AOPs

OECD View API
Searches both title and fulltext content
Takes you to the requested AOP
Clear Search Terms Clears search terms and filters

Showing 101 to 125 of 574 AOPs

Clear Table Filters
ID Title Point of Contact License MIE AO OECD Status OECD Project
120 Inhibition of 5α-reductase leading to Leydig cell tumors (in rat) Charles Wood BY-SA 1617: Inhibition, 5α-reductase 745: Increase, Leydig cell tumors
121 Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat) Charles Wood BY-SA 793: Increase, Urinary bladder calculi 797: Increase, Adenomas/carcinomas (urothelial)
122 Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation Dalma Martinovic-Weigelt BY-SA 798: Inhibition, Prolyl hydroxylases
123 Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription Dalma Martinovic-Weigelt BY-SA 801: modulation, Unknown
124 HMG-CoA reductase inhibition leading to decreased fertility Kellie Fay BY-SA 804: Inhibition, HMG-CoA reductase 330: Decrease, Fertility
126 Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation Undefined BY-SA 849: Inhibition, Antgonism of NE receptor 527: Decreased, Decreased fecundity
128 Kidney dysfunction by decreased thyroid hormone Jung-Hwa Oh BY-SA 277: Thyroid hormone synthesis, Decreased 814: Occurrence, Kidney toxicity Under Development 1.40
130 Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity Jung-Hwa Oh BY-SA 828: Inhibition, Phospholipase A 840: Formation, Liver fibrosis Under Development 1.39
131 Aryl hydrocarbon receptor activation leading to uroporphyria Amani Farhat BY-SA 18: Activation, AhR 369: Uroporphyria WPHA/WNT Endorsed 1.7
134 Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Mary Gilbert BY-SA 424: Inhibition, Na+/I- symporter (NIS) 402: Cognitive function, decreased
136 Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors Undefined BY-SA 867: Decrease, Intracellular pH 872: Increase, Site of Contact Nasal Tumors Under Review 2.7
138 Organic anion transporter (OAT1) inhibition leading to renal failure and mortality Kellie Fay BY-SA 877: Inhibition, organic anion transporter 1 (OAT1)
139 Alkylation of DNA leading to cancer 1 Carole Yauk Open for adoption 97: Alkylation, DNA 885: Increase, Cancer
144 Endocytic lysosomal uptake leading to liver fibrosis Marina Kuburic BY-SA 1539: Endocytotic lysosomal uptake 344: Increase, Liver fibrosis Under Review 1.47
146 Estrogen Receptor Activation and Female Precocious Puberty Undefined Open for adoption None None
148 EGFR Activation Leading to Decreased Lung Function Karsta Luettich BY-SA 941: Activation, EGFR 1250: Decrease, Lung function Under Development 1.51
149 Peptide Oxidation Leading to Hypertension Frazer Lowe BY-SA 209: Peptide Oxidation 952: Hypertension Under Development 1.50
150 Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF Amani Farhat BY-SA 18: Activation, AhR 947: Increase, Early Life Stage Mortality WPHA/WNT Endorsed 1.7
151 AhR activation leading to preeclampsia Sabrina Tait All rights reserved 18: Activation, AhR 1893: increase, Preeclampsia Under Development 1.42
152 Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity Kristie Sullivan BY-SA 957: Binding, Transthyretin in serum 402: Cognitive function, decreased Under Development 1.41
153 Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats Undefined BY-SA 964: Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol 972: Decreased fertility, Reduced number of oocytes ovulated
154 Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response Takumi Ohishi BY-SA 980: Inhibition, Calcineurin Activity 984: Impairment, T-cell dependent antibody response WPHA/WNT Endorsed 1.38
155 Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation Dries Knapen BY-SA 1002: Inhibition, Deiodinase 2 WPHA/WNT Endorsed 1.35
156 Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation Dries Knapen BY-SA 1002: Inhibition, Deiodinase 2 WPHA/WNT Endorsed 1.35
157 Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation Dries Knapen BY-SA 1009: Inhibition, Deiodinase 1 WPHA/WNT Endorsed 1.35