AOPs

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Showing 551 to 575 of 588 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
48 Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. Anna Price BY-SA 875: Binding of agonist, Ionotropic glutamate receptors 341: Impairment, Learning and memory WPHA/WNT Endorsed 1.23
46 AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC) Ted Simon BY-SA 373: Formation, Pro-mutagenic DNA Adducts 378: Tumorigenesis, Hepatocellular carcinoma Under Review 1.8
43 Disruption of VEGFR Signaling Leading to Developmental Defects Undefined BY-SA 305: Inhibition, VegfR2 1001: Increased, Developmental Defects WPHA/WNT Endorsed 1.6
42 Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Kevin Crofton BY-SA 279: Thyroperoxidase, Inhibition 402: Cognitive function, decreased WPHA/WNT Endorsed 1.10
41 Sustained AhR Activation leading to Rodent Liver Tumours Undefined BY-SA 165: Activation, Long term AHR receptor driven direct and indirect gene expression changes 856: Formation, Hepatocellular and Bile duct tumors Under Review 1.7
40 Covalent Protein binding leading to Skin Sensitisation Undefined BY-SA 396: Covalent Binding, Protein 827: sensitisation, skin WPHA/WNT Endorsed 1.1
39 Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response Jessica Ponder BY-SA 396: Covalent Binding, Protein 313: Increase, Allergic Respiratory Hypersensitivity Response Under Development 1.20
38 Protein Alkylation leading to Liver Fibrosis Brigitte Landesmann BY-SA 244: Alkylation, Protein 344: Increase, Liver fibrosis WPHA/WNT Endorsed 1.14
37 PPARα activation leading to hepatocellular adenomas and carcinomas in rodents Chris Corton BY-SA 227: Activation, PPARα 719: Increase, hepatocellular adenomas and carcinomas Under Development 1.17
36 Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis Michelle Angrish BY-SA 459: Increase, Liver steatosis
35 Narcosis leading to respiratory failure Dries Knapen BY-SA 46: Accumulation, Biological membranes None Under Development 1.2
34 LXR activation leading to hepatic steatosis Undefined BY-SA 345: N/A, Liver Steatosis
33 Kidney toxicity induced by activation of 5HT2C Kevin Crofton Open for adoption 9: Activation, 5HT2c 759: Increased, Kidney Failure
32 Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors Undefined BY-SA None None
31 Oxidation of iron in hemoglobin leading to hematotoxicity Undefined Open for adoption 213: N/A, Parent compound is converted to the reactive metabolite and forms free radicals leading to oxidation of heme iron(II) in hemoglobin to iron(III) 321: N/A, Cyanosis occurs Under Development 1.16
30 Estrogen receptor antagonism leading to reproductive dysfunction Dan Villeneuve BY-SA 112: Antagonism, Estrogen receptor 360: Decrease, Population growth rate Under Review 1.12
29 Estrogen receptor agonism leading to reproductive dysfunction Undefined BY-SA 111: Agonism, Estrogen receptor
28 Cyclooxygenase inhibition leading reproductive failure Dan Villeneuve BY-SA 79: Inhibition, Cyclooxygenase activity 253: N/A, Reproductive failure
27 Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) Mathieu Vinken BY-SA 41: Inhibition, Bile Salt Export Pump (ABCB11) 357: Cholestasis, Pathology Under Development 1.19
26 Calcium-mediated neuronal ROS production and energy imbalance Lyle Burgoon Open for adoption 51: Inhibition, Ca++ ATPase 1392: Increase, Oxidative Stress
25 Aromatase inhibition leading to reproductive dysfunction Dan Villeneuve BY-SA 36: Inhibition, Aromatase 360: Decrease, Population growth rate WPHA/WNT Endorsed 1.12
23 Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) Dan Villeneuve BY-SA 25: Agonism, Androgen receptor 360: Decrease, Population growth rate WPHA/WNT Endorsed 1.12
21 Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 Markus Hecker BY-SA 18: Activation, AhR None WPHA/WNT Endorsed 1.27
19 Androgen receptor antagonism leading to adverse effects in the male foetus (mammals) Mukesh Patel Open for adoption 26: Antagonism, Androgen receptor 337: N/A, Impairment of reproductive capacity
18 PPARα activation in utero leading to impaired fertility in males Elise Grignard BY-SA 227: Activation, PPARα Under Review 1.21