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Showing 1851 to 1875 of 3130 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2196	1818: Immune cell activation	1819: IFNγ signaling	Nov 2, 2020	Nov 2, 2020	1 AOP 362: Immune mediated hepatitis
2318	1856: Sodium inhibition, Sweet enhancement	1849: Impaired gustatory nerve	Apr 10, 2021	Apr 10, 2021	1 AOP 381: Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia
3784	2422: Decreased FGF15/FGF19	2424: Hepatic CYP7A1, increased	Apr 27, 2026	Apr 27, 2026	1 AOP 642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
2197	1819: IFNγ signaling	1633: Increase in inflammation	Nov 2, 2020	Nov 2, 2020	1 AOP 362: Immune mediated hepatitis
3191	2107: Hypomyelination	2108: Altered, white brain matter	Apr 12, 2024	Apr 12, 2024	1 AOP 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
1083	1043: Hypertrophy/hyperplasia, smooth muscle	1044: Promotion, mesovarian leiomyomas	Nov 29, 2016	Dec 3, 2016	1 AOP 164: Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse
755	763: hyperpolarisation, neuron	764: N/A, Ataxia, paralysis, or hyperactivity	Nov 29, 2016	Dec 3, 2016	1 AOP 113: Glutamate-gated chloride channel activation leading to acute mortality
1566	763: hyperpolarisation, neuron	1428: Analgesia	Jun 8, 2017	Jun 8, 2017	1 AOP 233: Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening
1572	763: hyperpolarisation, neuron	1432: Anti-depressant Activity	Jun 23, 2017	Jun 23, 2017	1 AOP 235: Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening
1094	1051: Hyperplasia, ovarian stromal cells	1054: Promotion, ovarian granular cell tumors	Nov 29, 2016	Dec 3, 2016	1 AOP 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
1093	1052: Hyperplasia, ovarian epithelium	1053: Promotion, ovarian adenomas	Nov 29, 2016	Dec 3, 2016	2 AOPs 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse 440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
1115	1078: Hyperplasia, Mammary gland	1080: Increased, latency period	Nov 29, 2016	Dec 3, 2016	1 AOP 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.
1116	1078: Hyperplasia, Mammary gland	1079: Increased, Adenomas/carcinomas (mammary)	Nov 29, 2016	Dec 3, 2016	1 AOP 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.
462	415: Hyperplasia, Leydig cell	406: decreased, Fertility	Nov 29, 2016	Dec 3, 2016	1 AOP 51: PPARα activation leading to impaired fertility in adult male rodents
158	142: Hyperplasia, Hyperplasia	334: Promotion, Hepatocelluar carcinoma	Nov 29, 2016	Dec 3, 2016	1 AOP 1: Uncharacterized liver damage leading to hepatocellular carcinoma
3429	2289: RyR2 hyperphosphorylation	389: Increased, Intracellular Calcium overload	Nov 22, 2024	Nov 22, 2024	1 AOP 558: Phosphodiesterase inhibition leading to heart failure
2762	1868: Hyperinflammation	1748: Increase, the risk of acute respiratory failure	Sep 1, 2022	Sep 1, 2022	None
2326	1853: Hyperactivation of ACE/Ang-II/AT1R axis	1752: Increased AngII	Apr 10, 2021	Apr 10, 2021	1 AOP 384: Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease
2521	1853: Hyperactivation of ACE/Ang-II/AT1R axis	1535: Heart failure	Oct 28, 2021	Oct 28, 2021	None
3328	2252: Formation of HLA-DQ2/8-gluten complexes	272: Activation/Proliferation, T-cells	Aug 13, 2024	Aug 13, 2024	None
3338	2252: Formation of HLA-DQ2/8-gluten complexes	2260: Activation of gluten-reactive CD4+ T cells	Sep 13, 2024	Sep 13, 2024	None
3383	2252: Formation of HLA-DQ2/8-gluten complexes	2275: Co-localization of gluten reactive adaptive T-cells with APC	Nov 12, 2024	Apr 8, 2025	1 AOP 524: Gluten-driven immune activation leading to celiac disease in genetically predisposed individuals
1709	1502: Histone deacetylase inhibition	1503: Histone acetylation, increase	Jan 21, 2018	Aug 5, 2021	2 AOPs 212: Histone deacetylase inhibition leading to testicular atrophy 275: Histone deacetylase inhibition leads to neural tube defects
1714	1502: Histone deacetylase inhibition	1504: p21 (CDKN1A) expression, increase	Jan 21, 2018	Jul 25, 2018	None
1715	1502: Histone deacetylase inhibition	1505: Cell cycle disruption	Jan 21, 2018	Jul 28, 2021	1 AOP 212: Histone deacetylase inhibition leading to testicular atrophy

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