Key Event Relationships (KERs)

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Showing 1901 to 1925 of 3081 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
2323 1852: Increased Ang II type 1 receptor (AT1R) 1115: Increase, ROS Apr 10, 2021 Apr 10, 2021
2066 1752: Increased AngII 1743: Increase plasma Ang II Mar 17, 2020 Mar 17, 2020 None
2298 1752: Increased AngII 1849: Impaired gustatory nerve Mar 28, 2021 Mar 28, 2021 None
2300 1752: Increased AngII 1496: Increased proinflammatory mediators Mar 28, 2021 Mar 28, 2021 None
2317 1752: Increased AngII 1856: Sodium inhibition, Sweet enhancement Apr 10, 2021 Apr 10, 2021
2327 1752: Increased AngII 1852: Increased Ang II type 1 receptor (AT1R) Apr 10, 2021 Apr 10, 2021
2593 1752: Increased AngII 1851: Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R) Mar 3, 2022 Mar 3, 2022
1647 496: Decreased Leydig Cells 413: Reduction, Testosterone synthesis in Leydig cells Aug 11, 2017 Aug 11, 2017
2030 1722: Increased blood CCK level 1723: Increased acinar cell exocrine secretion Jan 8, 2020 Jan 8, 2020
1955 1663: brain Homocysteine level increases 1664: Neuronal dysfunctions induction Jun 14, 2019 Jun 14, 2019 None
1579 1433: Increased CGRP 1223: Increased Airway Hyper-responsiveness,Cough, Dyspnea Jun 23, 2017 Jun 23, 2017 None
1580 1433: Increased CGRP 1343: Increase, hypertension Jun 23, 2017 Jun 23, 2017 None
1586 1433: Increased CGRP 1225: Leukocyte infiltration Jun 23, 2017 Jun 23, 2017 None
1587 1433: Increased CGRP 1226: Respiratory irritability Jun 27, 2017 Jun 27, 2017
51 39: Increased Cholinergic Signaling 360: Decrease, Population growth rate Nov 29, 2016 Dec 3, 2016 None
434 39: Increased Cholinergic Signaling 351: Increased Mortality Nov 29, 2016 Dec 3, 2016 None
457 39: Increased Cholinergic Signaling 445: Respiratory distress/arrest Nov 29, 2016 Dec 20, 2019
2005 39: Increased Cholinergic Signaling 1703: Cardiovascular dysregulation Nov 25, 2019 Dec 20, 2019
2011 39: Increased Cholinergic Signaling 1705: Impaired coordination and movement Dec 20, 2019 Dec 20, 2019
2410 39: Increased Cholinergic Signaling 386: Neuronal network function, Decreased Jun 24, 2021 Sep 1, 2021
2412 39: Increased Cholinergic Signaling 402: Cognitive function, decreased Jun 24, 2021 Sep 1, 2021
3405 2280: Prolonged atrioventricular (AV) 1106: Occurrence, cardiac arrhythmia Nov 20, 2024 Nov 20, 2024
2031 1723: Increased acinar cell exocrine secretion 1724: Acinar cell proliferation Jan 8, 2020 Jan 8, 2020
2876 2125: Increased fat mass 1497: Recruitment of inflammatory cells Apr 5, 2023 Apr 5, 2023
2901 2125: Increased fat mass 2132: Increased cytokine expression May 4, 2023 May 4, 2023