This Key Event Relationship is licensed under the Creative Commons BY-SA license. This license allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use. If you remix, adapt, or build upon the material, you must license the modified material under identical terms.
Increase, Mitochondrial complex III antagonism leads to Increased reactive oxygen species (in the mitochondria)
Key Event Relationship Overview
AOPs Referencing Relationship
Life Stage Applicability
Key Event Relationship Description
Perturbation of one of the complexes in the oxidative phosphorylation will lead to disturbed electron flow and therefore more available electron that can create oxygen radicals.
Threshold relationship = When the radical formation reaches a certain threshold the antioxidant system cannot cope with the inflow of radicals leading to accumulation of radicals in the mitochondria. One of the important antioxidants involved in the ROS removal is MnSOD.
Evidence Collection Strategy
Evidence Supporting this KER
It has been well established that complex inhibition leads to ROS production.
Mitochondrial complexes possess multiple sites that can produce these superoxides.