss Moderate NCBI
medaka Oryzias latipes High NCBI
fathead minnow Pimephales promelas Moderate NCBI
channel catfish Ictalurus punctatus Moderate NCBI
Salvelinus namaycush Salvelinus namaycush Moderate NCBI
Salvelinus fontinalis Salvelinus fontinalis Moderate NCBI
Carassius carassius Carassius carassius Moderate NCBI
Pagrus major Pagrus major Moderate NCBI
Acipenser fulvescens Acipenser fulvescens Moderate NCBI
Coregonus artedi Coregonus artedi Moderate NCBI
Catostomus commersoni Catostomus commersonii Moderate NCBI
Esox lucius Esox lucius Moderate NCBI
Scaphirhynchus albus Scaphirhynchus albus Moderate NCBI
Scaphirhynchus platorynchus Scaphirhynchus platorynchus Moderate NCBI
Gallus gallus Gallus gallus High NCBI

Sex Applicability

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Sex Evidence
Unspecific High

Life Stage Applicability

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Term Evidence
Embryo High
Development High

Key Event Relationship Description

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Evidence Supporting this KER

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Biological Plausibility

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Empirical Evidence

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Uncertainties and Inconsistencies

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Quantitative Understanding of the Linkage

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Response-response Relationship

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Time-scale

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Known modulating factors

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Known Feedforward/Feedback loops influencing this KER

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Domain of Applicability

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References

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