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Showing 26 to 50 of 574 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
33 Kidney toxicity induced by activation of 5HT2C Kevin Crofton Open for adoption 9: Activation, 5HT2c 759: Increased, Kidney Failure
34 LXR activation leading to hepatic steatosis Undefined BY-SA 345: N/A, Liver Steatosis
35 Narcosis leading to respiratory failure Dries Knapen BY-SA 46: Accumulation, Biological membranes None Under Development 1.2
36 Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis Michelle Angrish BY-SA 459: Increase, Liver steatosis
37 PPARα activation leading to hepatocellular adenomas and carcinomas in rodents Chris Corton BY-SA 227: Activation, PPARα 719: Increase, hepatocellular adenomas and carcinomas Under Development 1.17
38 Protein Alkylation leading to Liver Fibrosis Brigitte Landesmann BY-SA 244: Alkylation, Protein 344: Increase, Liver fibrosis WPHA/WNT Endorsed 1.14
39 Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response Jessica Ponder BY-SA 396: Covalent Binding, Protein 313: Increase, Allergic Respiratory Hypersensitivity Response Under Development 1.20
40 Covalent Protein binding leading to Skin Sensitisation Undefined BY-SA 396: Covalent Binding, Protein 827: sensitisation, skin WPHA/WNT Endorsed 1.1
41 Sustained AhR Activation leading to Rodent Liver Tumours Undefined BY-SA 165: Activation, Long term AHR receptor driven direct and indirect gene expression changes 856: Formation, Hepatocellular and Bile duct tumors Under Review 1.7
42 Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Kevin Crofton BY-SA 279: Thyroperoxidase, Inhibition 402: Cognitive function, decreased WPHA/WNT Endorsed 1.10
43 Disruption of VEGFR Signaling Leading to Developmental Defects Undefined BY-SA 305: Inhibition, VegfR2 1001: Increased, Developmental Defects WPHA/WNT Endorsed 1.6
46 AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC) Ted Simon BY-SA 373: Formation, Pro-mutagenic DNA Adducts 378: Tumorigenesis, Hepatocellular carcinoma Under Review 1.8
48 Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. Anna Price BY-SA 875: Binding of agonist, Ionotropic glutamate receptors 341: Impairment, Learning and memory WPHA/WNT Endorsed 1.23
51 PPARα activation leading to impaired fertility in adult male rodents Elise Grignard BY-SA 227: Activation, PPARα 406: decreased, Fertility Under Development 1.21
52 ER agonism leading to skewed sex ratios due to altered sexual differentiation in males Undefined BY-SA 111: Agonism, Estrogen receptor 417: skewed, sex ratio
53 ER agonism leading to reduced survival due to renal failure Undefined BY-SA 111: Agonism, Estrogen receptor None
54 Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment Anna Price BY-SA 424: Inhibition, Na+/I- symporter (NIS) 341: Impairment, Learning and memory WPHA/WNT Endorsed 1.28
57 AhR activation leading to hepatic steatosis Michelle Angrish BY-SA 18: Activation, AhR 459: Increase, Liver steatosis
58 NR1I3 (CAR) suppression leading to hepatic steatosis Michelle Angrish BY-SA 459: Increase, Liver steatosis
59 HNF4alpha suppression leading to hepatic steatosis Michelle Angrish BY-SA 461: Suppression, HNF4alpha None
60 NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis Michelle Angrish BY-SA 245: Activation, PXR/SXR 459: Increase, Liver steatosis
61 NFE2L2/FXR activation leading to hepatic steatosis Michelle Angrish BY-SA 459: Increase, Liver steatosis
62 AKT2 activation leading to hepatic steatosis Michelle Angrish BY-SA 486: systemic inflammation leading to hepatic steatosis 459: Increase, Liver steatosis
63 Cyclooxygenase inhibition leading to reproductive dysfunction Dalma Martinovic-Weigelt BY-SA 79: Inhibition, Cyclooxygenase activity
64 Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility Undefined BY-SA 494: Glucocorticoid Receptor Agonist, Activation 406: decreased, Fertility