API

Relationship: 381

Title

?

Induction, Upregulation of glucuronyltransferase activity leads to Decrease, Serum thyroxine (T4)

Upstream event

?

Induction, Upregulation of glucuronyltransferase activity

Downstream event

?


Decrease, Serum thyroxine (T4)

Key Event Relationship Overview

?


AOPs Referencing Relationship

?

AOP Name Directness Weight of Evidence Quantitative Understanding
Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals indirectly leads to Strong Weak

Taxonomic Applicability

?


Sex Applicability

?


Life Stage Applicability

?


How Does This Key Event Relationship Work

?


Weight of Evidence

?


Biological Plausibility

?

Empirical Support for Linkage

?

Uncertainties or Inconsistencies

?

Quantitative Understanding of the Linkage

?


Evidence Supporting Taxonomic Applicability

?


References

?