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All Key Events

Showing 1726 to 1750 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

450	Decrease, Very low-density lipoprotein export capacity Short Name Decrease, VLDL export capacity	1	Cellular	Nov 29, 2016	Feb 12, 2026	57: AhR activation leading to hepatic steatosis
447	Reduction, Cholesterol transport in mitochondria Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 51: PPARα activation leading to impaired fertility in adult male rodents 18: PPARα activation in utero leading to impaired fertility in males
446	Reduction, fetal/adult testosterone Short Name Reduction of testosterone	1	Tissue	Nov 29, 2016	May 17, 2023	476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity
445	Respiratory distress/arrest Short Name Respiratory distress/arrest	1	Organ	Nov 29, 2016	Dec 20, 2019	2 AOPs 16: Acetylcholinesterase inhibition leading to acute mortality 94: Sodium channel inhibition leading to congenital malformations
444	Increased, Atrioventricular block and bradycardia Short Name	2	Organ	Nov 29, 2016	Sep 16, 2017	94: Sodium channel inhibition leading to congenital malformations
442	Decreased, Population trajectory Short Name Decreased, Population trajectory	1	Population	Nov 29, 2016	Apr 18, 2017	3 AOPs 435: Deposition of ionising energy leads to population decline via pollen abnormal 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish
429	Cellular Proliferation and Clonal Expansion of Mutant Cells (Pre-neoplastic Foci), Alteration of cellular growth homeostasis Short Name	0		Nov 29, 2016	Nov 29, 2016	None
428	Delay, Developmental GABA shift Short Name Delay, Developmental GABA shift	0	Cellular	Nov 29, 2016	Nov 29, 2016	None
427	Down Regulation, K-Cl co-transporter 2 (KCC2) Short Name	0	Cellular	Nov 29, 2016	Nov 29, 2016	None
425	Decrease of Thyroidal iodide Short Name Thyroidal Iodide, Decreased	1	Cellular	Nov 29, 2016	Apr 4, 2019	4 AOPs 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 134: Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 176: Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis 188: Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis
424	Inhibition, Na+/I- symporter (NIS) Short Name Inhibition, Na+/I- symporter (NIS)	1	Molecular	Nov 29, 2016	Apr 27, 2026	5 AOPs 65: XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 134: Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 176: Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis 110: Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse)
423	Increased, Clonal Expansion / Cell Proliferation to Form Pre-Neoplastic Altered Hepatic Foci Short Name	0		Nov 29, 2016	Nov 29, 2016	None
422	Increased, nephropathy Short Name Increased, nephropathy	1	Individual	Nov 29, 2016	Dec 3, 2016	53: ER agonism leading to reduced survival due to renal failure
421	Increased, glomerular rupture and renal hemorrhaging Short Name	2	Organ	Nov 29, 2016	Sep 16, 2017	53: ER agonism leading to reduced survival due to renal failure
419	Increased, renal vitellogenin deposition Short Name	1	Organ	Nov 29, 2016	Sep 16, 2017	53: ER agonism leading to reduced survival due to renal failure
418	Increased, Vitellogenin synthesis Short Name Increased, Vitellogenin synthesis	1	Cellular	Nov 29, 2016	Sep 16, 2017	53: ER agonism leading to reduced survival due to renal failure
417	skewed, sex ratio Short Name skewed, sex ratio	1	Population	Nov 29, 2016	Dec 3, 2016	52: ER agonism leading to skewed sex ratios due to altered sexual differentiation in males
416	Increase proliferation, Leydig cell Short Name Increase proliferation, Leydig cell	1	Cellular	Nov 29, 2016	Sep 16, 2017	51: PPARα activation leading to impaired fertility in adult male rodents
415	Hyperplasia, Leydig cell Short Name Hyperplasia, Leydig cell	1	Cellular	Nov 29, 2016	Sep 27, 2017	51: PPARα activation leading to impaired fertility in adult male rodents
414	Increase, Luteinizing hormone (LH) Short Name Increase, Luteinizing hormone (LH)	1	Cellular	Nov 29, 2016	Sep 16, 2017	51: PPARα activation leading to impaired fertility in adult male rodents
413	Reduction, Testosterone synthesis in Leydig cells Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	3 AOPs 51: PPARα activation leading to impaired fertility in adult male rodents 18: PPARα activation in utero leading to impaired fertility in males 64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility
409	Metabolism of AFB1, Production of Reactive Electrophiles Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	46: AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
408	reduction in ovarian granulosa cells, Aromatase (Cyp19a1) Short Name	2	Cellular	Nov 29, 2016	May 28, 2021	7: Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female
406	decreased, Fertility Short Name decreased, Fertility	2	Individual	Nov 29, 2016	Dec 17, 2024	13 AOPs 7: Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female 51: PPARα activation leading to impaired fertility in adult male rodents 18: PPARα activation in utero leading to impaired fertility in males 64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility 348: Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory 349: Inhibition of 11β-hydroxylase leading to decresed population trajectory 396: Deposition of ionizing energy leads to population decline via impaired meiosis 398: Decreased ALDH1A (RALDH) activity leading to decreased fertility via disrupted meiotic initiation of fetal oogonia 492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress 345: Androgen receptor (AR) antagonism leading to decreased fertility in females 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis 400: Inhibition of CYP26B1 activity in fetal testis leading to reduced fertility 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle
405	disrupted, ovarian cycle Short Name disrupted, ovarian cycle	1	Individual	Nov 29, 2016	Dec 17, 2024	3 AOPs 7: Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female 398: Decreased ALDH1A (RALDH) activity leading to decreased fertility via disrupted meiotic initiation of fetal oogonia 345: Androgen receptor (AR) antagonism leading to decreased fertility in females