AOP-Wiki

API

All Key Events

Showing 901 to 925 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1494	Leukocyte recruitment/activation Short Name Leukocyte recruitment/activation	1	Cellular	Nov 28, 2017	Dec 1, 2017	3 AOPs 144: Endocytic lysosomal uptake leading to liver fibrosis 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
1493	Increased Pro-inflammatory mediators Short Name Increased pro-inflammatory mediators	1	Tissue	Nov 28, 2017	Sep 17, 2024	8 AOPs 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 38: Protein Alkylation leading to Liver Fibrosis 144: Endocytic lysosomal uptake leading to liver fibrosis 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 432: Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia 470: Deposition of energy leads to abnormal vascular remodeling
1492	Tissue resident cell activation Short Name Tissue resident cell activation	1	Cellular	Nov 28, 2017	Nov 15, 2024	5 AOPs 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 38: Protein Alkylation leading to Liver Fibrosis 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 483: Deposition of Energy Leading to Learning and Memory Impairment
1491	Increased, Oncotic Necrosis Short Name increased, oncotic necrosis	0	Tissue	Nov 14, 2017	Nov 27, 2017	213: Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH)
1490	Inhibition, Fatty Acid Beta Oxidation Short Name Inhibition of fatty acid beta oxidation	0	Molecular	Nov 13, 2017	Nov 27, 2017	213: Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH)
1489	Increase, Steatohepatitis Short Name Increase, Steatohepatitis	0	Organ	Nov 13, 2017	Feb 24, 2026	9 AOPs 213: Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH) 401: G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress 642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
1488	Glutamate dyshomeostasis Short Name Glutamate dyshomeostasis	0	Cellular	Nov 9, 2017	Jul 15, 2022	17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
1487	Binding, Thiol/seleno-proteins involved in protection against oxidative stress Short Name	0	Molecular	Nov 9, 2017	Jul 15, 2022	2 AOPs 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 284: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease
1486	Binding of substrate, endocytic receptor Short Name	0	Molecular	Oct 25, 2017	Oct 25, 2017	257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
1485	Binding of substrate, endocytotic receptor Short Name	0	Molecular	Oct 25, 2017	Oct 25, 2017	None
1484	Receptor mediated endocytosis Short Name Receptor mediated endocytosis	0	Molecular	Oct 25, 2017	Oct 25, 2017	None
1482	Depletion, mtDNA Short Name Depletion, mtDNA	0	Cellular	Oct 25, 2017	Oct 25, 2017	256: Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity
1481	Inhibition of mitochondrial DNA polymerase gamma (Pol gamma) Short Name	0	Molecular	Oct 25, 2017	Oct 25, 2017	256: Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity
1480	Increase, Growth hormone Short Name Increase, Growth hormone	0	Organ	Oct 10, 2017	Feb 16, 2021	None
1479	Decrease, Leaf development Short Name Decrease, Leaf development	0	Organ	Oct 10, 2017	Oct 10, 2017	2 AOPs 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants 389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis
1478	Decrease, Leaf cell mitosis Short Name Decrease, Leaf cell mitosis	0	Tissue	Oct 10, 2017	Oct 10, 2017	245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants
1477	Oxidative phosphorylation, decreased Short Name OXPHOS, decreased	0	Cellular	Oct 10, 2017	Oct 16, 2025	4 AOPs 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants 276: Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome 328: Excessive reactive oxygen species production leading to mortality (2) 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction
1476	Decrease, Glycolysis Short Name Decrease, Glycolysis	0	Cellular	Oct 10, 2017	Oct 10, 2017	245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants
1475	Decrease, Photosynthesis Short Name Decrease, Photosynthesis	0	Cellular	Oct 10, 2017	Jan 20, 2026	4 AOPs 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis 567: Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition
1474	Decrease, Light harvest capacity Short Name Decrease, Light harvest capacity	0	Cellular	Oct 10, 2017	Oct 10, 2017	245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants
1473	Decrease, Chlorophyll synthesis Short Name Decrease, Chlorophyll synthesis	0	Cellular	Oct 10, 2017	Oct 10, 2017	245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants
1472	Decrease, ATP production Short Name Decrease, ATP production	1	Cellular	Oct 10, 2017	Feb 4, 2026	5 AOPs 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction 567: Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition
1471	Increase, Uncoupling of photophosphorylation Short Name	0	Cellular	Oct 10, 2017	Oct 10, 2017	245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants
1470	inherited mutations in offspring Short Name increase in inherited mutations	0	Individual	Aug 20, 2017	Aug 20, 2017	None
1469	Activation, Transforming Growth Factor beta pathway Short Name TGFbeta pathway activation	0	Molecular	Aug 16, 2017	Aug 16, 2017	241: Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis