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Showing 1501 to 1525 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1635	1461: Increase, DSB	1253: MLL translocation	Aug 2, 2017	Aug 1, 2022	1 AOP 202: Inhibitor binding to topoisomerase II leading to infant leukaemia
3096	1461: Increase, DSB	1365: Increase, Apoptosis	Nov 16, 2023	Nov 16, 2023	1 AOP 330: Excessive reactive oxygen species production leading to mortality (4)
3099	1461: Increase, DSB	1774: Increase, Casp transcription	Nov 16, 2023	Nov 16, 2023	1 AOP 338: DNA methyltransferase inhibition leading to population decline (3)
1884	1620: Increase, DNA hypomethylation	1621: Increase, Gene expression	Apr 22, 2019	Apr 22, 2019	None
1887	1620: Increase, DNA hypomethylation	1622: Decrease, Transgenerational DNA methylation	Apr 22, 2019	Apr 22, 2019	None
1993	1697: Increase, DNMT expression	1698: Increase, hypermethylation of the promotor region of GnRHR	Oct 30, 2019	Oct 30, 2019	1 AOP 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
1883	1619: Increase, DNMT inhibition	1620: Increase, DNA hypomethylation	Apr 22, 2019	Apr 22, 2019	None
2101	1619: Increase, DNMT inhibition	1773: Decrease, Global DNA methylation	Apr 30, 2020	Apr 30, 2020	4 AOPs 336: DNA methyltransferase inhibition leading to population decline (1) 337: DNA methyltransferase inhibition leading to population decline (2) 340: DNA methyltransferase inhibition leading to transgenerational effects (1) 341: DNA methyltransferase inhibition leading to transgenerational effects (2)
3098	1619: Increase, DNMT inhibition	1461: Increase, DSB	Nov 16, 2023	Nov 16, 2023	1 AOP 338: DNA methyltransferase inhibition leading to population decline (3)
3305	1619: Increase, DNMT inhibition	1457: EMT	Jul 18, 2024	Jul 18, 2024	1 AOP 474: Succinate dehydrogenase inactivation leads to cancer by promoting EMT
1911	1635: Increase, DNA strand breaks	155: Inadequate DNA repair	May 19, 2019	Mar 8, 2024	3 AOPs 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 272: Deposition of energy leading to lung cancer 478: Deposition of energy leading to occurrence of cataracts
1931	1635: Increase, DNA strand breaks	185: Increase, Mutations	Jun 2, 2019	Jan 9, 2023	2 AOPs 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 272: Deposition of energy leading to lung cancer
1939	1635: Increase, DNA strand breaks	1636: Increase, Chromosomal aberrations	Jun 3, 2019	Jan 9, 2023	2 AOPs 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 272: Deposition of energy leading to lung cancer
2074	1635: Increase, DNA strand breaks	1365: Increase, Apoptosis	Apr 6, 2020	Apr 6, 2020	1 AOP 322: Alkylation of DNA leading to reduced sperm count
2587	1635: Increase, DNA strand breaks	1444: Increase, Follicular atresia	Mar 1, 2022	Mar 1, 2022	1 AOP 216: Deposition of energy leading to population decline via DNA strand breaks and follicular atresia
2589	1635: Increase, DNA strand breaks	1775: Increase, Oocyte apoptosis	Mar 1, 2022	Mar 1, 2022	1 AOP 238: Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis
2841	1635: Increase, DNA strand breaks	2098: Abnormal Neural Remodeling	Jan 25, 2023	Jul 29, 2024	1 AOP 483: Deposition of Energy Leading to Learning and Memory Impairment
2856	1635: Increase, DNA strand breaks	2066: Altered Signaling	Mar 10, 2023	Mar 21, 2023	None
3315	1635: Increase, DNA strand breaks	2244: Altered Stress Response Signaling	Jul 24, 2024	Aug 26, 2024	2 AOPs 470: Deposition of energy leads to abnormal vascular remodeling 483: Deposition of Energy Leading to Learning and Memory Impairment
3480	1635: Increase, DNA strand breaks	1505: Cell cycle, disrupted	Jan 20, 2025	Jan 20, 2025	1 AOP 602: Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage
3593	1635: Increase, DNA strand breaks	1281: Increased, DNA Damage-Repair	Aug 16, 2025	Aug 16, 2025	1 AOP 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis
732	746: Increase, Dopaminergic activity	747: Decreased, Prolactin	Nov 29, 2016	Dec 3, 2016	1 AOP 112: Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat)
770	746: Increase, Dopaminergic activity	773: Increase, Endometrial adenocarcinomas	Nov 29, 2016	Dec 3, 2016	None
3672	746: Increase, Dopaminergic activity	602: Increased, Ataxia, paralysis, or hyperactivity	Oct 20, 2025	Oct 20, 2025	1 AOP 611: Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes
3642	2374: Increase, EcR antagonism	2375: Decrease, Mis-timed EcR-responsive NR cascade	Sep 29, 2025	Sep 29, 2025	2 AOPs 343: Ecdysone receptor antagonism leading to mortality via mis-timed ecdysone receptor-responsive nuclear receptor cascade 606: Ecdysone receptor antagonism leading to mortality via inhibition of chitin synthase 1

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