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ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

244	Alkylation, Protein Short Name Alkylation, Protein	1	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 38: Protein Alkylation leading to Liver Fibrosis 258: Renal protein alkylation leading to kidney toxicity
264	Activation, SREBP-1c Short Name Activation, SREBP-1c	1	Molecular	Nov 29, 2016	Sep 16, 2017	34: LXR activation leading to hepatic steatosis
312	N/A, Allergic contact dermatitis on challenge Short Name	0	Individual	Nov 29, 2016	Nov 29, 2016	None
369	Uroporphyria Short Name Uroporphyria	1	Individual	Nov 29, 2016	May 7, 2018	131: Aryl hydrocarbon receptor activation leading to uroporphyria
397	Response, Keratinocytes Short Name Response, Keratinocytes	0	Cellular	Nov 29, 2016	Nov 29, 2016	None
709	Increase, Cytotoxicity (renal tubular cell) Short Name	1	Cellular	Nov 29, 2016	Mar 3, 2022	5 AOPs 105: Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) 256: Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity 257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity 258: Renal protein alkylation leading to kidney toxicity 437: Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity
826	Activation, Keratinocytes Short Name Activation, Keratinocytes	2	Cellular	Nov 29, 2016	Sep 16, 2017	40: Covalent Protein binding leading to Skin Sensitisation
827	sensitisation, skin Short Name sensitisation, skin	0	Organ	Nov 29, 2016	Nov 29, 2016	40: Covalent Protein binding leading to Skin Sensitisation
845	Inhibition, UROD Short Name Inhibition, UROD	1	Molecular	Nov 29, 2016	May 30, 2018	131: Aryl hydrocarbon receptor activation leading to uroporphyria
850	Induction, CYP1A2/CYP1A5 Short Name Induction, CYP1A2/CYP1A5	2	Molecular	Nov 29, 2016	May 30, 2018	2 AOPs 131: Aryl hydrocarbon receptor activation leading to uroporphyria 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
901	Infiltration, Inflammatory cells Short Name Infiltration, Inflammatory cells	1	Tissue	Nov 29, 2016	Sep 16, 2017	462: Activation of reactive oxygen species leading the atherosclerosis
902	Inflammation, Liver Short Name Inflammation, Liver	1	Organ	Nov 29, 2016	Sep 16, 2017	2 AOPs 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 615: Suppression of Keap1 cysteine oxidation leading to liver inflammation
945	reduced dimerization, ARNT/HIF1-alpha Short Name reduced dimerization, ARNT/HIF1-alpha	2	Molecular	Nov 29, 2016	Mar 23, 2018	2 AOPs 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF 151: AhR activation leading to preeclampsia
957	Binding, Transthyretin in serum Short Name Binding, Transthyretin in serum	1	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity 366: Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis
1172	Increased activation, Nuclear factor kappa B (NF-kB) Short Name	1	Cellular	Nov 29, 2016	Aug 27, 2023	5 AOPs 382: Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 319: Binding to ACE2 leading to lung fibrosis 443: DNA damage and mutations leading to Metastatic Breast Cancer 622: Calcineurin inhibitor induced nephrotoxicity leading to kidney failure
1572	Impaired IL-1 signaling Short Name Impaired IL-1 signaling	0	Molecular	Dec 24, 2018	Jun 24, 2019	None
1573	Suppressed MyD88 Short Name Suppressed MyD88	0	Cellular	Jan 6, 2019	Mar 17, 2019	None
1575	Activation, Caspase 8 pathway Short Name Activation, Caspase 8 pathway	0	Molecular	Jan 7, 2019	Mar 7, 2019	278: IKK complex inhibition leading to liver injury
1580	Binding of microtubule stabilizing agents (MSA) to microtubules Short Name Binding of MSAs to microtubules	0	Molecular	Jan 29, 2019	Jan 29, 2019	279: Microtubule interacting drugs lead to peripheral neuropathy
1634	Increase, Oxidative DNA damage Short Name Increase, Oxidative DNA damage	1	Molecular	May 19, 2019	Oct 8, 2024	6 AOPs 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis 478: Deposition of energy leading to occurrence of cataracts 330: Excessive reactive oxygen species production leading to mortality (4) 602: Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage
1668	Frustrated phagocytosis Short Name Frustrated phagocytosis	1	Cellular	Jul 3, 2019	Sep 16, 2022	2 AOPs 303: Frustrated phagocytosis-induced lung cancer 409: Frustrated phagocytosis leads to malignant mesothelioma
1706	Stimulation, TLR7/8 Short Name Stimulation of TLR7/8	0	Molecular	Dec 27, 2019	Nov 21, 2020	313: Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease
1722	Increased blood CCK level Short Name Increased blood CCK level	0	Organ	Jan 8, 2020	Jan 8, 2020	316: Trypsin inhibition leading to pancreatic acinar cell tumors
1771	Decrease, Adenosine triphosphate pool Short Name Decrease, ATP pool	1	Cellular	Apr 30, 2020	Jun 14, 2021	21 AOPs 328: Excessive reactive oxygen species production leading to mortality (2) 329: Excessive reactive oxygen species production leading to mortality (3) 264: Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death 263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2) 286: Mitochondrial complex III antagonism leading to growth inhibition (1) 287: Mitochondrial complex III antagonism leading to growth inhibition (2) 266: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity 333: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and reduced cell proliferation 324: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and cell death 325: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and reduced cell growth 326: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and reduced cell proliferation 331: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 332: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and reduced cell growth 596: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death 598: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and reduced cell proliferation 599: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death 600: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth 601: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation 612: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced adenosine triphosphate
1869	Diminished protective oxidative stress response Short Name Diminished Protective Response to ROS	3	Cellular	Apr 20, 2021	Oct 30, 2023	5 AOPs 379: Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation 406: SARS-CoV-2 infection leading to hyperinflammation 407: SARS-CoV-2 infection leading to pyroptosis 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 488: Increased reactive oxygen species production leading to decreased cognitive function

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