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All Key Events

Showing 1151 to 1175 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1611	Reduction, androstenedione Short Name Reduction, androstenedione	0	Tissue	Apr 10, 2019	Apr 9, 2025	288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)
1613	Decrease, dihydrotestosterone (DHT) levels Short Name Decrease, DHT level	1	Tissue	Apr 10, 2019	Aug 13, 2025	6 AOPs 288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) 289: Inhibition of 5α-reductase leading to impaired fecundity in female fish 305: 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring 527: Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Hypospadias, increased 571: 5α-reductase inhibition leading to hypospadias in male (mammalian) offspring 576: 5α-reductase inhibition leading to increased nipple retention (NR) in male (rodent) offspring
1614	Decrease, androgen receptor activation Short Name Decrease, AR activation	1	Tissue	Apr 10, 2019	Feb 4, 2026	13 AOPs 288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) 305: 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring 306: Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring 344: Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring 372: Androgen receptor antagonism leading to testicular cancer 477: Androgen receptor (AR) antagonism leading to hypospadias in male (mammalian) offspring 345: Androgen receptor (AR) antagonism leading to decreased fertility in females 111: Decrease in androgen receptor activity leading to Leydig cell tumors (in rat) 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring 571: 5α-reductase inhibition leading to hypospadias in male (mammalian) offspring 575: Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring 576: 5α-reductase inhibition leading to increased nipple retention (NR) in male (rodent) offspring
1615	Impaired inguinoscrotal testicular descent phase Short Name Impaired inguinoscrotal phase	1	Organ	Apr 10, 2019	Dec 3, 2024	2 AOPs 288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) 528: Decreased Insulin-like peptide 3 (INSL3) leads to Malformation, cryptorchidism - maldescended testis
1616	Malformation, cryptorchidism - maldescended testis Short Name Malformation, cryptorchidism	1	Organ	Apr 10, 2019	Jul 18, 2024	4 AOPs 288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) 372: Androgen receptor antagonism leading to testicular cancer 476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity 528: Decreased Insulin-like peptide 3 (INSL3) leads to Malformation, cryptorchidism - maldescended testis
1617	Inhibition, 5α-reductase Short Name Inhibition, 5α-reductase	0	Molecular	Apr 18, 2019	Feb 4, 2026	5 AOPs 289: Inhibition of 5α-reductase leading to impaired fecundity in female fish 305: 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring 120: Inhibition of 5α-reductase leading to Leydig cell tumors (in rat) 571: 5α-reductase inhibition leading to hypospadias in male (mammalian) offspring 576: 5α-reductase inhibition leading to increased nipple retention (NR) in male (rodent) offspring
1618	Reduction, egg production and spawning Short Name Reduction, egg production and spawning	0	Individual	Apr 18, 2019	Apr 18, 2019	None
1619	Increase, DNA methyltransferase inhibition Short Name Increase, DNMT inhibition	0	Molecular	Apr 22, 2019	Apr 22, 2019	7 AOPs 336: DNA methyltransferase inhibition leading to population decline (1) 337: DNA methyltransferase inhibition leading to population decline (2) 338: DNA methyltransferase inhibition leading to population decline (3) 339: DNA methyltransferase inhibition leading to population decline (4) 340: DNA methyltransferase inhibition leading to transgenerational effects (1) 341: DNA methyltransferase inhibition leading to transgenerational effects (2) 474: Succinate dehydrogenase inactivation leads to cancer by promoting EMT
1620	Increase, DNA hypomethylation Short Name Increase, DNA hypomethylation	0	Molecular	Apr 22, 2019	Apr 22, 2019	None
1621	Increase, Gene expression Short Name Increase, Gene expression	0	Molecular	Apr 22, 2019	Apr 22, 2019	None
1622	Decrease, Transgenerational DNA methylation Short Name	0	Molecular	Apr 22, 2019	Apr 22, 2019	None
1623	Occurrence, Focal Seizure Short Name Occurrence, Focal Seizure	1	Tissue	Apr 22, 2019	May 20, 2020	281: Acetylcholinesterase Inhibition Leading to Neurodegeneration
1624	Tyrosinase inhibition leads to L-Dopaquinone reduction Short Name tyrosinase, L-Dopaquinone reduction	0	Molecular	May 3, 2019	May 3, 2019	None
1625	Reduction of L-Dopaquinone leads to melanin reduction Short Name melanin	0	Cellular	May 3, 2019	May 3, 2019	None
1626	reduction in melanin lead to decrease of pigmentation Short Name melanin, pigmentation	0	Tissue	May 3, 2019	May 3, 2019	None
1627	Inhibition of tyrosinase Short Name tyrosinase	0	Molecular	May 3, 2019	May 3, 2019	292: Inhibition of tyrosinase leads to decreased population in fish
1628	Reduction of L-Dopaquinone Short Name Reduction of L-Dopaquinone	0	Cellular	May 3, 2019	May 3, 2019	292: Inhibition of tyrosinase leads to decreased population in fish
1629	Reduction in melanin level Short Name Reduction in melanin level	0	Cellular	May 3, 2019	May 3, 2019	292: Inhibition of tyrosinase leads to decreased population in fish
1630	Reduction of melanosome level Short Name Reduction of melanosome level	0	Tissue	May 3, 2019	May 3, 2019	292: Inhibition of tyrosinase leads to decreased population in fish
1631	Reduction fo Pigmentation pattern Short Name Reduction fo Pigmentation pattern	0	Individual	May 3, 2019	May 3, 2019	292: Inhibition of tyrosinase leads to decreased population in fish
1632	Increase in reactive oxygen and nitrogen species (RONS) Short Name Increase in RONS	0	Molecular	May 3, 2019	May 8, 2019	5 AOPs 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 432: Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability 473: Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
1633	Increase in inflammation Short Name Increase in inflammation	0	Tissue	May 3, 2019	May 3, 2019	3 AOPs 362: Immune mediated hepatitis 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways 493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
1634	Increase, Oxidative DNA damage Short Name Increase, Oxidative DNA damage	1	Molecular	May 19, 2019	Oct 8, 2024	6 AOPs 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis 478: Deposition of energy leading to occurrence of cataracts 330: Excessive reactive oxygen species production leading to mortality (4) 602: Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage
1635	Increase, DNA strand breaks Short Name Increase, DNA strand breaks	1	Molecular	May 19, 2019	Dec 17, 2024	10 AOPs 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 272: Deposition of energy leading to lung cancer 322: Alkylation of DNA leading to reduced sperm count 216: Deposition of energy leading to population decline via DNA strand breaks and follicular atresia 238: Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis 478: Deposition of energy leading to occurrence of cataracts 483: Deposition of Energy Leading to Learning and Memory Impairment 470: Deposition of energy leads to abnormal vascular remodeling 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis 602: Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage
1636	Increase, Chromosomal aberrations Short Name Increase, Chromosomal aberrations	1	Cellular	May 19, 2019	Mar 8, 2024	3 AOPs 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 272: Deposition of energy leading to lung cancer 478: Deposition of energy leading to occurrence of cataracts