AOPs

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Showing 1 to 25 of 30 Fulltext Results
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ID Title Point of Contact License MIE AO OECD Status OECD Project
3 Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits Andrea Terron BY-SA 888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) 896: Parkinsonian motor deficits WPHA/WNT Endorsed 1.33
16 Acetylcholinesterase inhibition leading to acute mortality Dan Villeneuve BY-SA 12: Acetylcholinesterase (AchE) Inhibition Under Development 1.3
17 Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory Marie-Gabrielle Zurich BY-SA 1487: Binding, Thiol/seleno-proteins involved in protection against oxidative stress 341: Impairment, Learning and memory WPHA/WNT Endorsed 1.13
21 Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 Markus Hecker BY-SA 18: Activation, AhR None WPHA/WNT Endorsed 1.27
39 Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response Jessica Ponder BY-SA 396: Covalent Binding, Protein 313: Increase, Allergic Respiratory Hypersensitivity Response Under Development 1.20
43 Disruption of VEGFR Signaling Leading to Developmental Defects Undefined BY-SA 305: Inhibition, VegfR2 1001: Increased, Developmental Defects WPHA/WNT Endorsed 1.6
131 Aryl hydrocarbon receptor activation leading to uroporphyria Amani Farhat BY-SA 18: Activation, AhR 369: Uroporphyria WPHA/WNT Endorsed 1.7
149 Peptide Oxidation Leading to Hypertension Frazer Lowe BY-SA 209: Peptide Oxidation 952: Hypertension Under Development 1.50
150 Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF Amani Farhat BY-SA 18: Activation, AhR 947: Increase, Early Life Stage Mortality WPHA/WNT Endorsed 1.7
154 Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response Takumi Ohishi BY-SA 980: Inhibition, Calcineurin Activity 984: Impairment, T-cell dependent antibody response WPHA/WNT Endorsed 1.38
205 AOP from chemical insult to cell death Mathieu Vinken BY-SA
208 Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure Jinhee Choi All rights reserved None 1277: Reproductive failure
220 Cyp2E1 Activation Leading to Liver Cancer Francina Webster BY-SA 1391: Activation of Cyp2E1 1395: Liver Cancer WPHA/WNT Endorsed 1.24
277 Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response Takao Ashikaga BY-SA 1700: Impaired IL-1R1 signaling in T cell 984: Impairment, T-cell dependent antibody response WPHA/WNT Endorsed 1.48
293 Increased DNA damage leading to increased risk of breast cancer Jessica Helm BY-SA 1194: Increase, DNA damage Under Development 1.80
294 Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer Jessica Helm BY-SA 1632: Increase in reactive oxygen and nitrogen species (RONS) Under Development 1.80
312 Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement​ Kristie Sullivan BY-SA 12: Acetylcholinesterase (AchE) Inhibition
348 Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory Young Jun Kim BY-SA 1799: Inhibition of 11β-HSD 360: Decrease, Population growth rate Under Development 1.93
374 Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis Anna Price All rights reserved 1739: Binding to ACE2 1841: Encephalitis Under Development 1.96
379 Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation Shihori Tanabe All rights reserved 1739: Binding to ACE2 1846: Thrombosis and Disseminated Intravascular Coagulation Under Development 1.96
396 Deposition of ionizing energy leads to population decline via impaired meiosis Erica Maremonti All rights reserved 1550: Deposition of Ionizing Energy
397 Bulky DNA adducts leading to mutations Carole Yauk BY-SA 1879: Bulky DNA adducts, increase 185: Increase, Mutations Under Development 1.11
439 Activation of the AhR leading to metastatic breast cancer Louise Benoit BY-SA 18: Activation, AhR 1982: metastatic breast cancer Under Review 1.105
468 Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death) Laure-Alix Clerbaux BY-SA 1739: Binding to ACE2 1868: Hyperinflammation
483 Deposition of Energy Leading to Learning and Memory Impairment Vinita Chauhan BY-SA 1686: Deposition of Energy 341: Impairment, Learning and memory WPHA/WNT Endorsed 1.89