AOP-Wiki

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All Key Events

Showing 126 to 150 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

289	Decrease, Translocator protein (TSPO) Short Name Decrease, Translocator protein (TSPO)	1	Cellular	Nov 29, 2016	Sep 16, 2017	18: PPARα activation in utero leading to impaired fertility in males
291	Accumulation, Triglyceride Short Name Accumulation, Triglyceride	1	Cellular	Nov 29, 2016	Mar 26, 2024	8 AOPs 34: LXR activation leading to hepatic steatosis 57: AhR activation leading to hepatic steatosis 318: Glucocorticoid Receptor activation leading to hepatic steatosis 517: Pregnane X Receptor (PXR) activation leads to liver steatosis 518: Liver X Receptor (LXR) activation leads to liver steatosis 529: Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis 580: Mineralocorticoid Receptor Activation Leading to Increased Body Mass Index 591: DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration
294	N/A, Unknown Short Name N/A, Unknown	0	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 33: Kidney toxicity induced by activation of 5HT2C 1: Uncharacterized liver damage leading to hepatocellular carcinoma
295	Induction, Upregulation of glucuronyltransferase activity Short Name	2	Molecular	Nov 29, 2016	Sep 16, 2017	4 AOPs 8: Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 194: Hepatic nuclear receptor activation leading to altered amphibian metamorphosis 162: Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
298	Insufficiency, Vascular Short Name Insufficiency, Vascular	2	Molecular	Nov 29, 2016	Jul 20, 2022	43: Disruption of VEGFR Signaling Leading to Developmental Defects
301	Binding, VEGF-A Short Name Binding, VEGF-A	0		Nov 29, 2016	Nov 29, 2016	None
302	Production, VEGF-A Short Name Production, VEGF-A	0		Nov 29, 2016	Nov 29, 2016	None
304	Decreased, VegfR2 Short Name Decreased, VegfR2	0		Nov 29, 2016	Nov 29, 2016	None
305	Inhibition, VegfR2 Short Name Inhibition, VegfR2	2	Molecular	Nov 29, 2016	Jan 17, 2022	43: Disruption of VEGFR Signaling Leading to Developmental Defects
307	Increase, Vitellogenin synthesis in liver Short Name	1	Tissue	Nov 29, 2016	Jun 24, 2024	3 AOPs 29: Estrogen receptor agonism leading to reproductive dysfunction 536: Estrogen receptor agonism leading to reduced survival and population growth due to renal failure 537: Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver
309	Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development Short Name	3	Cellular	Nov 29, 2016	Sep 16, 2017	9 AOPs 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 30: Estrogen receptor antagonism leading to reproductive dysfunction 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production 549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish
310	Alteration, Wnt pathway Short Name Alteration, Wnt pathway	1	Cellular	Nov 29, 2016	Sep 16, 2017	19: Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)
312	N/A, Allergic contact dermatitis on challenge Short Name	0	Individual	Nov 29, 2016	Nov 29, 2016	None
313	Increase, Allergic Respiratory Hypersensitivity Response Short Name	1	Organ	Nov 29, 2016	Feb 7, 2023	39: Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response
315	Decreased, Body length Short Name Decreased, Body length	0		Nov 29, 2016	Nov 29, 2016	None
317	Altered, Cardiovascular development/function Short Name	2	Organ	Nov 29, 2016	Sep 16, 2017	3 AOPs 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF 21: Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
319	Loss, Cochlear function Short Name Loss, Cochlear function	1	Organ	Nov 29, 2016	Sep 16, 2017	8: Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
320	Increase, Curved body axis Short Name Increase, Curved body axis	0		Nov 29, 2016	Nov 29, 2016	None
321	N/A, Cyanosis occurs Short Name N/A, Cyanosis occurs	1	Individual	Nov 29, 2016	Dec 3, 2016	31: Oxidation of iron in hemoglobin leading to hematotoxicity
323	Increased, Disease susceptibility Short Name Increased, Disease susceptibility	1	Individual	Nov 29, 2016	Dec 3, 2016	14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
327	Accumulation, Fatty acid Short Name Accumulation, Fatty acid	1	Organ	Nov 29, 2016	Sep 16, 2017	5 AOPs 36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis 57: AhR activation leading to hepatic steatosis 58: NR1I3 (CAR) suppression leading to hepatic steatosis 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis 529: Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis
328	Decrease, Fecundity Short Name Decrease, Fecundity	0	Individual	Nov 29, 2016	Jun 12, 2018	5 AOPs 336: DNA methyltransferase inhibition leading to population decline (1) 337: DNA methyltransferase inhibition leading to population decline (2) 338: DNA methyltransferase inhibition leading to population decline (3) 339: DNA methyltransferase inhibition leading to population decline (4) 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
330	Decrease, Fertility Short Name Decrease, Fertility	1	Individual	Nov 29, 2016	Jun 29, 2017	124: HMG-CoA reductase inhibition leading to decreased fertility
334	Promotion, Hepatocelluar carcinoma Short Name Promotion, Hepatocelluar carcinoma	1	Individual	Nov 29, 2016	Sep 16, 2017	1: Uncharacterized liver damage leading to hepatocellular carcinoma
336	Increase, Heritable mutations in offspring Short Name	1	Individual	Nov 29, 2016	Nov 29, 2016	15: Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations