Key Event Relationships (KERs)

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Showing 2476 to 2500 of 3081 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
2495 1931: Disruption of the intestinal barrier 1868: Hyperinflammation Oct 19, 2021 Feb 8, 2023 None
3335 1931: Disruption of the intestinal barrier 2257: Celiac disease Aug 13, 2024 Feb 27, 2025
3564 2339: Intracellular copper, increased 1632: Increase in RONS Aug 13, 2025 Aug 13, 2025 None
3571 2339: Intracellular copper, increased 2340: Oligomerisation of DLAT, increased Aug 13, 2025 Aug 13, 2025
3574 2339: Intracellular copper, increased 2342: Fe-S cluster assembly, impaired Aug 13, 2025 Aug 13, 2025
3575 2342: Fe-S cluster assembly, impaired 1477: OXPHOS, decreased Aug 13, 2025 Aug 13, 2025 None
3578 2342: Fe-S cluster assembly, impaired 889: Proteostasis, impaired Aug 13, 2025 Aug 13, 2025
3580 2342: Fe-S cluster assembly, impaired 2341: TCA cycle, disrupted Aug 13, 2025 Aug 13, 2025
3709 2342: Fe-S cluster assembly, impaired 178: Mitochondrial electron transport chain, disrupted Jan 7, 2026 Jan 7, 2026
1167 1134: Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle 1131: Failure in gamma-glutamyl carboxylation of clotting factors II, VII, IX and X, Under carbo Nov 29, 2016 Dec 3, 2016
1774 1434: Irritation induced sneezing 1223: Increased Airway Hyper-responsiveness,Cough, Dyspnea Sep 24, 2018 Sep 24, 2018 None
955 927: S-Glutathionylation, eNOS 932: Uncoupling, eNOS Nov 29, 2016 Oct 12, 2017
3692 2389: Altered steroidogenesis 2390: reproductive hormonal Imbalance Nov 7, 2025 Nov 7, 2025
952 935: Decrease, GTPCH-1 934: Decrease, Tetrahydrobiopterin Nov 29, 2016 Oct 12, 2017
953 934: Decrease, Tetrahydrobiopterin 932: Uncoupling, eNOS Nov 29, 2016 Oct 12, 2017
956 932: Uncoupling, eNOS 933: Depletion, Nitric Oxide Nov 29, 2016 Oct 12, 2017
3014 932: Uncoupling, eNOS 2161: Increase, Vascular disrupting effects Aug 21, 2023 Aug 21, 2023 None
3023 932: Uncoupling, eNOS 1928: increased，Vascular endothelial dysfunction Aug 21, 2023 Aug 21, 2023
988 973: Decrease, AKT/eNOS activity 933: Depletion, Nitric Oxide Nov 29, 2016 Oct 16, 2017
3694 2390: reproductive hormonal Imbalance 2391: Reduced fertility Nov 7, 2025 Nov 7, 2025
958 933: Depletion, Nitric Oxide 937: Impaired, Vasodilation Nov 29, 2016 Oct 12, 2017
982 937: Impaired, Vasodilation 951: Increase, Vascular Resistance Nov 29, 2016 Oct 13, 2017
983 951: Increase, Vascular Resistance 952: Hypertension Nov 29, 2016 Oct 13, 2017
2152 1795: TGFbeta expression 1283: Activation, TGF-beta pathway Jul 9, 2020 Jul 9, 2020
1778 1494: Leukocyte recruitment/activation 265: Increase, HSC activation Nov 12, 2018 Nov 12, 2018